The many sounds of T lymphocyte silence.

Abstract:

:It is not unusual for antigens and potentially responsive T cells to co-exist in the same organism while these T cells remain silent and do not mount life-threatening immune responses. A rich array of mechanisms has been proposed to explain these observations. T cell silencing is controlled in multiple levels. Initially, dendritic cells and regulatory T cells appear to play critical roles. In addition, T cell immunity is tightly regulated by a molecular network of cytokines and cell receptor interactions by the opposed surfaces of antigen-presenting cells and T cells. Recognition of a specific antigen is therefore shaped and tuned by co-stimulatory and co-inhibitory receptor-ligand pairs. At last, immunologists are beginning to exploit the rules governing these assorted sounds of T cell silence.

journal_name

Immunol Res

journal_title

Immunologic research

authors

Melero I,Arina A,Chen L

doi

10.1385/IR:33:2:135

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

135-47

issue

2

eissn

0257-277X

issn

1559-0755

pii

IR:33:2:135

journal_volume

33

pub_type

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