Recent advances in the biology of WASP and WIP.

abstract：:Contrasting results have been reported about the prevalence of thyroid autoimmunity (AT) and dysfunction (TD) in patients with psoriatic arthritis (PsA). In this study, we pointed to evaluate the incidence of new cases of clinical and subclinical TD in a broad group of patients with PsA versus a control group, matched...

journal_title：Immunologic research

authors： Fallahi P,Ferrari SM,Ruffilli I,Elia G,Miccoli M,Sedie AD,Riente L,Antonelli A

更新日期：2017-06-01 00:00:00

abstract：:Upon entry to the systemic circulation, neutrophils exhibit a short mean time to cell death. The viability of most cell types in a steady state is preserved by the interplay of the Bcl-2 family of proteins, wherein the anti-apoptotic members inhibit the action of their pro-apoptotic counterparts. Neutrophils, however,...

journal_title：Immunologic research

authors： Murphy MP,Caraher E

更新日期：2015-06-01 00:00:00

abstract：:Schizophrenia is considered to be of the severe psychiatric disorders characterized by chronic debilitating course marked with frequent relapses and high clinical and financial burden. Aberrations of thyroid hormone levels have been documented in several psychiatric conditions including bipolar disease. The aim of thi...

journal_title：Immunologic research

authors： Sharif K,Tiosano S,Watad A,Comaneshter D,Cohen AD,Shoenfeld Y,Amital H

更新日期：2018-12-01 00:00:00

abstract：:With several different CAR T cell therapies under advanced phases of clinical trials, and the first FDA-approved CAR treatments in 2017 (Yescarta and Kymriah), CAR T cell therapy has become one of the most promising therapies for the treatment of certain types of cancer. This success has bred an opportunity to optimiz...

journal_title：Immunologic research

authors： Townsend MH,Bennion K,Robison RA,O'Neill KL

更新日期：2020-02-01 00:00:00

abstract：:Major histocompatibility (MHC) class II molecules function to present antigenic peptides to CD4 T lymphocytes. The pathways by which these molecules present exogenous antigens have been extensively studied. However by contrast, far less is known about the processing and trafficking of cytosolic antigens, which can als...

journal_title：Immunologic research

authors： Zhou D,Blum JS

更新日期：2004-01-01 00:00:00

abstract：:We describe herein a 61-year-old woman who presented with fever, night sweats and cough. The diagnosis of pneumonia was established, but with symptom recurrence following antibiotic therapy, further diagnostics were performed. Biopsy via bronchoscopy revealed cryptogenic organizing pneumonia, and later on follow-up, a...

journal_title：Immunologic research

authors： Gueta I,Shoenfeld Y,Orbach H

更新日期：2014-12-01 00:00:00

abstract：:In our laboratory we study the mechanisms by which the immune system controls viral infection and by which viruses evade immune control. To study issues at this interface between virology and immunology, we work from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicat...

journal_title：Immunologic research

authors： Virgin HW

更新日期：2005-01-01 00:00:00

abstract：:The generation and maintenance of B lymphocytes is controlled by biochemical signals transmitted by the B cell antigen receptor(BCR) complex. These signals are transduced by multiple cytoplasmic protein tyrosine kinases (PTKs) including Lyn, Syk, and Bruton's tyrosine kinase (BTK). Upon BCR engagement, these PTKs acti...

journal_title：Immunologic research

authors： Khan WN

更新日期：2001-01-01 00:00:00

abstract：:Anti-HMGCR antibodies represent a characteristic serological feature of statin-exposed and statin-unexposed patients with immune-mediated necrotizing myopathy (IMNM). We assessed anti-HMGCR antibodies in patients with suspected IMNM following statin exposure and patients with other autoimmune rheumatic diseases. We ev...

journal_title：Immunologic research

authors： Shovman O,Gilburd B,Chayat C,Lazar AD,Amital H,Blank M,Bentow C,Mahler M,Shoenfeld Y

更新日期：2017-02-01 00:00:00

abstract：:Joint damage in rheumatoid arthritis (RA) is characterized by cartilage and bone loss resulting in pain, deformity, and loss of joint function. Anti-citrullinated protein antibody (ACPA) has been implicated in RA pathogenesis and predicts radiographical joint damage and clinical severity. Therefore, the purpose of thi...

journal_title：Immunologic research

authors： Dusad A,Duryee MJ,Shaw AT,Klassen LW,Anderson DR,Wang D,Ren K,Gravallese EM,O'Dell JR,Mikuls TR,Thiele GM

