The genetic profiling of preferentially expressed genes in murine splenic CD8α+ dendritic cells.

abstract：:Allogeneic hematopoietic cell transplantation has developed into a most successful form of immunotherapy for hematologic malignancies in the past 50 years. However, its effectiveness and wider applications have been greatly limited by the development of graft-versus-host disease (GVHD), a potentially lethal side effec...

journal_title：Immunologic research

authors： Zhang P,Chen BJ,Chao NJ

更新日期：2011-04-01 00:00:00

abstract：:Human leukocytes, including macrophages and neutrophils, are phagocytic immune cells that capture and engulf pathogens and subsequently destroy them in intracellular vesicles. To accomplish this vital task, these leukocytes utilize two basic cell behaviors-chemotaxis for chasing down infectious pathogens and phagocyto...

journal_title：Immunologic research

authors： Jin T,Xu X,Fang J,Isik N,Yan J,Brzostowski JA,Hereld D

更新日期：2009-01-01 00:00:00

abstract：:The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and...

journal_title：Immunologic research

authors： Conti P,Caraffa A,Ronconi G,Conti CM,Kritas SK,Mastrangelo F,Tettamanti L,Theoharides TC

更新日期：2018-06-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well as prime disparate T-cell helper responses. Yet, there is increasing e...

journal_title：Immunologic research

authors： Barchet W,Blasius A,Cella M,Colonna M

更新日期：2005-01-01 00:00:00

abstract：:The human thymus is required for establishment of a normal T cell repertoire in fetal development, as children born without a thymus (DiGeorge Syndrome) lack thymus-derived (T) and T cell immunity. While the function of the thymus in children for production of new T cells is clear, it has not been obvious that the adu...

journal_title：Immunologic research

authors： Haynes BF,Sempowski GD,Wells AF,Hale LP

更新日期：2000-01-01 00:00:00

abstract：:Morphological data in humans and rodents and functional data of intraepithelial lymphocytes of mice support the idea that cytotoxic cells are a significant population of the human mucosa. Previously it was shown that human IEL have no spontaneous cell-mediated cytotoxicity and that human LPL cells have anti-CD3-mediat...

journal_title：Immunologic research

authors： Rüthlein J,Heinze G

更新日期：1991-01-01 00:00:00

abstract：:The etiology and immunologic states of autoimmune diseases have mainly been discussed without consideration of extrathymic T cells, which exist in the liver, intestine, and excretion glands. Because extrathymic T cells are autoreactive and are often simultaneously activated along with autoantibody-producing B-1 cells,...

journal_title：Immunologic research

authors： Abo T,Kawamura T,Watanabe H

更新日期：2005-01-01 00:00:00

abstract：:We examine whether B cell lines enriched for DNA specificity from either autoimmune (BWF1) or normal mice (Balb/c) can be rendered unresponsive to autoantigen in terms of the specific suppression of direct antibody-forming cells to DNA. These B cell lines were both Lyt-1 positive and negative. Preincubation with oligo...

journal_title：Immunologic research

authors： Aldo-Benson M,Borel H,Scheiderer-Pratt L,Borel Y

更新日期：1989-01-01 00:00:00

abstract：:Antimicrobial peptide innate immunity plays a central role in the susceptibility to infectious diseases, as has been described extensively in different settings. However, the role that these molecules play in the immunity mediated by polymorphonuclear phagocytes as part of the innate immunity of ageing individuals has...

journal_title：Immunologic research

authors： Rivas-Santiago B,Castañeda-Delgado JE,de Haro-Acosta J,Torres-Juarez F,Frausto-Lujan I,Marin-Luevano P,González-Amaro R,Enciso-Moreno JA

更新日期：2016-04-01 00:00:00

abstract：:The coexistence of alopecia areata (AA) and systemic lupus erythematosus (SLE) has been described, but the association between these conditions is yet to be firmly established. We aimed to evaluate the association between AA and SLE using a large-scale real-life computerized database. A cross-sectional study was condu...

journal_title：Immunologic research

authors： Kridin K,Shalom G,Comaneshter D,Cohen AD

更新日期：2020-02-01 00:00:00

abstract：:p-Phenylenediamine (PPD) and Diphenylcyclopropenone (DPCP) are two potent haptens. Both haptens are known to cause delayed-type hypersensitivity, involving a cytokine response and local infiltration of T-cell subpopulations, resulting in contact dermatitis. We investigated the systemic immune effects of PPD and DPCP, ...

