Immune protective effect of human alpha-1-antitrypsin gene during β cell transplantation in diabetic mice.

abstract：:The role of autoimmune pathology in development and progression of chronic obstructive pulmonary disease (COPD) is becoming increasingly appreciated. In this study, we identified serum autoantibody reactivities associated with chronic bronchitis or emphysema, as well as systemic autoimmunity and associated lung diseas...

journal_title：Immunologic research

authors： Packard TA,Li QZ,Cosgrove GP,Bowler RP,Cambier JC

更新日期：2013-03-01 00:00:00

abstract：:Invariant CD1d-restricted natural killer T (iNKT) cells function during innate and adaptive immune responses. A functional and numerical deficiency of iNKT cells is well documented in both nonobese diabetic (NOD) mice and humans with autoimmune type 1 diabetes (T1D). Restoring the numerical and/or functional deficienc...

journal_title：Immunologic research

authors： Hussain S,Wagner M,Ly D,Delovitch TL

更新日期：2005-01-01 00:00:00

abstract：:B cell development starts in the bone marrow where hematopoietic stem cells (HSCs) progress through sequential developmental stages, as it differentiates into a naïve B cell expressing surface immunoglobulin. In the periphery, B cells that encounter antigen can further differentiate into antibody-secreting plasma cell...

journal_title：Immunologic research

authors： Santos P,Arumemi F,Park KS,Borghesi L,Milcarek C

更新日期：2011-08-01 00:00:00

abstract：:Modulating PI3K at different stages of dendritic cells (DC) generation could be a novel means to balance the generation of immunosuppressive versus immunostimulatory DC. We show that PI3K inhibition during mouse DC generation in vitro results in cells that are potently immunosuppressive and characteristic of CD8alpha-...

journal_title：Immunologic research

authors： Di Caro V,D'Anneo A,Phillips B,Engman C,Harnaha J,Trucco M,Giannoukakis N

更新日期：2011-08-01 00:00:00

abstract：:Heat shock proteins (HSPs) are evolutionarily highly conserved polypeptides synthesized by many cells to preserve cellular functions under a variety of stressful conditions including infections. We have investigated the involvement of 65-kDa HSP (HSP65) in host protection against an intracellular protozoan parasite, T...

journal_title：Immunologic research

authors： Himeno K,Hisaeda H

更新日期：1996-01-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well as prime disparate T-cell helper responses. Yet, there is increasing e...

journal_title：Immunologic research

authors： Barchet W,Blasius A,Cella M,Colonna M

更新日期：2005-01-01 00:00:00

abstract：:The key role of T cells in hepatitis C virus (HCV) elimination and the ability of dendritic cells (DCs) to induce antiviral T cell responses suggest that DC vaccines could be a promising approach in the treatment of chronic HCV infection. The aim of our study was to evaluate, whether immunotherapy with DCs is safe and...

journal_title：Immunologic research

authors： Chernykh E,Leplina O,Oleynik E,Tikhonova M,Tyrinova T,Starostina N,Ostanin A

更新日期：2018-02-01 00:00:00

abstract：:The attributes of specificity and memory enable CD8(+) T cells to provide long-lasting protection against a variety of challenges. Although, the importance of CD8(+) T cells for protection against intracellular infections and transformation is well-established, the functional type; effector phenotypes (Tc1, Tc2, Tc17 ...

journal_title：Immunologic research

authors： Shrikant PA,Rao R,Li Q,Kesterson J,Eppolito C,Mischo A,Singhal P

更新日期：2010-03-01 00:00:00

abstract：:p-Phenylenediamine (PPD) and Diphenylcyclopropenone (DPCP) are two potent haptens. Both haptens are known to cause delayed-type hypersensitivity, involving a cytokine response and local infiltration of T-cell subpopulations, resulting in contact dermatitis. We investigated the systemic immune effects of PPD and DPCP, ...

journal_title：Immunologic research

authors： Svalgaard JD,Særmark C,Dall M,Buschard K,Johansen JD,Engkilde K

更新日期：2014-01-01 00:00:00

abstract：:The Caenorhabditis elegans model can be used to study Candida albicans virulence and host immunity, as well as to identify plant-derived natural products to use against C. albicans. Thymol is a hydrophobic phenol compound from the aromatic plant thyme. In this study, the in vitro data demonstrated concentration-depend...