更新日期：2014-01-01 00:00:00

abstract：:Neutrophils are key effector cells of the innate immune system and are involved in the host defense against invading pathogens such as viruses. Recently, it was reported that HIV-1-neutrophil interaction triggers neutrophil activation and promotes expression of Toll-like receptors (TLRs). Here, we assessed the role of...

journal_title：Immunologic research

authors： Giraldo DM,Hernandez JC,Urcuqui-Inchima S

更新日期：2016-12-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is a chronic, progressive cholestatic liver disease, which is invariably fatal. Circumstantial and indirect evidence suggests that autoimmune mechanisms have a role in the pathogenesis of PBC. Antimitochondrial antibodies (AMA) are highly sensitive and specific markers that can predict ...

journal_title：Immunologic research

authors： Bar-Dayan Y,Gershwin ME,Levi Y,Amital H,Shoenfeld Y

更新日期：1998-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a ubiquitous human gamma-herpesvirus that establishes life-long latency and is associated with lymphoproliferative disorders and the development of several malignancies. EBV infection is frequently, but not always, associated with the development of a syndrome termed infectious mononucleosi...

journal_title：Immunologic research

authors： Flaño E,Woodland DL,Blackman MA

更新日期：2002-01-01 00:00:00

abstract：:Psoriasis is a common chronic T-cell-mediated autoimmune skin disease, and traditional immunotherapies for psoriasis have focused on the direct inhibition of T cells, which often causes toxicity and lacks long-term effectiveness. Safe and effective therapeutic strategies are strongly needed for psoriasis. In this stud...

journal_title：Immunologic research

authors： Yan HX,Li WW,Zhang Y,Wei XW,Fu LX,Shen GB,Yin T,Li XY,Shi HS,Wan Y,Zhang QY,Li J,Yang SY,Wei YQ

更新日期：2014-10-01 00:00:00

abstract：:Risk posed by microbial superantigens in triggering or exacerbating SLE in genetically predisposed individuals, thereby altering the response to its treatment strategies, has not been studied. Using streptococcal pyrogenic exotoxin A and staphylococcal enterotoxin B as prototype superantigens, we have demonstrated tha...

journal_title：Immunologic research

authors： Dar SA,Janahi EM,Haque S,Akhter N,Jawed A,Wahid M,Ramachandran VG,Bhattacharya SN,Banerjee BD,Das S

更新日期：2016-08-01 00:00:00

abstract：:Anti-double-stranded DNA (dsDNA) B cells persist even in nonautoimmune- prone animals. In this review, we summarize data regarding the activation potential of these cells. Provision of cognate CD4 T cell help to anti-dsDNA B cells in nonautoimmune mice not only drives their maturation and entry into the B cell follicl...

journal_title：Immunologic research

authors： Fields ML,Seo SJ,Nish SA,Tsai JH,Caton AJ,Erikson J

更新日期：2003-01-01 00:00:00

abstract：:Herpes simplex virus type 1 infection of the mouse eye results in an impressive inflammatory response culminating in the death of the animal or the establishment of a "latent" infection depending on a number of ill-defined variables that include components of the innate and adaptive immune system. The application of t...

journal_title：Immunologic research

authors： Wickham S,Ash J,Lane TE,Carr DJ

更新日期：2004-01-01 00:00:00

abstract：:Chronic inflammation mediated by microglial cells is the fundamental process contributing to the death of dopamine (DA)-producing neurons in the brain. Production of inflammatory products by these microglial cells characterizes the slow destructive process in Parkinson's disease (PD). The activation of microglial cell...

journal_title：Immunologic research

authors： Qian L,Flood PM

更新日期：2008-01-01 00:00:00

abstract：:The participation of inflammatory cells in atherosclerosis is a well-known process that involves numerous molecules including chemotactic cytokines (chemokines) for their entry into the vessel wall. Although the C-C chemokine monocyte chemoattractant protein-1 and its receptor, CCR2, have been implicated in atheroscle...

journal_title：Immunologic research

authors： Boisvert WA,Curtiss LK,Terkeltaub RA

更新日期：2000-01-01 00:00:00

abstract：:This review of the events leading to the New Era of Immunology focuses on the important leads provided by the Experiments of Nature. Not only did they provide the path that led to our present knowledge of the ontogeny of the immune system, but also to an entirely new perspective of lymphocytic malignancies. The power ...

