IL-2 mediates NK cell proliferation but not hyperactivity.

abstract：:The Cluster of differentiation 226(CD226)/T cell immunoglobulin and immune receptor tyrosine-based inhibitory motif domain (TIGIT) axis plays an important role in the balance of the immune response. A previous study showed that CD226 is involved in CD4+ T cell differentiation and that blocking CD226 may attenuate expe...

journal_title：Immunologic research

authors： Wang N,Liang S,Jin J,Fang L,Ma Q,Wang X,Song Y,Chen L

更新日期：2019-12-01 00:00:00

abstract：:The tick-borne encephalitis (TBE) serocomplex of viruses, genus Flavivirus, includes a number of important human pathogens that cause serious neurological illnesses and hemorrhagic fevers. These viruses pose a significant public health problem due to high rates of morbidity and mortality, their emergence to new geogra...

journal_title：Immunologic research

authors： Robertson SJ,Mitzel DN,Taylor RT,Best SM,Bloom ME

更新日期：2009-01-01 00:00:00

abstract：:Studies on the biologic and molecular genetic underpinnings of multiple myeloma (MM) have identified the pleiotropic, pro-inflammatory cytokine, interleukin-6 (IL-6), as a factor crucial to the growth, proliferation and survival of myeloma cells. IL-6 is also a potent stimulator of osteoclastogenesis and a sculptor of...

journal_title：Immunologic research

authors： Rosean TR,Tompkins VS,Tricot G,Holman CJ,Olivier AK,Zhan F,Janz S

更新日期：2014-08-01 00:00:00

abstract：:Diabetes is a chronic autoimmune disease that affects 4-5% of the world's population. If the present trends continue, diabetes would soon become a major/leading health problem worldwide. Hence there is an urgent need to develop novel approaches for the treatment of diabetes. While transplantation of the pancreas or th...

journal_title：Immunologic research

authors： Chan KM,Raikwar SP,Zavazava N

更新日期：2007-01-01 00:00:00

abstract：:The "X chromosome-nucleolus nexus" hypothesis provides a comprehensive explanation of how autoantibodies can develop following cellular stress. The hypothesis connects autoimmune diseases with the impact of environmental factors, such as viruses, through epigenetic disruption. The inactive X chromosome, a major epigen...

journal_title：Immunologic research

authors： Brooks WH

更新日期：2018-12-01 00:00:00

abstract：:Heat shock proteins (HSPs) are evolutionarily highly conserved polypeptides synthesized by many cells to preserve cellular functions under a variety of stressful conditions including infections. We have investigated the involvement of 65-kDa HSP (HSP65) in host protection against an intracellular protozoan parasite, T...

journal_title：Immunologic research

authors： Himeno K,Hisaeda H

更新日期：1996-01-01 00:00:00

abstract：:Naive CD4 T cell activation is a complex process involving many steps. T cell receptor (TCR) signals, provided by interaction with peptide/MHC on antigen-presenting cells (APC), control many events associated with activation. The extent of TCR signaling and the magnitude of the T cell response is in turn controlled by...

journal_title：Immunologic research

authors： Dubey C,Croft M

更新日期：1996-01-01 00:00:00

abstract：:Class II MHC molecules present processed peptides from exogenous antigens to CD4+ helper T lymphocytes. In so doing, they are central to immunity, driving both the humoral and cell mediated arms of the immune response. Class II MHC molecules, and the genes encoding them, are expressed primarily in cells of the immune ...

journal_title：Immunologic research

authors： Radosevich M,Ono SJ

更新日期：2003-01-01 00:00:00

abstract：:There is increasing documentation of significant survival benefits achieved in cancer patients treated with hyperthermia in combination with radiation and/or chemotherapy. Most evidence collected regarding the mechanisms by which hyperthermia positively influences tumor control has centered on in vitro data showing th...

journal_title：Immunologic research

authors： Peer AJ,Grimm MJ,Zynda ER,Repasky EA

更新日期：2010-03-01 00:00:00

abstract：:Assembly of the class I MHC molecule is inextricably linked to the antigen presentation function of the class I molecule. Association of the class I MHC molecule with beta 2-microglobulin (beta 2m) is a prerequisite for association with the heterodimeric protein TAP, and once peptide is acquired, the class I molecule ...

