当前位置： SCI文献检索 > IMMUNOLOGIC RESEARCH期刊下所有文献 > Interleukin 28A.rs12980602 and interleukin 28B.rs8103142 genotypes could be protective against HCV infection among Egyptians.

Interleukin 28A.rs12980602 and interleukin 28B.rs8103142 genotypes could be protective against HCV infection among Egyptians.

Abstract：

:Previous studies showed that interleukin (IL)-28B gene polymorphisms were associated with hepatitis C Virus (HCV) infection and treatment outcomes. We tested whether single-nucleotide polymorphisms (SNPs) in IL-28A and IL-28B are associated with HCV infection among Egyptians with HCV genotype 4 infections. We enrolled 144 chronic HCV patients, 72 spontaneously resolved HCV subjects, and 69 healthy controls. Four SNPs in IL-28A and IL-28B genes (IL-28A.rs12980602, IL-28B.rs12979860, IL-28B.rs8099917, and IL-28B.rs8103142) were genotyped. The most frequent IL-28B haplotype "TCT" was significantly more frequent in HCV-infected subjects than in HCV negative subjects (62.2% vs. 48.6%, respectively; p = 0.005). The frequency of IL-28A.rs12980602 "T" allele was significantly higher than the "C" allele in healthy controls compared to HCV-infected subjects (p < 0.001) with the "TT" genotype significantly higher in healthy controls compared to HCV-infected subjects (p < 0.001) with no association with viral load (p = 0.11) among chronically infected subjects. The results, also, confirmed the previous role of IL-28B SNPs in predicting HCV infection outcome. Importantly, IL-28B.rs8099917 "TT" genotype was significantly associated with low viral load in HCV-infected subjects, while the remaining three SNPs did not. The three IL-28B SNPs were in linkage disequilibrium (D' > 0.68; r2 > 0.43) for all comparisons in HCV patients, while there was no linkage disequilibrium of IL-28A polymorphisms and the three IL-28B SNPs. In conclusion, IL-28A.rs12980602 and IL-28B.rs8103142 TT genotype could be protective against HCV infection. Also, IL-28B.rs12979860, IL-28B.rs8099917, and IL-28B.rs8103142 SNPs predicted the outcome of HCV infection among genotype-4-infected Egyptians. Moreover, IL-28B.rs8099917 SNP affected the viral load in chronic HCV patients.

journal_name

Immunol Res

journal_title

Immunologic research

authors

Zakaria ZA,Knapp S,Hashem M,Zaghla H,Thursz M,Waked I,Abdelwahab S

doi

10.1007/s12026-018-9035-2

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

123-133

issue

1

eissn

0257-277X

issn

1559-0755

pii

10.1007/s12026-018-9035-2

journal_volume

67

pub_type

杂志文章

相关文献

IMMUNOLOGIC RESEARCH文献大全
  • Genetic and biochemical regulation of CD4 T cell effector differentiation: insights from examination of T cell clonal anergy.

    abstract：:The two-signal model of T cell activation states that antigen recognition by TCR provides a tolerogenic signal (termed Signal 1) unless the T cell receives simultaneous costimulation (Signal 2) that permits antigen recognition to prime activation. Our efforts to characterize genetic and biochemical factors resulting f...

    journal_title：Immunologic research

    pub_type： 杂志文章,评审

    doi：10.1007/s12026-009-8147-0

    authors： Gamper CJ,Powell JD

    更新日期：2010-07-01 00:00:00

  • Anti-HMGCR antibodies demonstrate high diagnostic value in the diagnosis of immune-mediated necrotizing myopathy following statin exposure.

    abstract：:Anti-HMGCR antibodies represent a characteristic serological feature of statin-exposed and statin-unexposed patients with immune-mediated necrotizing myopathy (IMNM). We assessed anti-HMGCR antibodies in patients with suspected IMNM following statin exposure and patients with other autoimmune rheumatic diseases. We ev...

    journal_title：Immunologic research

    pub_type： 杂志文章

    doi：10.1007/s12026-016-8867-x

    authors： Shovman O,Gilburd B,Chayat C,Lazar AD,Amital H,Blank M,Bentow C,Mahler M,Shoenfeld Y

    更新日期：2017-02-01 00:00:00

  • Interleukin-8 and its receptor CXCR2 in atherosclerosis.

