Vaccine delivery by penetratin: mechanism of antigen presentation by dendritic cells.

abstract：:WASP, the product of the gene mutated in Wiskott-Aldrich syndrome, is expressed only in hematopoietic cells and is the archetype of a family of proteins that include N-WASP and Scar/WAVE. WASP plays a critical role in T cell activation and actin reorganization. WASP has multiple protein-interacting domains. Through it...

journal_title：Immunologic research

authors： Ramesh N,Geha R

更新日期：2009-01-01 00:00:00

abstract：:Pemphigus foliaceus (PF) and Behçet's disease (BD) are immune-mediated conditions which are usually treated with corticosteroids, immunosuppressants, and, when refractory, with biologic agents. In both diseases, interleukin (IL)-6 serum levels are increased driving the immune-mediated inflammatory process. Tocilizumab...

journal_title：Immunologic research

authors： Caso F,Iaccarino L,Bettio S,Ometto F,Costa L,Punzi L,Doria A

更新日期：2013-07-01 00:00:00

abstract：:Chronic infections have been a major topic of investigation in recent years, but the mechanisms that dictate whether or not a pathogen is successfully controlled are incompletely understood. Cytomegalovirus (CMV) is a herpesvirus that establishes a persistent infection in the majority of people in the world. Like othe...

journal_title：Immunologic research

authors： Snyder CM

更新日期：2011-12-01 00:00:00

abstract：:The coexistence of alopecia areata (AA) and systemic lupus erythematosus (SLE) has been described, but the association between these conditions is yet to be firmly established. We aimed to evaluate the association between AA and SLE using a large-scale real-life computerized database. A cross-sectional study was condu...

journal_title：Immunologic research

authors： Kridin K,Shalom G,Comaneshter D,Cohen AD

更新日期：2020-02-01 00:00:00

abstract：:We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all environmental factors contributing to the development of disease and studies the sum total of bur...

journal_title：Immunologic research

authors： Bogdanos DP,Smyk DS,Invernizzi P,Rigopoulou EI,Blank M,Sakkas L,Pouria S,Shoenfeld Y

更新日期：2013-07-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a ubiquitous human gamma-herpesvirus that establishes life-long latency and is associated with lymphoproliferative disorders and the development of several malignancies. EBV infection is frequently, but not always, associated with the development of a syndrome termed infectious mononucleosi...

journal_title：Immunologic research

authors： Flaño E,Woodland DL,Blackman MA

更新日期：2002-01-01 00:00:00

abstract：:Modulating PI3K at different stages of dendritic cells (DC) generation could be a novel means to balance the generation of immunosuppressive versus immunostimulatory DC. We show that PI3K inhibition during mouse DC generation in vitro results in cells that are potently immunosuppressive and characteristic of CD8alpha-...

journal_title：Immunologic research

authors： Di Caro V,D'Anneo A,Phillips B,Engman C,Harnaha J,Trucco M,Giannoukakis N

更新日期：2011-08-01 00:00:00

abstract：:p-Phenylenediamine (PPD) and Diphenylcyclopropenone (DPCP) are two potent haptens. Both haptens are known to cause delayed-type hypersensitivity, involving a cytokine response and local infiltration of T-cell subpopulations, resulting in contact dermatitis. We investigated the systemic immune effects of PPD and DPCP, ...

journal_title：Immunologic research

authors： Svalgaard JD,Særmark C,Dall M,Buschard K,Johansen JD,Engkilde K

更新日期：2014-01-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) currently provides the only chance of curative therapy for many patients with hematological malignancies. Owing to the excess morbidity and mortality observed in less robust patients, this approach has traditionally been limited to younger patients without sign...

journal_title：Immunologic research

authors： Hogan WJ,Storb R

更新日期：2003-01-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well as prime disparate T-cell helper responses. Yet, there is increasing e...

journal_title：Immunologic research

authors： Barchet W,Blasius A,Cella M,Colonna M

更新日期：2005-01-01 00:00:00

abstract：:Acute graft-versus-host disease (aGvHD) is still a major cause of transplant-related mortality after allogeneic stem cell transplantation (ASCT). It requires immunosuppressive treatments that broadly abrogate T cell responses including beneficial ones directed against tumor cells or infective pathogens. Polo-like kina...

