Abstract:
:Assembly of the class I MHC molecule is inextricably linked to the antigen presentation function of the class I molecule. Association of the class I MHC molecule with beta 2-microglobulin (beta 2m) is a prerequisite for association with the heterodimeric protein TAP, and once peptide is acquired, the class I molecule folds and begins its sojourn to the cell surface. To maintain its folded conformation, class I MHC requires peptide but not beta 2m, and the sequence of the peptide bound exercises a subtle influence on the structure of the class I molecule that is likely to be a factor in T cell receptor discrimination of MHC/peptide complexes.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Solheim JC,Cook JR,Hansen THdoi
10.1007/BF02918217subject
Has Abstractpub_date
1995-01-01 00:00:00pages
200-17issue
3eissn
0257-277Xissn
1559-0755journal_volume
14pub_type
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