    abstract：:The participation of inflammatory cells in atherosclerosis is a well-known process that involves numerous molecules including chemotactic cytokines (chemokines) for their entry into the vessel wall. Although the C-C chemokine monocyte chemoattractant protein-1 and its receptor, CCR2, have been implicated in atheroscle...

    journal_title：Immunologic research

    pub_type： 杂志文章,评审

    doi：10.1385/ir:21:2-3:129

    authors： Boisvert WA,Curtiss LK,Terkeltaub RA

    更新日期：2000-01-01 00:00:00

  • Oxidases and oxygenases in regulation of vascular nitric oxide signaling and inflammatory responses.

    abstract：:Nitric oxide (.NO) is a freely diffusible inter- and intracellular messenger produced by a variety of mammalian cells including vascular endothelium, neurons, smooth muscle cells, macrophages, neutrophils, platelets, and pulmonary epithelium. In smooth muscle cells, platelets, and neutrophils, .NO raises intracellular...

    journal_title：Immunologic research

    pub_type： 杂志文章,评审

    doi：10.1385/IR:26:1-3:107

    authors： Aslan M,Freeman BA

    更新日期：2002-01-01 00:00:00

  • Fate vs choice: the immune system reloaded.

    abstract：:Development can occur by either instructive or stochastic processes. My colleagues and I have studied the contributions of these processes to differentiation of naïve CD4+ T-cells to either a Th1 or Th2 phenotype. Our initial discovery that pathogens in our in vitro priming system led to the development of Th1 cells t...

    journal_title：Immunologic research

    pub_type： 历史文章,杂志文章,评审

    doi：10.1385/IR:32:1-3:193

    authors： Murphy KM

    更新日期：2005-01-01 00:00:00

  • T follicular regulatory cells infiltrate the human airways during the onset of acute respiratory distress syndrome and regulate the development of B regulatory cells.

    abstract：:T follicular regulatory (Tfr) cell is a CXCR5+Foxp3+ subset of T regulatory (Treg) cell with critical roles in regulating germinal center responses and modulating the immune environment in the lymph nodes. Studies have shown that the proportion of Tfr cells may increase during acute inflammation. In this study, we inv...

    journal_title：Immunologic research

    pub_type： 杂志文章

    doi：10.1007/s12026-018-9014-7

    authors： Li H,Zhou R,Wang C,Li Y,Zheng G,Jiang S,Dong T,Bai J,Xu S

    更新日期：2018-08-01 00:00:00

  • Elevated follicular helper T cells and expression of IL-21 in thyroid tissues are involved in the pathogenesis of Graves' disease.

    abstract：:The follicular helper T cell (Tfh) and IL-21 have been shown to play an important role in many autoimmune diseases. However, less is known about their role in Graves' disease (GD). This study aimed to investigate the expression of Tfhs and related factors (IL-21, IL-21R, CXCR5, and CXCL13) in GD thyroid tissues and to...

    journal_title：Immunologic research

    pub_type： 杂志文章

    doi：10.1007/s12026-015-8647-z

    authors： Zhang J,Ren M,Zeng H,Guo Y,Zhuang Z,Feng Z,Yan H,Xu M,Liang W,Yang C,Cheng H,Ding H,Yan L

    更新日期：2015-06-01 00:00:00

  • Temporal discontinuities in progression of NOD autoimmune diabetes.

    abstract：:Consideration of the pathophysiology of insulin-dependent diabetes mellitus in the nonobese diabetic (NOD) mouse can be viewed from a temporal perspective. We argue that there are discontinuous phases and each phase may reflect a phenotype educed by a particular set of genetic and epigenetic events. Therefore, tempora...

    journal_title：Immunologic research

    pub_type： 杂志文章,评审

    doi：10.1007/BF02786358

    authors： Rudy GB,Sutherland RM,Lew AM

    更新日期：1997-01-01 00:00:00

  • Induction of bone loss in DBA/1J mice immunized with citrullinated autologous mouse type II collagen in the absence of adjuvant.

    abstract：:Joint damage in rheumatoid arthritis (RA) is characterized by cartilage and bone loss resulting in pain, deformity, and loss of joint function. Anti-citrullinated protein antibody (ACPA) has been implicated in RA pathogenesis and predicts radiographical joint damage and clinical severity. Therefore, the purpose of thi...

