Abstract:
:In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe how mechanical/magnetic, genetic, or pharmacologic interference with the actin cytoskeleton enforces changes in cell shape and function and how such techniques can be used to control the phenotype and functions of immune cells such as macrophages and to develop novel anti-cancer and anti-rejection clinical therapies.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Wosik J,Suarez-Villagran M,Miller JH Jr,Ghobrial RM,Kloc Mdoi
10.1007/s12026-019-9066-3subject
Has Abstractpub_date
2019-02-01 00:00:00pages
1-11issue
1eissn
0257-277Xissn
1559-0755pii
10.1007/s12026-019-9066-3journal_volume
67pub_type
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