journal_title：Immunologic research

authors： Peterson RD

更新日期：2007-01-01 00:00:00

abstract：:In the last 15 years, the estimated prevalence of autoimmune diseases increased from about 4 to 9.4%. Autoimmune co-morbidity (i.e., the association between two or more autoimmune diseases in the same patient) is present in 0.4-0.5% of the worldwide population, more frequently in patients with multiple sclerosis, rheu...

journal_title：Immunologic research

authors： Tozzoli R,Sorrentino MC,Bizzaro N

更新日期：2013-07-01 00:00:00

abstract：:The intestinal epithelium serves as one of human's primary interfaces with the outside world. This interface is very heavily colonized with bacteria and yet permits absorption of life-sustaining nutrients while protecting the tissues below from microbial onslaught. Although the gut epithelium had been classically thou...

journal_title：Immunologic research

authors： Yu Y,Sitaraman S,Gewirtz AT

更新日期：2004-01-01 00:00:00

abstract：:We have recently established new bone marrow transplantation (BMT) methods for the treatment of intractable diseases. The methods include the perfusion method (PM) for the collection of bone marrow cells, and intra-bone marrow (IBM)-BMT for the direct injection of collected whole bone marrow cells into the bone marrow...

journal_title：Immunologic research

authors： Ikehara S

更新日期：2007-01-01 00:00:00

abstract：:CD8+ T cells are critically important for immune defense against many viral and bacterial pathogens, and are also key components of cancer immunotherapy. Help from CD4+ T cells is usually essential for optimal CD8+ T cell responses, driving the primary response, the survival of memory cells, and the generation of prot...

journal_title：Immunologic research

authors： Livingstone AM,Wilson EB,Ontiveros F,Wang JC

更新日期：2009-12-01 00:00:00

abstract：:The coexistence of alopecia areata (AA) and systemic lupus erythematosus (SLE) has been described, but the association between these conditions is yet to be firmly established. We aimed to evaluate the association between AA and SLE using a large-scale real-life computerized database. A cross-sectional study was condu...

journal_title：Immunologic research

authors： Kridin K,Shalom G,Comaneshter D,Cohen AD

更新日期：2020-02-01 00:00:00

abstract：:Immunological memory is a hallmark of adaptive immunity, a defense mechanism endowed to vertebrates during evolution. However, an autoimmune pathogenic role of memory lymphocytes is also emerging with accumulating evidence, despite reasonable skepticism on their existence in a chronic setting of autoimmune damage. It ...

journal_title：Immunologic research

authors： Devarajan P,Chen Z

更新日期：2013-12-01 00:00:00

abstract：:Primate complement receptor type 1 (CR1) protein, a single-chain transmembrane glycoprotein, plays an important role in immune adherence and clearing complement-opsonized immune complexes. Here, the mRNA of the porcine primate-like complement receptor (CR1-like) gene was analyzed, and two domain sequences with potenti...

journal_title：Immunologic research

authors： Yin W,Wei X,Jiang J,Fan K,Zhao J,Sun N,Wang Z,Sun Y,Ma H,Zhao X,Li H

更新日期：2016-08-01 00:00:00

abstract：:Modulating PI3K at different stages of dendritic cells (DC) generation could be a novel means to balance the generation of immunosuppressive versus immunostimulatory DC. We show that PI3K inhibition during mouse DC generation in vitro results in cells that are potently immunosuppressive and characteristic of CD8alpha-...

journal_title：Immunologic research

authors： Di Caro V,D'Anneo A,Phillips B,Engman C,Harnaha J,Trucco M,Giannoukakis N

更新日期：2011-08-01 00:00:00

abstract：:This is a journey that began in medical school at Stanford in 1963 and that is still underway, now as faculty member here for the past 40 years. History is by its nature selective, and I chose highlights that reflect on the remarkable progress we have made using the immune system to treat cancer. We will never be sati...

journal_title：Immunologic research

authors： Levy R

更新日期：2014-05-01 00:00:00

abstract：:It is now apparent that naïve peripheral T cells are a dynamic population where active processes prevent inappropriate activation while supporting survival. The process of thymic education makes naïve peripheral T cells dependent on interactions with self-MHC for survival. However, as these signals can potentially res...

journal_title：Immunologic research

authors： Modiano JF,Johnson LD,Bellgrau D

更新日期：2008-01-01 00:00:00