Abstract:
:Heat shock proteins (HSPs) are evolutionarily highly conserved polypeptides synthesized by many cells to preserve cellular functions under a variety of stressful conditions including infections. We have investigated the involvement of 65-kDa HSP (HSP65) in host protection against an intracellular protozoan parasite, Toxoplasma gondii, in mice. Experiments using low and highly virulent strains of Tox. gondii revealed that induction of murine HSP65 on macrophages closely correlates with protection against infection with this protozoan. Furthermore, we clarified that T cells, especially gamma delta T cells, are indispensable for HSP65 expression. A similar relationship between the expression of HSP65 on host macrophages and protective immunity was observed in mice infected with Leishmania major and Trypanosoma cruzi, both of which are obligate intracellular protozoa as is Tox. gondii.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Himeno K,Hisaeda Hdoi
10.1007/BF02918253subject
Has Abstractpub_date
1996-01-01 00:00:00pages
258-64issue
3eissn
0257-277Xissn
1559-0755journal_volume
15pub_type
杂志文章,评审abstract::We examine whether B cell lines enriched for DNA specificity from either autoimmune (BWF1) or normal mice (Balb/c) can be rendered unresponsive to autoantigen in terms of the specific suppression of direct antibody-forming cells to DNA. These B cell lines were both Lyt-1 positive and negative. Preincubation with oligo...
journal_title:Immunologic research
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更新日期:1989-01-01 00:00:00
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journal_title:Immunologic research
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更新日期:2001-01-01 00:00:00
abstract::Previous studies by our group, using an experimental autoimmune thyroiditis (EAT) model in Strain 13 inbred guinea pigs, resulted in T cell-mediated delayed hypersensitivity; however, autoantibodies proved not to be cytotoxic to thyroid epithelial cells in the presence or absence of complement proteins. Albeit, T cell...
journal_title:Immunologic research
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更新日期:2011-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s12026-017-8900-8
更新日期:2017-06-01 00:00:00
abstract::The etiology of polyarteritis nodosa (PAN) and localized PAN, including cutaneous arteritis (CA), remains unknown; however, initial endothelial damage has been implicated. The intima of the vasculitis lesions is predominantly infiltrated by innate-like bystander-activated CD8 T cells, in addition to the macrophages. M...
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pub_type: 杂志文章
doi:10.1007/s12026-020-09140-w
更新日期:2020-06-01 00:00:00
abstract::Type I diabetes (T1D) is a chronic autoimmune disease caused by pancreatic β-cell destruction induced by autoantibodies and autoreactive T cells. After significant reduction of the β-cell mass, diabetes sets in and can cause significant complications. It is estimated that more than 3 million Americans have T1D, and it...
journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12026-017-8917-z
更新日期:2017-08-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-013-8456-1
更新日期:2013-12-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8715-4
更新日期:2016-04-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-016-8876-9
更新日期:2016-12-01 00:00:00
abstract::Schizophrenia is considered to be of the severe psychiatric disorders characterized by chronic debilitating course marked with frequent relapses and high clinical and financial burden. Aberrations of thyroid hormone levels have been documented in several psychiatric conditions including bipolar disease. The aim of thi...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-018-9030-7
更新日期:2018-12-01 00:00:00
abstract::Risk posed by microbial superantigens in triggering or exacerbating SLE in genetically predisposed individuals, thereby altering the response to its treatment strategies, has not been studied. Using streptococcal pyrogenic exotoxin A and staphylococcal enterotoxin B as prototype superantigens, we have demonstrated tha...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8768-4
更新日期:2016-08-01 00:00:00
abstract::The generation and maintenance of B lymphocytes is controlled by biochemical signals transmitted by the B cell antigen receptor(BCR) complex. These signals are transduced by multiple cytoplasmic protein tyrosine kinases (PTKs) including Lyn, Syk, and Bruton's tyrosine kinase (BTK). Upon BCR engagement, these PTKs acti...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:23:2-3:147
更新日期:2001-01-01 00:00:00
abstract::During thymocyte development bone marrow-derived precursors in the thymus undergo a series of differentiation steps to produce self-tolerant, mature T lymphocytes. The thymus contains two functionally distinct anatomical compartments, consisting of a centrally located medulla surrounded by the thymic cortex. These com...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-012-8301-y
更新日期:2012-12-01 00:00:00
abstract::Chronic infections have been a major topic of investigation in recent years, but the mechanisms that dictate whether or not a pathogen is successfully controlled are incompletely understood. Cytomegalovirus (CMV) is a herpesvirus that establishes a persistent infection in the majority of people in the world. Like othe...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-011-8251-9
更新日期:2011-12-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-008-8084-3
更新日期:2009-01-01 00:00:00
abstract::The key role of T cells in hepatitis C virus (HCV) elimination and the ability of dendritic cells (DCs) to induce antiviral T cell responses suggest that DC vaccines could be a promising approach in the treatment of chronic HCV infection. The aim of our study was to evaluate, whether immunotherapy with DCs is safe and...