journal_title：Immunologic research

authors： Shu C,Sun L,Zhang W

更新日期：2016-08-01 00:00:00

abstract：:Contact hypersensitivity (CHS) is a T cell-mediated immune response to cutaneous sensitization and subsequent challenge with haptens such as dinitrofluorobenzene and oxazolone. Many aspects concerning the development and regulation of CHS remain unknown. Using CHS as a model of T cell-mediated immune responses to anti...

journal_title：Immunologic research

authors： Gorbachev AV,Fairchild RL

更新日期：2001-01-01 00:00:00

abstract：:The participation of inflammatory cells in atherosclerosis is a well-known process that involves numerous molecules including chemotactic cytokines (chemokines) for their entry into the vessel wall. Although the C-C chemokine monocyte chemoattractant protein-1 and its receptor, CCR2, have been implicated in atheroscle...

journal_title：Immunologic research

authors： Boisvert WA,Curtiss LK,Terkeltaub RA

更新日期：2000-01-01 00:00:00

abstract：:Major histocompatibility (MHC) class II molecules function to present antigenic peptides to CD4 T lymphocytes. The pathways by which these molecules present exogenous antigens have been extensively studied. However by contrast, far less is known about the processing and trafficking of cytosolic antigens, which can als...

journal_title：Immunologic research

authors： Zhou D,Blum JS

更新日期：2004-01-01 00:00:00

abstract：:Recent studies have elucidated unanticipated connections between the immune and skeletal systems, and this relationship has led to the development of a new field known as osteoimmunology. The goal of research in this field is to: (1) further understand how the bone microenvironment influences immune cell ontogeny and ...

journal_title：Immunologic research

authors： Mensah KA,Li J,Schwarz EM

更新日期：2009-12-01 00:00:00

abstract：:The intestinal epithelium serves as one of human's primary interfaces with the outside world. This interface is very heavily colonized with bacteria and yet permits absorption of life-sustaining nutrients while protecting the tissues below from microbial onslaught. Although the gut epithelium had been classically thou...

journal_title：Immunologic research

authors： Yu Y,Sitaraman S,Gewirtz AT

更新日期：2004-01-01 00:00:00

abstract：:Development can occur by either instructive or stochastic processes. My colleagues and I have studied the contributions of these processes to differentiation of naïve CD4+ T-cells to either a Th1 or Th2 phenotype. Our initial discovery that pathogens in our in vitro priming system led to the development of Th1 cells t...

journal_title：Immunologic research

authors： Murphy KM

更新日期：2005-01-01 00:00:00

abstract：:The development and increasing diffusion of new vaccinations and global immunization protocols have aroused burning debates about safety of adjuvants and their immunogenicity-enhancing effect in vaccines. Shoenfeld and Agmon-Levin have grouped under the term "autoimmune/inflammatory syndrome induced by adjuvants" (ASI...

journal_title：Immunologic research

authors： Esposito S,Prada E,Mastrolia MV,Tarantino G,Codecà C,Rigante D

更新日期：2014-12-01 00:00:00

abstract：:T helper (Th) lymphocytes differentiate into two distinct subsets--Th1 and Th2--as defined by functional abilities and cytokine profiles. The functional differences between Th subsets are explained primarily through the activities of the cytokines they secrete. Interferon-gamma (IFN-gamma) is the signature cytokine of...

journal_title：Immunologic research

authors： Singh VK,Rai G

更新日期：2001-01-01 00:00:00

abstract：:C3d is the final degradation product of the third component of complement (C3). When conjugated to an antigen, C3d enhances immune responses to the fused antigen. Therefore, this molecule has been used as an adjuvant to enhance the immune responses to various foreign and self-proteins. C3d binds to the complement rece...

journal_title：Immunologic research

authors： Toapanta FR,Ross TM

更新日期：2006-01-01 00:00:00

abstract：:The role of gamma/delta T cells in immunity to bacterial infection and control of inflammation is discussed. Special emphasis is placed on the use of murine models in which various aspects of immune function can be monitored in the absence of gamma/delta T cells. Issues discussed include the response to and control of...

