Abstract：
:The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such are phosphorylcholine (PC) moieties which are a component of secreted products of helminths. PC has been broadly studied for its attenuating effects on the human immune system. In an attempt to develop a novel therapeutic small molecule for the treatment of autoimmune conditions, we have conjugated PC with tuftsin, a natural immunomodulatory tetrapeptide, to create TPC. Herein, we review our findings regarding the effects of TPC in murine models of three autoimmune diseases-systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), and rheumatic arthritis (RA), as well as ex-vivo samples from giant cell arteritis (GCA) patients. In all four disease models examined, TPC was shown to attenuate the inflammatory response by reducing expression of pro-inflammatory cytokines and altering the phenotype of T cell expression. In murine models, TPC has further produced a significant improvement in clinical disease scores with no significant side effects noted. Our findings suggest TPC presents promising potential as a novel therapeutic agent for the effective treatment of various autoimmune conditions.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Segal Y,Blank M,Shoenfeld Ydoi
10.1007/s12026-018-9051-2subject
Has Abstractpub_date
2018-12-01 00:00:00pages
637-641issue
6eissn
0257-277Xissn
1559-0755pii
10.1007/s12026-018-9051-2journal_volume
66pub_type
杂志文章,评审abstract：:Recent studies have elucidated unanticipated connections between the immune and skeletal systems, and this relationship has led to the development of a new field known as osteoimmunology. The goal of research in this field is to: (1) further understand how the bone microenvironment influences immune cell ontogeny and ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8093-x
更新日期：2009-12-01 00:00:00
abstract：:The coexistence of alopecia areata (AA) and systemic lupus erythematosus (SLE) has been described, but the association between these conditions is yet to be firmly established. We aimed to evaluate the association between AA and SLE using a large-scale real-life computerized database. A cross-sectional study was condu...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-020-09115-x
更新日期：2020-02-01 00:00:00
abstract：:We report on 12 patients with chronic granulomatous disease transplanted with hematopoietic stem cells from matched unrelated (n = 9) or matched sibling donors (n = 3). The most common infectious complication was pulmonary aspergillosis, which nine patients had previously developed. Only 5 of 12 individuals had normal...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-008-8068-3
更新日期：2009-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:26:1-3:223
更新日期：2002-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-018-9046-z
更新日期：2019-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918222
更新日期：1994-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02790403
更新日期：1999-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2001-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/BF02935614
更新日期：1994-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-013-8479-7
更新日期：2014-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-013-8482-z
更新日期：2014-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8147-0
更新日期：2010-07-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918496
更新日期：1995-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-8995-6
更新日期：2018-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8576-2
更新日期：2014-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-016-8876-9
更新日期：2016-12-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-020-09140-w
更新日期：2020-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-011-8237-7
更新日期：2011-10-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8647-z
更新日期：2015-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02919739
更新日期：1991-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8296-4
更新日期：2012-09-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2010-07-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-017-8960-9
更新日期：2018-02-01 00:00:00
abstract：:Monoclonal antibodies (mAb) have been used as targeted treatments against cancer for more than a decade, with mixed results. Research is needed to understand mAb mechanisms of action with the goal of improving the efficacy of currently used mAbs and guiding the design of novel mAbs. While some mAb-induced tumor cell k...
journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2014-08-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/ir:29:1-3:293
更新日期：2004-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:29:1-3:055
更新日期：2004-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8493-4
更新日期：2014-05-01 00:00:00
abstract：:Mast cells (MC) are important effector cells in allergic disorders. Recently, the role of MC in innate and adaptive immunity is gaining prominence. Nitric oxide is an important signaling molecule and its production in mast cell has been reported widely. However, controversy exists about whether MC produce NO. This rev...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:33:3:223
更新日期：2005-01-01 00:00:00
