Abstract:
:Upon entry to the systemic circulation, neutrophils exhibit a short mean time to cell death. The viability of most cell types in a steady state is preserved by the interplay of the Bcl-2 family of proteins, wherein the anti-apoptotic members inhibit the action of their pro-apoptotic counterparts. Neutrophils, however, display absent or severely reduced expression of several anti-apoptotic Bcl-2 family proteins. Hence, they rely on the expression of Mcl-1, an anti-apoptotic member of the Bcl-2 family, for survival. This protein is uniquely short-lived relative to related proteins and its loss likely precipitates the induction of apoptosis in neutrophils. This review describes the role of Mcl-1 in the neutrophil in the context of apoptosis and highlights the proteins' importance to the cell. We also address neutrophil apoptosis in the broader context of the cells' response to pathogens, focussing particularly on the strategies used by pathogens to manipulate the apoptotic pathway to their own ends.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Murphy MP,Caraher Edoi
10.1007/s12026-015-8655-zsubject
Has Abstractpub_date
2015-06-01 00:00:00pages
225-33issue
2eissn
0257-277Xissn
1559-0755journal_volume
62pub_type
杂志文章,评审abstract::Interleukin (IL)-21 is a member of the γ chain-receptor cytokine family along with IL-2, IL-4, IL-7, IL-9, and IL-15. The effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. IL-21 is secreted by activated CD4 T cells and natural killer T cells. Within CD4 T cells, its secr...
journal_title:Immunologic research
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journal_title:Immunologic research
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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更新日期:2016-08-01 00:00:00
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