Abstract:
:Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well as prime disparate T-cell helper responses. Yet, there is increasing evidence that pDCs are a distinct cell type in the innate immune system. This review highlights aspects in which pDCs are unique in comparison to other antigen-presenting cells in regulating innate and adaptive immune responses.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Barchet W,Blasius A,Cella M,Colonna Mdoi
10.1385/IR:32:1-3:075subject
Has Abstractpub_date
2005-01-01 00:00:00pages
75-83issue
1-3eissn
0257-277Xissn
1559-0755pii
IR:32:1-3:075journal_volume
32pub_type
杂志文章,评审abstract::The complement system is well represented in the central nervous system. Glial cells and neurons produce or express all of the activation and regulatory proteins and the C3a/C5a receptors. Inhibition of complement activation is protective in experimental allergic encephalomyelitis, the animal model for multiple sclero...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:26:1-3:007
更新日期:2002-01-01 00:00:00
abstract::CD6 is a cell surface receptor expressed on the majority of T cells and a subset of B cells. When expressed, CD6 contributes to lymphocyte activation through its extracellular domain 1, while adhesion and cellular migration are related to the extracellular scavenger receptor cysteine-rich domain (SRCR-D)-3 of CD6. Ito...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-013-8423-x
更新日期:2013-07-01 00:00:00
abstract::Dendritic cells (DCs) are known to play an important role in initiating and orchestrating antimicrobial immunity. Given the fact that candidiasis appears often in immunocompromised patients, it seems plausible that DCs hold the key to new antifungal strategies. One possibility to enhance the potency of DC-based immuno...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-014-8562-8
更新日期:2015-03-01 00:00:00
abstract::We report on 12 patients with chronic granulomatous disease transplanted with hematopoietic stem cells from matched unrelated (n = 9) or matched sibling donors (n = 3). The most common infectious complication was pulmonary aspergillosis, which nine patients had previously developed. Only 5 of 12 individuals had normal...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-008-8068-3
更新日期:2009-01-01 00:00:00
abstract::WASP, the product of the gene mutated in Wiskott-Aldrich syndrome, is expressed only in hematopoietic cells and is the archetype of a family of proteins that include N-WASP and Scar/WAVE. WASP plays a critical role in T cell activation and actin reorganization. WASP has multiple protein-interacting domains. Through it...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-008-8086-1
更新日期:2009-01-01 00:00:00
abstract::Class II MHC molecules present processed peptides from exogenous antigens to CD4+ helper T lymphocytes. In so doing, they are central to immunity, driving both the humoral and cell mediated arms of the immune response. Class II MHC molecules, and the genes encoding them, are expressed primarily in cells of the immune ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:27:1:85
更新日期:2003-01-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-008-8056-7
更新日期:2009-01-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-010-8175-9
更新日期:2011-04-01 00:00:00
abstract::We retrospectively analyzed the transplantation outcomes of 31 patients with primary immunodeficiency diseases treated at our center (All Children's Hospital, University of South Florida) since its inception in 1986. The primary immune diseases included severe combined immunodeficiency, Wiscott-Aldrich syndrome, X-lin...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-009-8111-z
更新日期:2009-01-01 00:00:00
abstract::A complex interplay between pathogen and host determines the immune response during viral infection. A set of cytosolic sensors are expressed by immune cells to detect viral infection. NOD-like receptors (NLRs) comprise a large family of intracellular pattern recognition receptors. Members of the NLR family assemble i...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-016-8873-z
更新日期:2016-12-01 00:00:00
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journal_title:Immunologic research
pub_type: 传,历史文章,杂志文章,评审
doi:10.1007/s12026-014-8506-3
更新日期:2014-05-01 00:00:00
abstract::Chronic inflammation mediated by microglial cells is the fundamental process contributing to the death of dopamine (DA)-producing neurons in the brain. Production of inflammatory products by these microglial cells characterizes the slow destructive process in Parkinson's disease (PD). The activation of microglial cell...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-008-8018-0
更新日期:2008-01-01 00:00:00
abstract::Invariant CD1d-restricted natural killer T (iNKT) cells function during innate and adaptive immune responses. A functional and numerical deficiency of iNKT cells is well documented in both nonobese diabetic (NOD) mice and humans with autoimmune type 1 diabetes (T1D). Restoring the numerical and/or functional deficienc...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:31:3:177
更新日期:2005-01-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-018-8996-5
更新日期:2018-06-01 00:00:00
abstract::Consideration of the pathophysiology of insulin-dependent diabetes mellitus in the nonobese diabetic (NOD) mouse can be viewed from a temporal perspective. We argue that there are discontinuous phases and each phase may reflect a phenotype educed by a particular set of genetic and epigenetic events. Therefore, tempora...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786358