journal_title：Immunologic research

authors： Berges C,Chatterjee M,Topp MS,Einsele H

更新日期：2016-06-01 00:00:00

abstract：:The role of gamma/delta T cells in immunity to bacterial infection and control of inflammation is discussed. Special emphasis is placed on the use of murine models in which various aspects of immune function can be monitored in the absence of gamma/delta T cells. Issues discussed include the response to and control of...

journal_title：Immunologic research

authors： Ziegler HK

更新日期：2004-01-01 00:00:00

abstract：:Rituximab is a chimeric monoclonal anti-CD20 antibody and was the first monoclonal antibody (mAb) therapy approved by FDA (Food and Drug Administration) for the treatment of B-cell lymphoma. It has revolutionized the treatment of patients with CD20-positive non-Hodgkin's lymphoma and CLL. Rituximab is currently being ...

journal_title：Immunologic research

authors： Riaz W,Hernandez-Ilizaliturri FJ,Czuczman MS

更新日期：2010-03-01 00:00:00

abstract：:Recent research on hematological malignancies has shown that malignant cells often co-opt physiological pathways to promote their growth and development. Bone marrow homeostasis requires a fine balance between cellular differentiation and self-renewal; cell survival and apoptosis; and cellular proliferation and senesc...

journal_title：Immunologic research

authors： Chung E,Kondo M

更新日期：2011-04-01 00:00:00

abstract：:The tick-borne encephalitis (TBE) serocomplex of viruses, genus Flavivirus, includes a number of important human pathogens that cause serious neurological illnesses and hemorrhagic fevers. These viruses pose a significant public health problem due to high rates of morbidity and mortality, their emergence to new geogra...

journal_title：Immunologic research

authors： Robertson SJ,Mitzel DN,Taylor RT,Best SM,Bloom ME

更新日期：2009-01-01 00:00:00

abstract：:We have used MAb to L3T4 to examine the function of L3T4+ T cells in normal and autoimmune mice. Treatment of mice with MAb to L3T4 profoundly depleted L3T4+ cells from the blood, spleen, and lymph nodes, but not the thymus. In BALB/c and C57BL/6 mice, selective depletion of L3T4+ cells blocked both primary and second...

journal_title：Immunologic research

authors： Wofsy D,Seaman WE

更新日期：1986-01-01 00:00:00

abstract：:In performing host-defense functions, cells of the immune system become activated by soluble chemokine signals and must migrate through endothelial cell or solid tissue barriers to reach sites of inflammation or infection. Regulated adhesive interactions of immune cells with endothelium, extracellular matrix component...

journal_title：Immunologic research

authors： Hauck CR,Klingbeil CK,Schlaepfer DD

更新日期：2000-01-01 00:00:00

abstract：:The follicular helper T cell (Tfh) and IL-21 have been shown to play an important role in many autoimmune diseases. However, less is known about their role in Graves' disease (GD). This study aimed to investigate the expression of Tfhs and related factors (IL-21, IL-21R, CXCR5, and CXCL13) in GD thyroid tissues and to...

journal_title：Immunologic research

authors： Zhang J,Ren M,Zeng H,Guo Y,Zhuang Z,Feng Z,Yan H,Xu M,Liang W,Yang C,Cheng H,Ding H,Yan L

更新日期：2015-06-01 00:00:00

abstract：:The aim of the present study was to examine the role and mechanism of interleukin-10 (IL-10)-producing regulatory B cells (B10 cells) in the pathogenesis of Henoch-Schönlein purpura nephritis (HSPN). We examined the percentage of B10 cells, CD19+CD24hiCD38hi B cells, CD19+CD24hiCD27+ B cells, Th17 cells, and T regulat...

journal_title：Immunologic research

authors： Yang B,Tan X,Xiong X,Wu D,Zhang G,Wang M,Dong S,Liu W,Yang H,Li Q

更新日期：2017-06-01 00:00:00

abstract：:Purified protein derivative (PPD) or tuberculin skin testing is used to identify infected individuals with Mycobacterium tuberculosis (Mtb) and to assess cell-mediated immunity to Mtb. In the present study, we compared PBMC cultures in the presence of tuberculin or Candida antigens using cytokine bead arrays and RNA m...

