Abstract：
:Dendritic cells (DCs) are considered a very promising arm to activate the immune system in immunotherapeutic strategies against cancer. DCs are the most powerful antigen-presenting cells (APCs), being highly efficient at generating robust immune responses. They are also considered the center of the immune system, since they provide a crucial link between both innate and adaptive immune responses. Thus, DC-based cancer immunotherapy aims to take advantage of these unique characteristics of DCs to better fight cancer. During the last decade, they have been the subject of numerous studies intending to develop immunotherapeutic strategies against cancer through vaccination. For this purpose, it is essential to gain a better insight into DC immunobiology, regulation of innate and adaptive immune systems, and tumor microenvironment, as well as applying the latest advances in science in order to boost their enormous anti-tumor immunotherapeutic potential. In this review, we will hold focus on DC immunobiology (from their origin, location, and special properties and distinct subsets to the innate and adaptive immunity), on the new concept of cancer immunoediting, and on the knowledge given by clinical trials using DC vaccines. Finally, future perspectives for this emerging field are highlighted.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Constantino J,Gomes C,Falcão A,Neves BM,Cruz MTdoi
10.1007/s12026-017-8931-1subject
Has Abstractpub_date
2017-08-01 00:00:00pages
798-810issue
4eissn
0257-277Xissn
1559-0755pii
10.1007/s12026-017-8931-1journal_volume
65pub_type
杂志文章,评审abstract：:We examine whether B cell lines enriched for DNA specificity from either autoimmune (BWF1) or normal mice (Balb/c) can be rendered unresponsive to autoantigen in terms of the specific suppression of direct antibody-forming cells to DNA. These B cell lines were both Lyt-1 positive and negative. Preincubation with oligo...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/BF02935511
更新日期：1989-01-01 00:00:00
abstract：:Considerable progress has been made in understanding the Fas pathway at the molecular and cellular levels, but fundamental questions about the overall biological role of the Fas pathway remain unresolved. A major question is why lymphoproliferation caused by the lpr mutation of Fas and gld mutation of FasL ligand (Fas...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8144-3
更新日期：2010-07-01 00:00:00
abstract：:Major histocompatibility (MHC) class II molecules function to present antigenic peptides to CD4 T lymphocytes. The pathways by which these molecules present exogenous antigens have been extensively studied. However by contrast, far less is known about the processing and trafficking of cytosolic antigens, which can als...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:30:3:279
更新日期：2004-01-01 00:00:00
abstract：:In the murine splenocytes, CD8α+ dendritic cells (abbreviated as 8+DC) and CD8α- dendritic cells (abbreviated as 8-DC) are identified with some vague features for each of them. 8+DCs but not 8-DCs cross-prime cytotoxic T cells in vivo. We aim to distinguish the two subtypes of DC based on gene expression profiling. Su...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-011-8237-7
更新日期：2011-10-01 00:00:00
abstract：:Increased numbers of CD8+CD28neg. T cells have been detected in the peripheral blood of patients with several types of malignancies. However, the role of these cells in anticancer immunity are not yet clear and CD8+CD28neg. T cells are a controversially discussed subpopulation reported both as immunosuppressive and cy...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8976-1
更新日期：2018-02-01 00:00:00
abstract：:Consideration of the pathophysiology of insulin-dependent diabetes mellitus in the nonobese diabetic (NOD) mouse can be viewed from a temporal perspective. We argue that there are discontinuous phases and each phase may reflect a phenotype educed by a particular set of genetic and epigenetic events. Therefore, tempora...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786358
更新日期：1997-01-01 00:00:00
abstract：:Major conceptual roadblocks impede the development of an HIV-1 vaccine that can stimulate a potent neutralizing antibody response. Animal models that support HIV-1 replication and allow for host genetic manipulation would be an ideal platform for testing various immunological hypotheses, but progress on this research ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8370-y
更新日期：2013-03-01 00:00:00
abstract：:Kv1.3 and IKCa1 lymphocyte potassium channels have been implicated as important targets of selective immunomodulation. We compared the alterations in cytokine production upon selective inhibition of Kv1.3 or IKCa1 channels (by MGTX and TRAM, respectively) in healthy donors (HD), RA and AS patients. We also determined ...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8683-8
更新日期：2016-04-01 00:00:00
abstract：:An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is not well understood...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-010-8164-z
更新日期：2010-12-01 00:00:00
abstract：:Allergic asthma is a chronic disease of the lung characterized by underlying Th2- and IgE-mediated inflammation, structural alterations of the bronchial wall, and airway hyperresponsiveness. Initial allergic sensitization and later development of chronic disease are determined by close interactions between lung struct...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8296-4
更新日期：2012-09-01 00:00:00
abstract：:There is increasing documentation of significant survival benefits achieved in cancer patients treated with hyperthermia in combination with radiation and/or chemotherapy. Most evidence collected regarding the mechanisms by which hyperthermia positively influences tumor control has centered on in vitro data showing th...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8115-8
更新日期：2010-03-01 00:00:00
abstract：:Systemic lupus erythematosus is a severe autoimmune disease that affects multiple organ systems resulting in diverse symptoms and outcomes. It is characterized by antibody production to a variety of self-antigens, but it is specifically associated with those against anti-dsDNA. Anti-dsDNA antibodies are present before...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8345-z
更新日期：2013-03-01 00:00:00
abstract：:Anti-double-stranded DNA (dsDNA) B cells persist even in nonautoimmune- prone animals. In this review, we summarize data regarding the activation potential of these cells. Provision of cognate CD4 T cell help to anti-dsDNA B cells in nonautoimmune mice not only drives their maturation and entry into the B cell follicl...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:27:2-3:219