journal_title：Immunologic research

authors： Svalgaard JD,Særmark C,Dall M,Buschard K,Johansen JD,Engkilde K

更新日期：2014-01-01 00:00:00

abstract：:Although the B-cell antigen receptor (BCR) factors most prominently in the maintenance and differentiation of mature B cells, it is now appreciated that co-receptor molecules can positively or negatively modulate signals through the BCR. Co-receptors are functionally defined as modifiers of BCR engagement and signal t...

journal_title：Immunologic research

authors： Del Nagro CJ,Otero DC,Anzelon AN,Omori SA,Kolla RV,Rickert RC

更新日期：2005-01-01 00:00:00

abstract：:Acute graft-versus-host disease (aGvHD) is still a major cause of transplant-related mortality after allogeneic stem cell transplantation (ASCT). It requires immunosuppressive treatments that broadly abrogate T cell responses including beneficial ones directed against tumor cells or infective pathogens. Polo-like kina...

journal_title：Immunologic research

authors： Berges C,Chatterjee M,Topp MS,Einsele H

更新日期：2016-06-01 00:00:00

abstract：:The transcription factor Blimp-1 is necessary for the B cell differentiation toward immunoglobulin-secreting plasma cells. However, the immunopathological mechanisms of Blimp-1 that regulates B cell differentiation remain unclear in MG. The purpose of this study was to perform a quantitative and functional analysis of...

journal_title：Immunologic research

authors： Xu Y,Huang X,Li F,Liu T,Yang T,Chen F,Zhu J,Pan M,Zhang Y,Wang Y,Fu L,Xiao C,Geng D

更新日期：2020-11-03 00:00:00

abstract：:The follicular helper T cell (Tfh) and IL-21 have been shown to play an important role in many autoimmune diseases. However, less is known about their role in Graves' disease (GD). This study aimed to investigate the expression of Tfhs and related factors (IL-21, IL-21R, CXCR5, and CXCL13) in GD thyroid tissues and to...

journal_title：Immunologic research

authors： Zhang J,Ren M,Zeng H,Guo Y,Zhuang Z,Feng Z,Yan H,Xu M,Liang W,Yang C,Cheng H,Ding H,Yan L

更新日期：2015-06-01 00:00:00

abstract：:Allergic asthma is a chronic disease of the lung characterized by underlying Th2- and IgE-mediated inflammation, structural alterations of the bronchial wall, and airway hyperresponsiveness. Initial allergic sensitization and later development of chronic disease are determined by close interactions between lung struct...

journal_title：Immunologic research

authors： Ramakrishna L,de Vries VC,Curotto de Lafaille MA

更新日期：2012-09-01 00:00:00

abstract：:Nitric oxide (.NO) is a freely diffusible inter- and intracellular messenger produced by a variety of mammalian cells including vascular endothelium, neurons, smooth muscle cells, macrophages, neutrophils, platelets, and pulmonary epithelium. In smooth muscle cells, platelets, and neutrophils, .NO raises intracellular...

journal_title：Immunologic research

authors： Aslan M,Freeman BA

更新日期：2002-01-01 00:00:00

abstract：:In recent years, there has been a profound change in autoimmune diagnostics. From long, tiring and inaccurate manual methods, the art of diagnostics has turned to modern, rapid and automated technology. New antibody tests have been developed, and almost all autoimmune diseases now have some specific diagnostic markers...

journal_title：Immunologic research

authors： Bizzaro N,Tozzoli R,Villalta D

更新日期：2015-02-01 00:00:00

abstract：:Increased numbers of CD8+CD28neg. T cells have been detected in the peripheral blood of patients with several types of malignancies. However, the role of these cells in anticancer immunity are not yet clear and CD8+CD28neg. T cells are a controversially discussed subpopulation reported both as immunosuppressive and cy...

journal_title：Immunologic research

authors： Hashimoto H,Sterk M,Schilbach K

更新日期：2018-02-01 00:00:00

abstract：:Major histocompatibility (MHC) class II molecules function to present antigenic peptides to CD4 T lymphocytes. The pathways by which these molecules present exogenous antigens have been extensively studied. However by contrast, far less is known about the processing and trafficking of cytosolic antigens, which can als...