    journal_title：Immunologic research

    pub_type： 杂志文章

    doi：10.1007/s12026-013-8479-7

    authors： Dusad A,Duryee MJ,Shaw AT,Klassen LW,Anderson DR,Wang D,Ren K,Gravallese EM,O'Dell JR,Mikuls TR,Thiele GM

    更新日期：2014-01-01 00:00:00

  • Autoimmune/inflammatory syndrome induced by adjuvants-ASIA-related to biomaterials: analysis of 45 cases and comprehensive review of the literature.

    abstract：:Systemic autoimmune or granulomatous disorders related to biomaterials of human use have rarely been described. The aim of this study was to report cases of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) related to biomaterial injections and prostheses, mainly silicone, hyaluronic acid, acrylamides and m...

    journal_title：Immunologic research

    pub_type： 杂志文章

    doi：10.1007/s12026-017-8980-5

    authors： Alijotas-Reig J,Esteve-Valverde E,Gil-Aliberas N,Garcia-Gimenez V

    更新日期：2018-02-01 00:00:00

  • Potential regulatory role of in vitro-expanded Vδ1 T cells from human peripheral blood.

    abstract：:γδ T cells represent a relevant proportion of T lymphocytes that express T cell receptors (TCRs) encoded by the γ and δ T cell receptor genes. Whereas the most circulating γδ T cell type, Vδ2 T cells, has been described and studied intensively, the potential role of Vδ1 T cells remains largely unclear. Here, we identi...

    journal_title：Immunologic research

    pub_type： 杂志文章

    doi：10.1007/s12026-013-8390-2

    authors： Hua F,Kang N,Gao YA,Cui LX,Ba DN,He W

    更新日期：2013-05-01 00:00:00

  • Mucosal immunity: overcoming the barrier for induction of proximal responses.

    abstract：:Vaccination represents one of the most efficacious and cost-effective medical interventions. It is the only medical intervention proven to eliminate disease at a global level. Many of the pathogens against which we most require adequate vaccines infect via the highly exposed mucosal surfaces. For this reason the mucos...

    journal_title：Immunologic research

    pub_type： 杂志文章,评审

    doi：10.1385/IR:30:1:035

    authors： McKenzie BS,Brady JL,Lew AM

    更新日期：2004-01-01 00:00:00

  • Analysis of the function of L3T4+ T cells by in vivo treatment with monoclonal antibody to L3T4.

    abstract：:We have used MAb to L3T4 to examine the function of L3T4+ T cells in normal and autoimmune mice. Treatment of mice with MAb to L3T4 profoundly depleted L3T4+ cells from the blood, spleen, and lymph nodes, but not the thymus. In BALB/c and C57BL/6 mice, selective depletion of L3T4+ cells blocked both primary and second...

    journal_title：Immunologic research

    pub_type： 杂志文章

    doi：10.1007/BF02917584

    authors： Wofsy D,Seaman WE

    更新日期：1986-01-01 00:00:00

  • Consequences of CXCL10 and IL-6 induction by the murine IFN-alpha1 transgene in ocular herpes simplex virus type 1 infection.

    abstract：:Herpes simplex virus type 1 infection of the mouse eye results in an impressive inflammatory response culminating in the death of the animal or the establishment of a "latent" infection depending on a number of ill-defined variables that include components of the innate and adaptive immune system. The application of t...

    journal_title：Immunologic research

    pub_type： 杂志文章

    doi：10.1385/IR:30:2:191

    authors： Wickham S,Ash J,Lane TE,Carr DJ

    更新日期：2004-01-01 00:00:00

  • Immunotherapy with interferon-α-induced dendritic cells for chronic HCV infection (the results of pilot clinical trial).

    abstract：:The key role of T cells in hepatitis C virus (HCV) elimination and the ability of dendritic cells (DCs) to induce antiviral T cell responses suggest that DC vaccines could be a promising approach in the treatment of chronic HCV infection. The aim of our study was to evaluate, whether immunotherapy with DCs is safe and...

    journal_title：Immunologic research

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12026-017-8967-2

    authors： Chernykh E,Leplina O,Oleynik E,Tikhonova M,Tyrinova T,Starostina N,Ostanin A

    更新日期：2018-02-01 00:00:00

  • DNA vaccines: developing new strategies to enhance immune responses.

    abstract：:We have focused our research on understanding the basic biology of and developing novel therapeutic and prophylactic DNA vaccines. We have among others three distinct primary areas of interest which include: 1. Enhancing in vivo delivery and transfection of DNA vaccine vectors 2. Improving DNA vaccine construct immuno...

