Abstract：
:Primary biliary cirrhosis (PBC) is a chronic, progressive cholestatic liver disease, which is invariably fatal. Circumstantial and indirect evidence suggests that autoimmune mechanisms have a role in the pathogenesis of PBC. Antimitochondrial antibodies (AMA) are highly sensitive and specific markers that can predict the development of the disease in a healthy individual. Long-term administration of ursodeoxycholic acid (UDCA), a naturally occurring bile acid, safely slows the progression of PBC, delays the need for liver transplantation, and postpones death. An effort should be made to identify the patients with PBC in the asymptomatic stage by the presence of AMA and to conduct a clinical trial in order to assess the benefit of long-term administration of UDCA on the prevention of the overt disease in these individuals.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Bar-Dayan Y,Gershwin ME,Levi Y,Amital H,Shoenfeld Ydoi
10.1007/BF02788754subject
Has Abstractpub_date
1998-01-01 00:00:00pages
117-23issue
2eissn
0257-277Xissn
1559-0755journal_volume
18pub_type
杂志文章,评审abstract：:An effective host response against viral infection of the central nervous system (CNS) is the principal factor dictating the outcome of infection. It is the responsibility of the immune response to contain and control viral replication. Paradoxically, it is the immune response that may also contribute to the developme...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:24:2:111
更新日期：2001-01-01 00:00:00
abstract：:The aim of the present study was to examine the role and mechanism of interleukin-10 (IL-10)-producing regulatory B cells (B10 cells) in the pathogenesis of Henoch-Schönlein purpura nephritis (HSPN). We examined the percentage of B10 cells, CD19+CD24hiCD38hi B cells, CD19+CD24hiCD27+ B cells, Th17 cells, and T regulat...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8877-8
更新日期：2017-06-01 00:00:00
abstract：:Our laboratory has studied the role of CD40 ligand (CD40L, CD154) in the primate immune response to allogenic and infectious challenges. We find that intensive early blockade of CD40L reliably attenuates acute rejection of primate cardiac allografts. Monotherapy fails to prevent late graft loss, which often occurs in ...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1385/IR:23:2-3:253
更新日期：2001-01-01 00:00:00
abstract：:Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-016-8836-4
更新日期：2017-02-01 00:00:00
abstract：:Vaccination represents one of the most efficacious and cost-effective medical interventions. It is the only medical intervention proven to eliminate disease at a global level. Many of the pathogens against which we most require adequate vaccines infect via the highly exposed mucosal surfaces. For this reason the mucos...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:30:1:035
更新日期：2004-01-01 00:00:00
abstract：:Mouse mammary tumor virus (MMTV) is a nonacute transforming retrovirus that causes mammary tumors in susceptible strains of mice. Upon milk-borne transmission, B cells in the gut become infected and subsequently present a virus-encoded superantigen to cognate T cells. These T cells become activated and, in turn, stimu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:27:2-3:469
更新日期：2003-01-01 00:00:00
abstract：:Purified protein derivative (PPD) or tuberculin skin testing is used to identify infected individuals with Mycobacterium tuberculosis (Mtb) and to assess cell-mediated immunity to Mtb. In the present study, we compared PBMC cultures in the presence of tuberculin or Candida antigens using cytokine bead arrays and RNA m...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-008-8024-2
更新日期：2009-01-01 00:00:00
abstract：:Soybeans are rich in immuno-modulatory isoflavones such as genistein, daidzein, and glycitein. These isoflavones are well-known antioxidants, chemopreventive and anti-inflammatory agents. Several epidemiological studies suggest that consumption of traditional soy food containing isoflavones is associated with reduced ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8331-5
更新日期：2012-12-01 00:00:00
abstract：:B cell development starts in the bone marrow where hematopoietic stem cells (HSCs) progress through sequential developmental stages, as it differentiates into a naïve B cell expressing surface immunoglobulin. In the periphery, B cells that encounter antigen can further differentiate into antibody-secreting plasma cell...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-011-8225-y
更新日期：2011-08-01 00:00:00
abstract：:This is a journey that began in medical school at Stanford in 1963 and that is still underway, now as faculty member here for the past 40 years. History is by its nature selective, and I chose highlights that reflect on the remarkable progress we have made using the immune system to treat cancer. We will never be sati...
