Abstract：
:Allogeneic hematopoietic cell transplantation has developed into a most successful form of immunotherapy for hematologic malignancies in the past 50 years. However, its effectiveness and wider applications have been greatly limited by the development of graft-versus-host disease (GVHD), a potentially lethal side effect associated with this procedure. Since the main effectors for both graft-versus-leukemia (GVL) effect and GVHD are T lymphocytes and these two processes share many similar pathways, it has not been easy to separate GVL from GVHD. Because the clinically used pan immunosuppressive therapy for GVHD prevention also results in decreased GVL effect, the success of allogeneic hematopoietic cell transplantation relies on a small and unpredictable therapeutic window at the present time. This review discusses how we may widen this therapeutic window so that we can reliably prevent GVHD without losing GVL effect.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Zhang P,Chen BJ,Chao NJdoi
10.1007/s12026-010-8193-7subject
Has Abstractpub_date
2011-04-01 00:00:00pages
49-55issue
1-3eissn
0257-277Xissn
1559-0755journal_volume
49pub_type
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