Immune regulation of viral infection and vice versa.

abstract：:Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by repeated episodes of apnea and hypopnea during sleep. Continuous positive airway pressure (CPAP) is the most effective method for treating OSAS and alleviating the patients' symptoms. The aim of this study was to assess the effect of 3...

journal_title：Immunologic research

authors： Can M,Uygur F,Tanrıverdi H,Acıkgoz B,Alper B,Guven B

更新日期：2016-12-01 00:00:00

abstract：:Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE ...

journal_title：Immunologic research

authors： Zhong XP,Shin J,Gorentla BK,O'Brien T,Srivatsan S,Xu L,Chen Y,Xie D,Pan H

更新日期：2011-04-01 00:00:00

abstract：:EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human host including ZEBRA (BZLF-1 encoded protein), BALF-2 recombinas...

journal_title：Immunologic research

authors： Dreyfus DH,Farina A,Farina GA

更新日期：2018-12-01 00:00:00

abstract：:LSP1 is an F-actin bundling cytoskeletal protein expressed in hematopoietic lineage and endothelial cells. We investigated the function of this protein by generating and analyzing an LSP1-deficient mouse strain and in this review we describe our findings together with those of other investigators. The results show a c...

journal_title：Immunologic research

authors： Jongstra-Bilen J,Jongstra J

更新日期：2006-01-01 00:00:00

abstract：:It has long been known that T cells have the potential to modulate hematopoietic response in different ways. More recently, the importance of interleukin (IL)-17-secreting Th17 cells in T-cell-mediated regulation of hematopoiesis was indicated by the line of evidence that IL-17 links T-cell function and hematopoiesis ...

journal_title：Immunologic research

authors： Krstic A,Mojsilovic S,Jovcic G,Bugarski D

更新日期：2012-04-01 00:00:00

abstract：:Natural killer cells play a major role in innate immunity against tumor and virus-infected cells. NK cells express activating and inhibitory receptors to regulate their function. It has been established that modulation in the NK cell receptor profile results in altered function of NK cell against target cells. Here, w...

journal_title：Immunologic research

authors： Sharma R,Das A

更新日期：2018-02-01 00:00:00

abstract：:CD8+ T cells are critically important for immune defense against many viral and bacterial pathogens, and are also key components of cancer immunotherapy. Help from CD4+ T cells is usually essential for optimal CD8+ T cell responses, driving the primary response, the survival of memory cells, and the generation of prot...

journal_title：Immunologic research

authors： Livingstone AM,Wilson EB,Ontiveros F,Wang JC

更新日期：2009-12-01 00:00:00

abstract：:The role of autoimmune pathology in development and progression of chronic obstructive pulmonary disease (COPD) is becoming increasingly appreciated. In this study, we identified serum autoantibody reactivities associated with chronic bronchitis or emphysema, as well as systemic autoimmunity and associated lung diseas...

journal_title：Immunologic research

authors： Packard TA,Li QZ,Cosgrove GP,Bowler RP,Cambier JC

更新日期：2013-03-01 00:00:00

abstract：:A 20-year-old man developed severe abdominal pain 1 week after being vaccinated with the first dose of quadrivalent human papillomavirus (HPV) vaccine (Gardasil®). Despite ongoing symptoms of nausea and pain, he received the second dose of the vaccine. Only 10 days later, laboratory results revealed significantly elev...

journal_title：Immunologic research

authors： Bizjak M,Bruck O,Praprotnik S,Dahan S,Shoenfeld Y

更新日期：2017-02-01 00:00:00

abstract：:Memory cytotoxic T lymphocytes (CTLs) are able to provide protections to the host against repeated insults from intracellular pathogens. However, it has not been completely understood how the effector functions of memory CTLs are induced upon antigen challenge, which is directly related to the efficacy of their protec...

journal_title：Immunologic research

authors： Lv Y,Mattson E,Bhadurihauck A,Garcia K,Li L,Xiao Z

更新日期：2017-08-01 00:00:00

abstract：:Risk posed by microbial superantigens in triggering or exacerbating SLE in genetically predisposed individuals, thereby altering the response to its treatment strategies, has not been studied. Using streptococcal pyrogenic exotoxin A and staphylococcal enterotoxin B as prototype superantigens, we have demonstrated tha...

