Impact of lymphocyte apoptosis on the innate immune stages of infection.

Abstract:

:Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work will highlight some of our recent work on Listeria induced apoptosis and its immunological consequences. We show that Listeria produces a toxin, listeriolysin O (LLO), which causes apoptosis of lymphocytes in vitro and in vivo. Early during the infection, type I interferon sensitizes lymphocytes to die by LLO-induced apoptosis. The cell death peaks during the first two days of the infection, leading to the production of IL-10 and downregulation of anti-microbial activity in the spleen. The induction of apoptosis by Listeria creates an infective niche in the peri-arteriolar lymphoid sheaths of the spleen which allows the bacteria to grow exponentially.

journal_name

Immunol Res

journal_title

Immunologic research

authors

Carrero JA,Unanue ER

doi

10.1007/s12026-007-0017-z

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

333-41

issue

1-3

eissn

0257-277X

issn

1559-0755

pii

IR:38:1-3:333

journal_volume

38

pub_type

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