journal_title：Immunologic research
pub_type： 传,历史文章,杂志文章,评审
doi：10.1007/s12026-014-8506-3
更新日期：2014-05-01 00:00:00
abstract：:Assembly of the class I MHC molecule is inextricably linked to the antigen presentation function of the class I molecule. Association of the class I MHC molecule with beta 2-microglobulin (beta 2m) is a prerequisite for association with the heterodimeric protein TAP, and once peptide is acquired, the class I molecule ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918217
更新日期：1995-01-01 00:00:00
abstract：:The neonate has an increased susceptibility to infection, in part owing to an inability to produce antibody to thymus-independent antigens such as bacterial polysaccharides (PS). This poor response to PS antigens is likely owing to multiple factors. Neonatal B cells are of an immature phenotype, as evidenced by cell-s...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:31:1:25
更新日期：2005-01-01 00:00:00
abstract：:Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by repeated episodes of apnea and hypopnea during sleep. Continuous positive airway pressure (CPAP) is the most effective method for treating OSAS and alleviating the patients' symptoms. The aim of this study was to assess the effect of 3...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8869-8
更新日期：2016-12-01 00:00:00
abstract：:Modulating PI3K at different stages of dendritic cells (DC) generation could be a novel means to balance the generation of immunosuppressive versus immunostimulatory DC. We show that PI3K inhibition during mouse DC generation in vitro results in cells that are potently immunosuppressive and characteristic of CD8alpha-...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-011-8206-1
更新日期：2011-08-01 00:00:00
abstract：:Schizophrenia is considered to be of the severe psychiatric disorders characterized by chronic debilitating course marked with frequent relapses and high clinical and financial burden. Aberrations of thyroid hormone levels have been documented in several psychiatric conditions including bipolar disease. The aim of thi...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-9030-7
更新日期：2018-12-01 00:00:00
abstract：:Type I diabetes (T1D) is a chronic autoimmune disease caused by pancreatic β-cell destruction induced by autoantibodies and autoreactive T cells. After significant reduction of the β-cell mass, diabetes sets in and can cause significant complications. It is estimated that more than 3 million Americans have T1D, and it...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8546-8
更新日期：2014-08-01 00:00:00
abstract：:During thymocyte development bone marrow-derived precursors in the thymus undergo a series of differentiation steps to produce self-tolerant, mature T lymphocytes. The thymus contains two functionally distinct anatomical compartments, consisting of a centrally located medulla surrounded by the thymic cortex. These com...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8301-y
更新日期：2012-12-01 00:00:00
abstract：:Acute graft-versus-host disease (aGvHD) is still a major cause of transplant-related mortality after allogeneic stem cell transplantation (ASCT). It requires immunosuppressive treatments that broadly abrogate T cell responses including beneficial ones directed against tumor cells or infective pathogens. Polo-like kina...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8778-2
更新日期：2016-06-01 00:00:00
abstract：:The human thymus is required for establishment of a normal T cell repertoire in fetal development, as children born without a thymus (DiGeorge Syndrome) lack thymus-derived (T) and T cell immunity. While the function of the thymus in children for production of new T cells is clear, it has not been obvious that the adu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:22:2-3:253
更新日期：2000-01-01 00:00:00
abstract：:Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work wil...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-007-0017-z
更新日期：2007-01-01 00:00:00
abstract：:The Caenorhabditis elegans model can be used to study Candida albicans virulence and host immunity, as well as to identify plant-derived natural products to use against C. albicans. Thymol is a hydrophobic phenol compound from the aromatic plant thyme. In this study, the in vitro data demonstrated concentration-depend...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8785-y
更新日期：2016-08-01 00:00:00
abstract：:Dendritic cells (DC) are the sentinels of the immune system, linking innate with adaptive responses. The functional responses of DC are subject to complex regulation and serve as targets for pathogens. Ca2+-mediated signal transduction pathways serve a central regulatory role in DC responses to diverse antigens, inclu...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-007-0076-1
更新日期：2007-01-01 00:00:00
abstract：:Recent research on hematological malignancies has shown that malignant cells often co-opt physiological pathways to promote their growth and development. Bone marrow homeostasis requires a fine balance between cellular differentiation and self-renewal; cell survival and apoptosis; and cellular proliferation and senesc...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-010-8187-5
更新日期：2011-04-01 00:00:00
abstract：:Recent advances in molecular medicine have shown that soluble MHC-multimers can be valuable tools for both analysis and modulation of antigen-specific immune responses in vitro and in vivo. In this review, we describe the use of dimeric human and mouse major histocompatibility complexes, MHC-Ig, as part of an artifici...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8156-z
更新日期：2010-07-01 00:00:00
abstract：:Chronic inflammation mediated by microglial cells is the fundamental process contributing to the death of dopamine (DA)-producing neurons in the brain. Production of inflammatory products by these microglial cells characterizes the slow destructive process in Parkinson's disease (PD). The activation of microglial cell...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-008-8018-0
更新日期：2008-01-01 00:00:00
abstract：:Natural killer cells play a major role in innate immunity against tumor and virus-infected cells. NK cells express activating and inhibitory receptors to regulate their function. It has been established that modulation in the NK cell receptor profile results in altered function of NK cell against target cells. Here, w...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8982-3
更新日期：2018-02-01 00:00:00
abstract：:Dendritic cells (DCs) are known to play an important role in initiating and orchestrating antimicrobial immunity. Given the fact that candidiasis appears often in immunocompromised patients, it seems plausible that DCs hold the key to new antifungal strategies. One possibility to enhance the potency of DC-based immuno...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-014-8562-8
更新日期：2015-03-01 00:00:00
abstract：:Tumor necrosis factor (TNF) inhibitors have been found to exhibit certain efficacy in treating refractory Takayasu arteritis (TA) in clinic despite severe adverse effects. The aim of this study is to investigate a natural anti-TNF compound, curcumin, its function, and its potential as treatment against TA. In total, 2...
journal_title：Immunologic research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12026-017-8917-z
更新日期：2017-08-01 00:00:00
abstract：:Allergic asthma is a chronic disease of the lung characterized by underlying Th2- and IgE-mediated inflammation, structural alterations of the bronchial wall, and airway hyperresponsiveness. Initial allergic sensitization and later development of chronic disease are determined by close interactions between lung struct...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8296-4
更新日期：2012-09-01 00:00:00
abstract：:Allogeneic hematopoietic cell transplantation has developed into a most successful form of immunotherapy for hematologic malignancies in the past 50 years. However, its effectiveness and wider applications have been greatly limited by the development of graft-versus-host disease (GVHD), a potentially lethal side effec...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-010-8193-7
更新日期：2011-04-01 00:00:00