journal_title：Immunologic research

authors： Dar SA,Janahi EM,Haque S,Akhter N,Jawed A,Wahid M,Ramachandran VG,Bhattacharya SN,Banerjee BD,Das S

更新日期：2016-08-01 00:00:00

abstract：:IgA nephropathy (IgAN) is an autoimmune disease associated with complement activation. It is unclear whether the ratio of serum C3 and C4 concentrations (C3/C4 ratio) can predict renal outcomes in IgAN patients. A total of 1503 patients diagnosed with IgAN via renal biopsy were recorded in this study. Poor renal outco...

journal_title：Immunologic research

authors： Pan M,Zhou Q,Zheng S,You X,Li D,Zhang J,Chen C,Xu F,Li Z,Zhou Z,Zhang J

更新日期：2018-06-01 00:00:00

abstract：:Corn, soybean, spinach leaf, and tomato aquaporins have been shown to share homology with human aquaporin-4, which is abundantly expressed by brain astrocytic endfeet. Thus, antibodies formed against the dietary aquaporins may potentially cross-react with brain aquaporin, leading to blood-brain barrier permeability an...

journal_title：Immunologic research

authors： Lambert J,Mejia S,Vojdani A

更新日期：2019-02-01 00:00:00

abstract：:The role of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in the exacerbation of inflammatory bowel disease (IBD) is still uncertain. We prospectively investigated the presence of EBV and HCMV infection in both epithelial and immune cells of colonic mucosa of IBD patients, both refractory and responders to...

journal_title：Immunologic research

authors： Ciccocioppo R,Racca F,Scudeller L,Piralla A,Formagnana P,Pozzi L,Betti E,Vanoli A,Riboni R,Kruzliak P,Baldanti F,Corazza GR

更新日期：2016-02-01 00:00:00

abstract：:In recent years, there has been a growing interest in the role of immune, alloimmune and autoimmune processes in the pathogenesis of spontaneous preterm birth and recurrent pregnancy loss. The association between an inflammatory response and preterm labor has been established. Indeed, many women suffering from preterm...

journal_title：Immunologic research

authors： Tsur A,Hughes GC,Shoenfeld Y,Carp H

更新日期：2015-02-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an intractable multifaceted disease with high mortality. Although its pathogenesis is not fully understood, recent studies have advanced our knowledge on SSc. The cardinal pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. The B cells in SSc are constitutively activa...

journal_title：Immunologic research

authors： Furue M,Mitoma C,Mitoma H,Tsuji G,Chiba T,Nakahara T,Uchi H,Kadono T

更新日期：2017-08-01 00:00:00

abstract：:About one half of circulating human B cells express the Leu-8 peripheral lymph node homing receptor that has been implicated in adhesion of lymphocytes and neutrophils to vascular endothelium. A novel and unique function of the Leu-8 antigen has been found in the present study: anti-Leu-8 monoclonal antibody directly ...

journal_title：Immunologic research

authors： Murakawa Y,Strober W,James SP

更新日期：1991-01-01 00:00:00

abstract：:We examine whether B cell lines enriched for DNA specificity from either autoimmune (BWF1) or normal mice (Balb/c) can be rendered unresponsive to autoantigen in terms of the specific suppression of direct antibody-forming cells to DNA. These B cell lines were both Lyt-1 positive and negative. Preincubation with oligo...

journal_title：Immunologic research

authors： Aldo-Benson M,Borel H,Scheiderer-Pratt L,Borel Y

更新日期：1989-01-01 00:00:00

abstract：:Interleukin-2 (IL-2), secreted principally by activated helper T-cells, plays a pivotal role in the generation and regulation of the immune response. The various biologic functions of IL-2 have been the focus of intensive study over the years and have been well worked out. By contrast, an understanding of the intracel...

journal_title：Immunologic research

authors： Lu Y,Durkin JP

更新日期：1997-01-01 00:00:00

abstract：:Pemphigus foliaceus (PF) and Behçet's disease (BD) are immune-mediated conditions which are usually treated with corticosteroids, immunosuppressants, and, when refractory, with biologic agents. In both diseases, interleukin (IL)-6 serum levels are increased driving the immune-mediated inflammatory process. Tocilizumab...