journal_title：Immunologic research

authors： Stern JN,Keskin DB,Romero V,Zuniga J,Encinales L,Li C,Awad C,Yunis EJ

更新日期：2009-01-01 00:00:00

abstract：:It has long been known that T cells have the potential to modulate hematopoietic response in different ways. More recently, the importance of interleukin (IL)-17-secreting Th17 cells in T-cell-mediated regulation of hematopoiesis was indicated by the line of evidence that IL-17 links T-cell function and hematopoiesis ...

journal_title：Immunologic research

authors： Krstic A,Mojsilovic S,Jovcic G,Bugarski D

更新日期：2012-04-01 00:00:00

abstract：:Allogeneic hematopoietic cell transplantation has developed into a most successful form of immunotherapy for hematologic malignancies in the past 50 years. However, its effectiveness and wider applications have been greatly limited by the development of graft-versus-host disease (GVHD), a potentially lethal side effec...

journal_title：Immunologic research

authors： Zhang P,Chen BJ,Chao NJ

更新日期：2011-04-01 00:00:00

abstract：:In our laboratory we study the mechanisms by which the immune system controls viral infection and by which viruses evade immune control. To study issues at this interface between virology and immunology, we work from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicat...

journal_title：Immunologic research

authors： Virgin HW

更新日期：2005-01-01 00:00:00

abstract：:Consideration of the pathophysiology of insulin-dependent diabetes mellitus in the nonobese diabetic (NOD) mouse can be viewed from a temporal perspective. We argue that there are discontinuous phases and each phase may reflect a phenotype educed by a particular set of genetic and epigenetic events. Therefore, tempora...

journal_title：Immunologic research

authors： Rudy GB,Sutherland RM,Lew AM

更新日期：1997-01-01 00:00:00

abstract：:Eukaryotic cells perceive and respond to microbes, both pathogenic and commensal, by activation of signaling cascades such as the NF-kappaB pathway. Induction of such pathways leads to the upregulation of a program of gene expression that mediates pro-inflammatory and anti-apoptotic effector proteins. This host respon...

journal_title：Immunologic research

authors： Neish AS

更新日期：2004-01-01 00:00:00

abstract：:Apoptosis, programmed cell death, eliminates injured or harmful cells. It can mediate its response through the actions of death ligands including TRAIL. TRAIL, a member of TNF superfamily, induces apoptosis of transformed cells through the action of death domain receptors DR-4 and DR5. It directly induces apoptosis th...

journal_title：Immunologic research

authors： Chaudhari BR,Murphy RF,Agrawal DK

更新日期：2006-01-01 00:00:00

abstract：:The attributes of specificity and memory enable CD8(+) T cells to provide long-lasting protection against a variety of challenges. Although, the importance of CD8(+) T cells for protection against intracellular infections and transformation is well-established, the functional type; effector phenotypes (Tc1, Tc2, Tc17 ...

journal_title：Immunologic research

authors： Shrikant PA,Rao R,Li Q,Kesterson J,Eppolito C,Mischo A,Singhal P

更新日期：2010-03-01 00:00:00

abstract：:Psoriasis is a common chronic T-cell-mediated autoimmune skin disease, and traditional immunotherapies for psoriasis have focused on the direct inhibition of T cells, which often causes toxicity and lacks long-term effectiveness. Safe and effective therapeutic strategies are strongly needed for psoriasis. In this stud...

journal_title：Immunologic research

authors： Yan HX,Li WW,Zhang Y,Wei XW,Fu LX,Shen GB,Yin T,Li XY,Shi HS,Wan Y,Zhang QY,Li J,Yang SY,Wei YQ

更新日期：2014-10-01 00:00:00

abstract：:Major histocompatibility (MHC) class II molecules function to present antigenic peptides to CD4 T lymphocytes. The pathways by which these molecules present exogenous antigens have been extensively studied. However by contrast, far less is known about the processing and trafficking of cytosolic antigens, which can als...

journal_title：Immunologic research

authors： Zhou D,Blum JS

更新日期：2004-01-01 00:00:00

abstract：:Monoclonal antibodies (mAb) have been used as targeted treatments against cancer for more than a decade, with mixed results. Research is needed to understand mAb mechanisms of action with the goal of improving the efficacy of currently used mAbs and guiding the design of novel mAbs. While some mAb-induced tumor cell k...

journal_title：Immunologic research

authors： Rogers LM,Veeramani S,Weiner GJ

更新日期：2014-08-01 00:00:00