journal_title：Immunologic research

authors： Solheim JC,Cook JR,Hansen TH

更新日期：1995-01-01 00:00:00

abstract：:Pathologies attributable to fungal infections represent a growing concern in both developed and developing countries. Initially discovered as opportunistic pathogens of immunocompromised hosts, fungi such as Candida albicans are now being placed at the centre of a more complex and dynamic picture in which the outcome ...

journal_title：Immunologic research

authors： Cottier F,Pavelka N

更新日期：2012-09-01 00:00:00

abstract：:The erbB family of receptor tyrosine kinases are growth factor receptors that are overexpressed or mutated in a large variety of human cancers. Studies of erbB-mediated signal transduction will lead to an understanding of the role played by this family of receptors in normal and transformed cells. In this article, we ...

journal_title：Immunologic research

authors： O'Rourke DM,Greene MI

更新日期：1998-01-01 00:00:00

abstract：:Neutrophils are key effector cells of the innate immune system and are involved in the host defense against invading pathogens such as viruses. Recently, it was reported that HIV-1-neutrophil interaction triggers neutrophil activation and promotes expression of Toll-like receptors (TLRs). Here, we assessed the role of...

journal_title：Immunologic research

authors： Giraldo DM,Hernandez JC,Urcuqui-Inchima S

更新日期：2016-12-01 00:00:00

abstract：:Rituximab is a chimeric monoclonal anti-CD20 antibody and was the first monoclonal antibody (mAb) therapy approved by FDA (Food and Drug Administration) for the treatment of B-cell lymphoma. It has revolutionized the treatment of patients with CD20-positive non-Hodgkin's lymphoma and CLL. Rituximab is currently being ...

journal_title：Immunologic research

authors： Riaz W,Hernandez-Ilizaliturri FJ,Czuczman MS

更新日期：2010-03-01 00:00:00

abstract：:Limited protective effects of commercially available vaccines necessitate the development of novel pneumococcal vaccines. We recently reported a pneumococcal systemic vaccine containing two proteins, Pneumococcal surface protein A (PspA of family 1 and 2) and a bacterium-like particle-based pneumococcal mucosal vaccin...

journal_title：Immunologic research

authors： Zhang Y,Guo X,Guo M,Chen X,Li B,Yu J,Gu T,Kong W,Wu Y

更新日期：2019-10-01 00:00:00

abstract：:The aim of the present study was to investigate the association between the presence of albuminuria and cytokines profile with biomarkers of endothelial damage and oxidative stress in patients with type 1 diabetes mellitus (DM1). The sample was composed by 35 healthy individuals, 63 DM1 patients with normoalbuminuria ...

journal_title：Immunologic research

authors： Pestana RM,Domingueti CP,Duarte RC,Fóscolo RB,Reis JS,Rodrigues AM,Martins LB,Sousa LP,Lage DP,Ferreira CN,Ferreira AV,Fernandes AP,Gomes KB

更新日期：2016-08-01 00:00:00

abstract：:Contact hypersensitivity (CHS) is a T cell-mediated immune response to cutaneous sensitization and subsequent challenge with haptens such as dinitrofluorobenzene and oxazolone. Many aspects concerning the development and regulation of CHS remain unknown. Using CHS as a model of T cell-mediated immune responses to anti...

journal_title：Immunologic research

authors： Gorbachev AV,Fairchild RL

更新日期：2001-01-01 00:00:00

abstract：:Bronchiolitis obliterans organizing pneumonia (BOOP) is defined by buds of granulation tissue within lung distal airspaces. The diagnosis requires the histopathologic evidence of organizing pneumonia along with a suggestive clinical and radiographic pattern. This disorder is characterized by a good response to cortico...

journal_title：Immunologic research

authors： Rojas CM,Borella E,Palma L,Ragozzino S,De Ramón E,Gomez-Huelgas R,Punzi L,Doria A

更新日期：2015-02-01 00:00:00

abstract：:Type I diabetes (T1D) is a chronic autoimmune disease caused by pancreatic β-cell destruction induced by autoantibodies and autoreactive T cells. After significant reduction of the β-cell mass, diabetes sets in and can cause significant complications. It is estimated that more than 3 million Americans have T1D, and it...

journal_title：Immunologic research

authors： Manzar GS,Kim EM,Rotti P,Zavazava N

更新日期：2014-08-01 00:00:00

abstract：:Tumor necrosis factor (TNF) inhibitors have been found to exhibit certain efficacy in treating refractory Takayasu arteritis (TA) in clinic despite severe adverse effects. The aim of this study is to investigate a natural anti-TNF compound, curcumin, its function, and its potential as treatment against TA. In total, 2...