journal_title：Immunologic research

authors： Caso F,Iaccarino L,Bettio S,Ometto F,Costa L,Punzi L,Doria A

更新日期：2013-07-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a chronic autoimmune disease in which β cells are destroyed. Islet transplantation is the most promising therapeutic treatment for T1D patients. However, allograft rejection and autoimmune reaction have been recognized as primary causes of graft loss after transplantation. Alpha-1-antitrypsin ...

journal_title：Immunologic research

authors： Yang L,Liao YT,Yang XF,Reng LW,Qi H,Li FR

更新日期：2015-05-01 00:00:00

abstract：:We have focused our research on understanding the basic biology of and developing novel therapeutic and prophylactic DNA vaccines. We have among others three distinct primary areas of interest which include: 1. Enhancing in vivo delivery and transfection of DNA vaccine vectors 2. Improving DNA vaccine construct immuno...

journal_title：Immunologic research

authors： Abdulhaqq SA,Weiner DB

更新日期：2008-01-01 00:00:00

abstract：:Acute graft-versus-host disease (aGvHD) is still a major cause of transplant-related mortality after allogeneic stem cell transplantation (ASCT). It requires immunosuppressive treatments that broadly abrogate T cell responses including beneficial ones directed against tumor cells or infective pathogens. Polo-like kina...

journal_title：Immunologic research

authors： Berges C,Chatterjee M,Topp MS,Einsele H

更新日期：2016-06-01 00:00:00

abstract：:We describe herein a 61-year-old woman who presented with fever, night sweats and cough. The diagnosis of pneumonia was established, but with symptom recurrence following antibiotic therapy, further diagnostics were performed. Biopsy via bronchoscopy revealed cryptogenic organizing pneumonia, and later on follow-up, a...

journal_title：Immunologic research

authors： Gueta I,Shoenfeld Y,Orbach H

更新日期：2014-12-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine expressed mainly by epithelial cells. Current studies provide compelling evidence that TSLP is capable of activating dendritic cells to promote T helper (Th) 2 immune responses. TSLP has also been shown to directly promote Th2 differentiation of naï...

journal_title：Immunologic research

authors： Zhang Y,Zhou B

更新日期：2012-06-01 00:00:00

abstract：:For the last decade, we have focused on guanylyl cyclase C (GUCY2C) as a potentially ideal target antigen for colorectal cancer immunotherapy. GUCY2C is expressed only in intestinal epithelial cells and by nearly 100% of colorectal cancers. We have developed and tested a recombinant adenoviral vector possessing GUCY2C...

journal_title：Immunologic research

authors： Snook AE,Magee MS,Waldman SA

更新日期：2011-12-01 00:00:00

abstract：:Considerable progress has been made in understanding the Fas pathway at the molecular and cellular levels, but fundamental questions about the overall biological role of the Fas pathway remain unresolved. A major question is why lymphoproliferation caused by the lpr mutation of Fas and gld mutation of FasL ligand (Fas...

journal_title：Immunologic research

authors： Hamad AR

更新日期：2010-07-01 00:00:00

abstract：:Many clues point to a role for T lymphocytes in the pathogenesis of rheumatoid arthritis (RA), although the importance of these cells and their position within the rheumatoid pathogenic scheme remain unknown. Encouraged by data from animal models of T-lymphocyte-mediated autoimmunity, a major focus of research into th...

journal_title：Immunologic research

authors： Zwillich SH,Weiner DB,Williams WV

更新日期：1994-01-01 00:00:00

abstract：:Herpes simplex virus type 1 infection of the mouse eye results in an impressive inflammatory response culminating in the death of the animal or the establishment of a "latent" infection depending on a number of ill-defined variables that include components of the innate and adaptive immune system. The application of t...

journal_title：Immunologic research

authors： Wickham S,Ash J,Lane TE,Carr DJ

更新日期：2004-01-01 00:00:00

abstract：:C3d is the final degradation product of the third component of complement (C3). When conjugated to an antigen, C3d enhances immune responses to the fused antigen. Therefore, this molecule has been used as an adjuvant to enhance the immune responses to various foreign and self-proteins. C3d binds to the complement rece...

journal_title：Immunologic research

authors： Toapanta FR,Ross TM

更新日期：2006-01-01 00:00:00