Abstract:
:It is not unusual for antigens and potentially responsive T cells to co-exist in the same organism while these T cells remain silent and do not mount life-threatening immune responses. A rich array of mechanisms has been proposed to explain these observations. T cell silencing is controlled in multiple levels. Initially, dendritic cells and regulatory T cells appear to play critical roles. In addition, T cell immunity is tightly regulated by a molecular network of cytokines and cell receptor interactions by the opposed surfaces of antigen-presenting cells and T cells. Recognition of a specific antigen is therefore shaped and tuned by co-stimulatory and co-inhibitory receptor-ligand pairs. At last, immunologists are beginning to exploit the rules governing these assorted sounds of T cell silence.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Melero I,Arina A,Chen Ldoi
10.1385/IR:33:2:135subject
Has Abstractpub_date
2005-01-01 00:00:00pages
135-47issue
2eissn
0257-277Xissn
1559-0755pii
IR:33:2:135journal_volume
33pub_type
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