journal_title:Immunologic research
pub_type: 临床试验,杂志文章
doi:10.1007/s12026-017-8967-2
更新日期:2018-02-01 00:00:00
abstract::In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe h...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-019-9066-3
更新日期:2019-02-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
abstract::Class II MHC molecules present processed peptides from exogenous antigens to CD4+ helper T lymphocytes. In so doing, they are central to immunity, driving both the humoral and cell mediated arms of the immune response. Class II MHC molecules, and the genes encoding them, are expressed primarily in cells of the immune ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:27:1:85
更新日期:2003-01-01 00:00:00
abstract::Pathologies attributable to fungal infections represent a growing concern in both developed and developing countries. Initially discovered as opportunistic pathogens of immunocompromised hosts, fungi such as Candida albicans are now being placed at the centre of a more complex and dynamic picture in which the outcome ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-012-8265-y
更新日期:2012-09-01 00:00:00
abstract::Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE ...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-010-8175-9
更新日期:2011-04-01 00:00:00
abstract::A 20-year-old man developed severe abdominal pain 1 week after being vaccinated with the first dose of quadrivalent human papillomavirus (HPV) vaccine (Gardasil®). Despite ongoing symptoms of nausea and pain, he received the second dose of the vaccine. Only 10 days later, laboratory results revealed significantly elev...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-016-8823-9
更新日期:2017-02-01 00:00:00
abstract::In performing host-defense functions, cells of the immune system become activated by soluble chemokine signals and must migrate through endothelial cell or solid tissue barriers to reach sites of inflammation or infection. Regulated adhesive interactions of immune cells with endothelium, extracellular matrix component...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:21:2-3:293
更新日期:2000-01-01 00:00:00
abstract::Previous studies showed that interleukin (IL)-28B gene polymorphisms were associated with hepatitis C Virus (HCV) infection and treatment outcomes. We tested whether single-nucleotide polymorphisms (SNPs) in IL-28A and IL-28B are associated with HCV infection among Egyptians with HCV genotype 4 infections. We enrolled...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-018-9035-2
更新日期:2019-02-01 00:00:00
abstract::With several different CAR T cell therapies under advanced phases of clinical trials, and the first FDA-approved CAR treatments in 2017 (Yescarta and Kymriah), CAR T cell therapy has become one of the most promising therapies for the treatment of certain types of cancer. This success has bred an opportunity to optimiz...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-020-09119-7
更新日期:2020-02-01 00:00:00
abstract::Aberrant T helper-2 (Th2) responses play a critical role in the pathogenesis of allergic diseases. The underlying mechanism is to be further investigated. It is reported that soluble CD83 (sCD83) has immune-regulatory effects. This study aims to investigate the role of sCD83 in the regulation of Th2 polarization. Bloo...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-020-09133-9
更新日期:2020-06-01 00:00:00
abstract::The development and increasing diffusion of new vaccinations and global immunization protocols have aroused burning debates about safety of adjuvants and their immunogenicity-enhancing effect in vaccines. Shoenfeld and Agmon-Levin have grouped under the term "autoimmune/inflammatory syndrome induced by adjuvants" (ASI...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8586-0
更新日期:2014-12-01 00:00:00
abstract::Human α-fucosidase (EC 3.2.1.51) is an enzyme (hydrolase) of particular biological and medical interest, as the inherited deficiency in its activity leads to fucosidosis, a pathology belonging to severe glycoprotein lysosomal storage disorders. Although its importance has increased in latest years, data about its plas...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-017-8943-x
更新日期:2017-10-01 00:00:00
abstract::For the last decade, we have focused on guanylyl cyclase C (GUCY2C) as a potentially ideal target antigen for colorectal cancer immunotherapy. GUCY2C is expressed only in intestinal epithelial cells and by nearly 100% of colorectal cancers. We have developed and tested a recombinant adenoviral vector possessing GUCY2C...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-011-8253-7
更新日期:2011-12-01 00:00:00