    journal_title：Immunologic research

    pub_type： 杂志文章,评审

    doi：10.1007/s12026-008-8076-3

    authors： Abdulhaqq SA,Weiner DB

    更新日期：2008-01-01 00:00:00

  • Generation of tolerogenic dendritic cells via the E-cadherin/beta-catenin-signaling pathway.

    abstract：:Besides their well-characterized role as the initiator of adaptive immune responses, dendritic cells (DCs) play a critical role in the induction and maintenance of self-tolerance, the failure of which could lead to autoimmune/inflammatory diseases. Although it is clear that tolerance is a property of DCs at the steady...

    journal_title：Immunologic research

    pub_type： 杂志文章,评审

    doi：10.1007/s12026-009-8126-5

    authors： Fu C,Jiang A

    更新日期：2010-03-01 00:00:00

  • The emerging field of osteoimmunology.

    abstract：:Recent studies have elucidated unanticipated connections between the immune and skeletal systems, and this relationship has led to the development of a new field known as osteoimmunology. The goal of research in this field is to: (1) further understand how the bone microenvironment influences immune cell ontogeny and ...

    journal_title：Immunologic research

    pub_type： 杂志文章,评审

    doi：10.1007/s12026-009-8093-x

    authors： Mensah KA,Li J,Schwarz EM

    更新日期：2009-12-01 00:00:00

  • Cross-linking the Leu-8 lymph node homing receptor on B cells inhibits immunoglobulin synthesis.

    abstract：:About one half of circulating human B cells express the Leu-8 peripheral lymph node homing receptor that has been implicated in adhesion of lymphocytes and neutrophils to vascular endothelium. A novel and unique function of the Leu-8 antigen has been found in the present study: anti-Leu-8 monoclonal antibody directly ...

    journal_title：Immunologic research

    pub_type： 杂志文章,评审

    doi：10.1007/BF02919739

    authors： Murakawa Y,Strober W,James SP

    更新日期：1991-01-01 00:00:00

  • ITIMs and ITAMs. The Yin and Yang of antigen and Fc receptor-linked signaling machinery.

    abstract：:The initial stages of an immune response are regulated at the level of the cell-surface antigen and Fc receptors. The extracellular portions of these receptors provide immune specificity and determine the nature of the responding effector cells, whereas the intracellular portion transduces signals into the cell and de...

    journal_title：Immunologic research

    pub_type： 杂志文章,评审

    doi：10.1007/BF02786325

    authors： Isakov N

    更新日期：1997-02-01 00:00:00

  • "Experiments of Nature" and the New Era of Immunology: an historical perspective.

    abstract：:This review of the events leading to the New Era of Immunology focuses on the important leads provided by the Experiments of Nature. Not only did they provide the path that led to our present knowledge of the ontogeny of the immune system, but also to an entirely new perspective of lymphocytic malignancies. The power ...

    journal_title：Immunologic research

    pub_type： 历史文章,杂志文章

    doi：10.1007/s12026-007-0047-6

    authors： Peterson RD

    更新日期：2007-01-01 00:00:00

  • Requirements for activation of CD8+ murine T cells. I. Development of cytolytic activity.

    abstract：:Cytolytic effector function fails to develop if proliferation of allospecific cytolytic T lymphocyte precursors is inhibited, but the requirements for generation of cytolytic activity have not been fully defined. In contrast, the cytolytic effector function of cytolytic T lymphocyte clones does not change during the c...

    journal_title：Immunologic research

    pub_type： 杂志文章

    doi：10.1007/BF02935614

    authors： Cronin DC 2nd,Lancki DW,Fitch FW

    更新日期：1994-01-01 00:00:00

  • Curcumin improves treatment outcome of Takayasu arteritis patients by reducing TNF-α: a randomized placebo-controlled double-blind clinical trial.

    abstract：:Tumor necrosis factor (TNF) inhibitors have been found to exhibit certain efficacy in treating refractory Takayasu arteritis (TA) in clinic despite severe adverse effects. The aim of this study is to investigate a natural anti-TNF compound, curcumin, its function, and its potential as treatment against TA. In total, 2...

    journal_title：Immunologic research

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s12026-017-8917-z

    authors： Shao N,Jia H,Li Y,Li J

    更新日期：2017-08-01 00:00:00

  • Linking complement and anti-dsDNA antibodies in the pathogenesis of systemic lupus erythematosus.