更新日期:1997-01-01 00:00:00
abstract::Corn, soybean, spinach leaf, and tomato aquaporins have been shown to share homology with human aquaporin-4, which is abundantly expressed by brain astrocytic endfeet. Thus, antibodies formed against the dietary aquaporins may potentially cross-react with brain aquaporin, leading to blood-brain barrier permeability an...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-018-9046-z
更新日期:2019-02-01 00:00:00
abstract::About one half of circulating human B cells express the Leu-8 peripheral lymph node homing receptor that has been implicated in adhesion of lymphocytes and neutrophils to vascular endothelium. A novel and unique function of the Leu-8 antigen has been found in the present study: anti-Leu-8 monoclonal antibody directly ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02919739
更新日期:1991-01-01 00:00:00
abstract::Acute graft-versus-host disease (aGvHD) is still a major cause of transplant-related mortality after allogeneic stem cell transplantation (ASCT). It requires immunosuppressive treatments that broadly abrogate T cell responses including beneficial ones directed against tumor cells or infective pathogens. Polo-like kina...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8778-2
更新日期:2016-06-01 00:00:00
abstract::Besides their well-characterized role as the initiator of adaptive immune responses, dendritic cells (DCs) play a critical role in the induction and maintenance of self-tolerance, the failure of which could lead to autoimmune/inflammatory diseases. Although it is clear that tolerance is a property of DCs at the steady...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-009-8126-5
更新日期:2010-03-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-012-8280-z
更新日期:2012-04-01 00:00:00
abstract::We have used MAb to L3T4 to examine the function of L3T4+ T cells in normal and autoimmune mice. Treatment of mice with MAb to L3T4 profoundly depleted L3T4+ cells from the blood, spleen, and lymph nodes, but not the thymus. In BALB/c and C57BL/6 mice, selective depletion of L3T4+ cells blocked both primary and second...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/BF02917584
更新日期:1986-01-01 00:00:00
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journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:33:2:135
更新日期:2005-01-01 00:00:00
abstract::The intestinal epithelium serves as one of human's primary interfaces with the outside world. This interface is very heavily colonized with bacteria and yet permits absorption of life-sustaining nutrients while protecting the tissues below from microbial onslaught. Although the gut epithelium had been classically thou...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:29:1-3:055
更新日期:2004-01-01 00:00:00
abstract::The attributes of specificity and memory enable CD8(+) T cells to provide long-lasting protection against a variety of challenges. Although, the importance of CD8(+) T cells for protection against intracellular infections and transformation is well-established, the functional type; effector phenotypes (Tc1, Tc2, Tc17 ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-009-8130-9
更新日期:2010-03-01 00:00:00
abstract::We have focused our research on understanding the basic biology of and developing novel therapeutic and prophylactic DNA vaccines. We have among others three distinct primary areas of interest which include: 1. Enhancing in vivo delivery and transfection of DNA vaccine vectors 2. Improving DNA vaccine construct immuno...
journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
abstract::Aberrant T helper-2 (Th2) responses play a critical role in the pathogenesis of allergic diseases. The underlying mechanism is to be further investigated. It is reported that soluble CD83 (sCD83) has immune-regulatory effects. This study aims to investigate the role of sCD83 in the regulation of Th2 polarization. Bloo...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-020-09133-9
更新日期:2020-06-01 00:00:00
abstract::An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is not well understood...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-010-8164-z
更新日期:2010-12-01 00:00:00
abstract::The key role of T cells in hepatitis C virus (HCV) elimination and the ability of dendritic cells (DCs) to induce antiviral T cell responses suggest that DC vaccines could be a promising approach in the treatment of chronic HCV infection. The aim of our study was to evaluate, whether immunotherapy with DCs is safe and...
journal_title:Immunologic research
pub_type: 临床试验,杂志文章
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更新日期:2018-02-01 00:00:00
abstract::With several different CAR T cell therapies under advanced phases of clinical trials, and the first FDA-approved CAR treatments in 2017 (Yescarta and Kymriah), CAR T cell therapy has become one of the most promising therapies for the treatment of certain types of cancer. This success has bred an opportunity to optimiz...
journal_title:Immunologic research
pub_type: 杂志文章,评审
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更新日期:2020-02-01 00:00:00
abstract::Genes of the major histocompatibility complex (MHC) are one of the most significant genetic predictors of HIV and SIV disease outcome; however, in no case is MHC genotype alone sufficient to account for this durable HIV/SIV control. Killer immunoglobulin-like receptors (KIRs) interact with MHC molecules and have been ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-007-8010-0
更新日期:2008-01-01 00:00:00