journal_title：Immunologic research

authors： Shao N,Jia H,Li Y,Li J

更新日期：2017-08-01 00:00:00

abstract：:Immunological memory is a hallmark of adaptive immunity, a defense mechanism endowed to vertebrates during evolution. However, an autoimmune pathogenic role of memory lymphocytes is also emerging with accumulating evidence, despite reasonable skepticism on their existence in a chronic setting of autoimmune damage. It ...

journal_title：Immunologic research

authors： Devarajan P,Chen Z

更新日期：2013-12-01 00:00:00

abstract：:Vaccination represents one of the most efficacious and cost-effective medical interventions. It is the only medical intervention proven to eliminate disease at a global level. Many of the pathogens against which we most require adequate vaccines infect via the highly exposed mucosal surfaces. For this reason the mucos...

journal_title：Immunologic research

authors： McKenzie BS,Brady JL,Lew AM

更新日期：2004-01-01 00:00:00

abstract：:Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE ...

journal_title：Immunologic research

authors： Zhong XP,Shin J,Gorentla BK,O'Brien T,Srivatsan S,Xu L,Chen Y,Xie D,Pan H

更新日期：2011-04-01 00:00:00

abstract：:The SH2 domain-containing inositol 5'-phosphatase (SHIP) negatively regulates antigen, cytokine, and Fc receptor signaling pathways in immune cells. Our knowledge of the function of SHIP largely derives from in vitro studies that utilized SHIP-deficient cell lines and immune cells isolated from SHIP null mice. To avoi...

journal_title：Immunologic research

authors： Leung WH,Tarasenko T,Bolland S

更新日期：2009-01-01 00:00:00

abstract：:The indigenous oral microflora and the host are normally in a state of equilibrium; however, the introduction of a pathogen can result in innate and adaptive immune responses that either contribute to the development of the disease or lead to host immunity. The interactions between the microorganisms and the host are ...

journal_title：Immunologic research

authors： Michalek SM,Katz J,Childers NK,Martin M,Balkovetz DF

更新日期：2002-01-01 00:00:00

abstract：:This study investigated nitro-oxidative stress in patients with systemic lupus erythematosus (SLE) in association with disease activity, immune-inflammatory biomarkers, and adhesion molecules. Two-hundred-four patients with SLE and 256 healthy volunteers were enrolled in this case-control study, which measured nitro-o...

journal_title：Immunologic research

authors： Scavuzzi BM,Simão ANC,Iriyoda TMV,Lozovoy MAB,Stadtlober NP,Franchi Santos LFDR,Flauzino T,de Medeiros FA,de Sá MC,Consentin L,Reiche EMV,Maes M,Dichi I

更新日期：2018-02-01 00:00:00

abstract：:Host defense of the lung is characterized by a fine balance between the generation of a vigorous inflammatory response to clear pathogens and maintenance of the integrity of the alveolar gas-exchange surface. The magnitude of the inflammatory response is therefore tightly regulated by pro- and anti-inflammatory cytoki...

journal_title：Immunologic research

authors： Mehrad B,Standiford TJ

更新日期：1999-01-01 00:00:00

abstract：:Dendritic cells (DCs) are considered a very promising arm to activate the immune system in immunotherapeutic strategies against cancer. DCs are the most powerful antigen-presenting cells (APCs), being highly efficient at generating robust immune responses. They are also considered the center of the immune system, sinc...

journal_title：Immunologic research

authors： Constantino J,Gomes C,Falcão A,Neves BM,Cruz MT

更新日期：2017-08-01 00:00:00

abstract：:Mast cells (MC) are important effector cells in allergic disorders. Recently, the role of MC in innate and adaptive immunity is gaining prominence. Nitric oxide is an important signaling molecule and its production in mast cell has been reported widely. However, controversy exists about whether MC produce NO. This rev...

journal_title：Immunologic research

authors： Sekar Y,Moon TC,Muñoz S,Befus AD

更新日期：2005-01-01 00:00:00

abstract：:The role of autoimmune pathology in development and progression of chronic obstructive pulmonary disease (COPD) is becoming increasingly appreciated. In this study, we identified serum autoantibody reactivities associated with chronic bronchitis or emphysema, as well as systemic autoimmunity and associated lung diseas...

journal_title：Immunologic research

authors： Packard TA,Li QZ,Cosgrove GP,Bowler RP,Cambier JC

更新日期：2013-03-01 00:00:00