    abstract：:Systemic lupus erythematosus is a severe autoimmune disease that affects multiple organ systems resulting in diverse symptoms and outcomes. It is characterized by antibody production to a variety of self-antigens, but it is specifically associated with those against anti-dsDNA. Anti-dsDNA antibodies are present before...

    journal_title：Immunologic research

    pub_type： 杂志文章,评审

    doi：10.1007/s12026-012-8345-z

    authors： Giles BM,Boackle SA

    更新日期：2013-03-01 00:00:00

  • Effector functions of memory CTLs can be affected by signals received during reactivation.

    abstract：:Memory cytotoxic T lymphocytes (CTLs) are able to provide protections to the host against repeated insults from intracellular pathogens. However, it has not been completely understood how the effector functions of memory CTLs are induced upon antigen challenge, which is directly related to the efficacy of their protec...

    journal_title：Immunologic research

    pub_type： 杂志文章

    doi：10.1007/s12026-017-8920-4

    authors： Lv Y,Mattson E,Bhadurihauck A,Garcia K,Li L,Xiao Z

    更新日期：2017-08-01 00:00:00

  • Microbial/host interactions: mechanisms involved in host responses to microbial antigens.

    abstract：:The indigenous oral microflora and the host are normally in a state of equilibrium; however, the introduction of a pathogen can result in innate and adaptive immune responses that either contribute to the development of the disease or lead to host immunity. The interactions between the microorganisms and the host are ...

    journal_title：Immunologic research

    pub_type： 杂志文章,评审

    doi：10.1385/IR:26:1-3:223

    authors： Michalek SM,Katz J,Childers NK,Martin M,Balkovetz DF

    更新日期：2002-01-01 00:00:00

  • Presentation of cytosolic antigens via MHC class II molecules.

    abstract：:Major histocompatibility (MHC) class II molecules function to present antigenic peptides to CD4 T lymphocytes. The pathways by which these molecules present exogenous antigens have been extensively studied. However by contrast, far less is known about the processing and trafficking of cytosolic antigens, which can als...

    journal_title：Immunologic research

    pub_type： 杂志文章,评审

    doi：10.1385/IR:30:3:279

    authors： Zhou D,Blum JS

    更新日期：2004-01-01 00:00:00

  • Prevention of GVHD without losing GVL effect: windows of opportunity.

    abstract：:Allogeneic hematopoietic cell transplantation has developed into a most successful form of immunotherapy for hematologic malignancies in the past 50 years. However, its effectiveness and wider applications have been greatly limited by the development of graft-versus-host disease (GVHD), a potentially lethal side effec...

    journal_title：Immunologic research

    pub_type： 杂志文章,评审

    doi：10.1007/s12026-010-8193-7

    authors： Zhang P,Chen BJ,Chao NJ

    更新日期：2011-04-01 00:00:00

  • Complement receptor activity of recombinant porcine CR1-like protein expressed in a eukaryotic system.

    abstract：:Primate complement receptor type 1 (CR1) protein, a single-chain transmembrane glycoprotein, plays an important role in immune adherence and clearing complement-opsonized immune complexes. Here, the mRNA of the porcine primate-like complement receptor (CR1-like) gene was analyzed, and two domain sequences with potenti...

    journal_title：Immunologic research

    pub_type： 杂志文章

    doi：10.1007/s12026-016-8792-z

    authors： Yin W,Wei X,Jiang J,Fan K,Zhao J,Sun N,Wang Z,Sun Y,Ma H,Zhao X,Li H

    更新日期：2016-08-01 00:00:00

  • Plasma alpha-L-fucosidase activity in chronic inflammation and autoimmune disorders in a pediatric cohort of hospitalized patients.

    abstract：:Human α-fucosidase (EC 3.2.1.51) is an enzyme (hydrolase) of particular biological and medical interest, as the inherited deficiency in its activity leads to fucosidosis, a pathology belonging to severe glycoprotein lysosomal storage disorders. Although its importance has increased in latest years, data about its plas...

    journal_title：Immunologic research

    pub_type： 杂志文章

    doi：10.1007/s12026-017-8943-x

    authors： Endreffy I,Bjørklund G,Szerafin L,Chirumbolo S,Urbina MA,Endreffy E

    更新日期：2017-10-01 00:00:00