journal_title：Immunologic research

authors： Zhou D,Blum JS

更新日期：2004-01-01 00:00:00

abstract：:Soybeans are rich in immuno-modulatory isoflavones such as genistein, daidzein, and glycitein. These isoflavones are well-known antioxidants, chemopreventive and anti-inflammatory agents. Several epidemiological studies suggest that consumption of traditional soy food containing isoflavones is associated with reduced ...

journal_title：Immunologic research

authors： Masilamani M,Wei J,Sampson HA

更新日期：2012-12-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a chronic autoimmune disease in which β cells are destroyed. Islet transplantation is the most promising therapeutic treatment for T1D patients. However, allograft rejection and autoimmune reaction have been recognized as primary causes of graft loss after transplantation. Alpha-1-antitrypsin ...

journal_title：Immunologic research

authors： Yang L,Liao YT,Yang XF,Reng LW,Qi H,Li FR

更新日期：2015-05-01 00:00:00

abstract：:Recent advances in molecular medicine have shown that soluble MHC-multimers can be valuable tools for both analysis and modulation of antigen-specific immune responses in vitro and in vivo. In this review, we describe the use of dimeric human and mouse major histocompatibility complexes, MHC-Ig, as part of an artifici...

journal_title：Immunologic research

authors： Oelke M,Schneck JP

更新日期：2010-07-01 00:00:00

abstract：:Risk posed by microbial superantigens in triggering or exacerbating SLE in genetically predisposed individuals, thereby altering the response to its treatment strategies, has not been studied. Using streptococcal pyrogenic exotoxin A and staphylococcal enterotoxin B as prototype superantigens, we have demonstrated tha...

journal_title：Immunologic research

authors： Dar SA,Janahi EM,Haque S,Akhter N,Jawed A,Wahid M,Ramachandran VG,Bhattacharya SN,Banerjee BD,Das S

更新日期：2016-08-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a T cell mediated demyelinating disease of the central nervous system (CNS) that serves as a model for multiple sclerosis (MS). Insights into the pathogenesis of this model may help scientists understand the human disease and aid in rational drug discovery. In this re...

journal_title：Immunologic research

authors： Elhofy A,Kennedy KJ,Fife BT,Karpus WJ

更新日期：2002-01-01 00:00:00

abstract：:Mast cells (MC) are important effector cells in allergic disorders. Recently, the role of MC in innate and adaptive immunity is gaining prominence. Nitric oxide is an important signaling molecule and its production in mast cell has been reported widely. However, controversy exists about whether MC produce NO. This rev...

journal_title：Immunologic research

authors： Sekar Y,Moon TC,Muñoz S,Befus AD

更新日期：2005-01-01 00:00:00

abstract：:Genes of the major histocompatibility complex (MHC) are one of the most significant genetic predictors of HIV and SIV disease outcome; however, in no case is MHC genotype alone sufficient to account for this durable HIV/SIV control. Killer immunoglobulin-like receptors (KIRs) interact with MHC molecules and have been ...

journal_title：Immunologic research

authors： Bimber B,O'Connor DH

更新日期：2008-01-01 00:00:00

abstract：:Interleukin (IL)-21 is a member of the γ chain-receptor cytokine family along with IL-2, IL-4, IL-7, IL-9, and IL-15. The effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. IL-21 is secreted by activated CD4 T cells and natural killer T cells. Within CD4 T cells, its secr...

journal_title：Immunologic research

authors： Pallikkuth S,Pahwa S

更新日期：2013-12-01 00:00:00

abstract：:Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE ...

journal_title：Immunologic research

authors： Zhong XP,Shin J,Gorentla BK,O'Brien T,Srivatsan S,Xu L,Chen Y,Xie D,Pan H

更新日期：2011-04-01 00:00:00

abstract：:Chronic infections have been a major topic of investigation in recent years, but the mechanisms that dictate whether or not a pathogen is successfully controlled are incompletely understood. Cytomegalovirus (CMV) is a herpesvirus that establishes a persistent infection in the majority of people in the world. Like othe...

journal_title：Immunologic research

authors： Snyder CM

更新日期：2011-12-01 00:00:00