更新日期：2003-01-01 00:00:00
abstract：:Adenosine suppresses the production of various cytokines/ chemokines and inhibits the cytotoxic activity of murine and human NK cells activated with IL-2 or Ly49D, NKp46-receptor crosslinking, respectively. These effects are mediated by the type A2A adenosine receptor via stimulation of adenylyl cyclase, increased pro...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:36:1:91
更新日期：2006-01-01 00:00:00
abstract：:Primate complement receptor type 1 (CR1) protein, a single-chain transmembrane glycoprotein, plays an important role in immune adherence and clearing complement-opsonized immune complexes. Here, the mRNA of the porcine primate-like complement receptor (CR1-like) gene was analyzed, and two domain sequences with potenti...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8792-z
更新日期：2016-08-01 00:00:00
abstract：:Primary immunodeficiencies (PI) are genetic defects of the immune system that result in chronic, serious, and often life-threatening infections, if not diagnosed and treated. Many patients with PI are undiagnosed, underdiagnosed, or misdiagnosed. In fact, recent studies have shown that PI may be more common than previ...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-8996-5
更新日期：2018-06-01 00:00:00
abstract：:We have recently established new bone marrow transplantation (BMT) methods for the treatment of intractable diseases. The methods include the perfusion method (PM) for the collection of bone marrow cells, and intra-bone marrow (IBM)-BMT for the direct injection of collected whole bone marrow cells into the bone marrow...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-007-0004-4
更新日期：2007-01-01 00:00:00
abstract：:Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-016-8836-4
更新日期：2017-02-01 00:00:00
abstract：:The "X chromosome-nucleolus nexus" hypothesis provides a comprehensive explanation of how autoantibodies can develop following cellular stress. The hypothesis connects autoimmune diseases with the impact of environmental factors, such as viruses, through epigenetic disruption. The inactive X chromosome, a major epigen...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-018-9044-1
更新日期：2018-12-01 00:00:00
abstract：:Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to stu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8136-3
更新日期：2010-07-01 00:00:00
abstract：:Antimicrobial peptide innate immunity plays a central role in the susceptibility to infectious diseases, as has been described extensively in different settings. However, the role that these molecules play in the immunity mediated by polymorphonuclear phagocytes as part of the innate immunity of ageing individuals has...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8689-2
更新日期：2016-04-01 00:00:00
abstract：:The two-signal model of T cell activation states that antigen recognition by TCR provides a tolerogenic signal (termed Signal 1) unless the T cell receives simultaneous costimulation (Signal 2) that permits antigen recognition to prime activation. Our efforts to characterize genetic and biochemical factors resulting f...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8147-0
更新日期：2010-07-01 00:00:00
abstract：:The erbB family of receptor tyrosine kinases are growth factor receptors that are overexpressed or mutated in a large variety of human cancers. Studies of erbB-mediated signal transduction will lead to an understanding of the role played by this family of receptors in normal and transformed cells. In this article, we ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786443
更新日期：1998-01-01 00:00:00
abstract：:The intestinal epithelium serves as one of human's primary interfaces with the outside world. This interface is very heavily colonized with bacteria and yet permits absorption of life-sustaining nutrients while protecting the tissues below from microbial onslaught. Although the gut epithelium had been classically thou...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:29:1-3:055
更新日期：2004-01-01 00:00:00
abstract：:The University of Pittsburgh School of Medicine has a long tradition of excellence in immunology research and training. Faculty, students, and postdoctoral fellows walk through hallways that are pictorial reminders of the days when Dr. Jonas Salk worked here to develop the polio vaccine, or when Dr. Niels Jerne chaire...
journal_title：Immunologic research
pub_type： 历史文章,杂志文章
doi：10.1385/IR:36:1:1
更新日期：2006-01-01 00:00:00
abstract：:Cell-penetrating peptides (CPP) or membrane-translocating peptides such as penetratin from Antennapedia homeodomain or TAT from human immunodeficiency virus are useful vectors for the delivery of protein antigens or their cytotoxic (Tc) or helper (Th) T cell epitopes to antigen-presenting cells. Mice immunized with CP...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8799-5
更新日期：2016-08-01 00:00:00
abstract：:The human mayor histocompatibility complex class I molecule HLA-A2 preferentially binds peptides that contain Leu at P2 and Val or Leu at the C terminus. The other amino acids in the peptide also contribute to binding positively or negatively. It is possible to estimate the binding stability of HLA-A2 complexes contai...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918496
更新日期：1995-01-01 00:00:00
abstract：:C3d is the final degradation product of the third component of complement (C3). When conjugated to an antigen, C3d enhances immune responses to the fused antigen. Therefore, this molecule has been used as an adjuvant to enhance the immune responses to various foreign and self-proteins. C3d binds to the complement rece...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:36:1:197
更新日期：2006-01-01 00:00:00
abstract：:The participation of inflammatory cells in atherosclerosis is a well-known process that involves numerous molecules including chemotactic cytokines (chemokines) for their entry into the vessel wall. Although the C-C chemokine monocyte chemoattractant protein-1 and its receptor, CCR2, have been implicated in atheroscle...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/ir:21:2-3:129
更新日期：2000-01-01 00:00:00
abstract：:The indigenous oral microflora and the host are normally in a state of equilibrium; however, the introduction of a pathogen can result in innate and adaptive immune responses that either contribute to the development of the disease or lead to host immunity. The interactions between the microorganisms and the host are ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:26:1-3:223
更新日期：2002-01-01 00:00:00