journal_title：Immunologic research

authors： Ziegler HK

更新日期：2004-01-01 00:00:00

abstract：:The etiology of polyarteritis nodosa (PAN) and localized PAN, including cutaneous arteritis (CA), remains unknown; however, initial endothelial damage has been implicated. The intima of the vasculitis lesions is predominantly infiltrated by innate-like bystander-activated CD8 T cells, in addition to the macrophages. M...

journal_title：Immunologic research

authors： Kobayashi M,Matsumoto Y,Satomi H,Tateishi A,Ohya M,Ito I,Kanno H

更新日期：2020-06-01 00:00:00

abstract：:Kv1.3 and IKCa1 lymphocyte potassium channels have been implicated as important targets of selective immunomodulation. We compared the alterations in cytokine production upon selective inhibition of Kv1.3 or IKCa1 channels (by MGTX and TRAM, respectively) in healthy donors (HD), RA and AS patients. We also determined ...

journal_title：Immunologic research

authors： Toldi G,Munoz L,Herrmann M,Schett G,Balog A

更新日期：2016-04-01 00:00:00

abstract：:Thermal injury, as well as other forms of severe trauma, induces simultaneous hyper- and anti-inflammatory response. While data about decreased number and responsiveness of T lymphocytes are largely consistent, reports concerning granulocytes following trauma are contradictory. Contrary to the evidence on the increase...

journal_title：Immunologic research

authors： Draskovic-Pavlovic B,Vucevic D,Bozic B,Majstorovic I,Colic M

更新日期：2012-04-01 00:00:00

abstract：:It has long been known that T cells have the potential to modulate hematopoietic response in different ways. More recently, the importance of interleukin (IL)-17-secreting Th17 cells in T-cell-mediated regulation of hematopoiesis was indicated by the line of evidence that IL-17 links T-cell function and hematopoiesis ...

journal_title：Immunologic research

authors： Krstic A,Mojsilovic S,Jovcic G,Bugarski D

更新日期：2012-04-01 00:00:00

abstract：:CD23, also known as the low affinity receptor for IgE (Fc epsilon RII), belongs to a novel superfamily of type-II integral membrane proteins. Fc epsilon RII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by severa...

journal_title：Immunologic research

authors： Sarfati M,Fournier S,Wu CY,Delespesse G

更新日期：1992-01-01 00:00:00

abstract：:CD62L governs the circulation of CD8(+) T cells between lymph nodes and peripheral tissues, whereby the expression of CD62L by CD8(+) T cells promotes their recirculation through lymph nodes. As such, CD62L participates in the fate of adoptively transferred CD8(+) T cells and may control their effectiveness for cancer...

journal_title：Immunologic research

authors： Díaz-Montero CM,Zidan AA,Pallin MF,Anagnostopoulos V,Salem ML,Wieder E,Komanduri K,Montero AJ,Lichtenheld MG

更新日期：2013-12-01 00:00:00

abstract：:Mutations of the Wiskott-Aldrich Syndrome Protein (WASP) are responsible for classic Wiskott-Aldrich Syndrome (WAS), X-linked thrombocytopenia (XLT), and in rare instances congenital X-linked neutropenia (XLN). WASP is a regulator of actin polymerization in hematopoietic cells with well-defined functional domains that...

journal_title：Immunologic research

authors： Ochs HD

更新日期：2009-01-01 00:00:00

abstract：:Systemic lupus erythematosus is a severe autoimmune disease that affects multiple organ systems resulting in diverse symptoms and outcomes. It is characterized by antibody production to a variety of self-antigens, but it is specifically associated with those against anti-dsDNA. Anti-dsDNA antibodies are present before...

journal_title：Immunologic research

authors： Giles BM,Boackle SA

更新日期：2013-03-01 00:00:00

abstract：:Interleukin (IL)-21 is a member of the γ chain-receptor cytokine family along with IL-2, IL-4, IL-7, IL-9, and IL-15. The effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. IL-21 is secreted by activated CD4 T cells and natural killer T cells. Within CD4 T cells, its secr...

journal_title：Immunologic research

authors： Pallikkuth S,Pahwa S

更新日期：2013-12-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine expressed mainly by epithelial cells. Current studies provide compelling evidence that TSLP is capable of activating dendritic cells to promote T helper (Th) 2 immune responses. TSLP has also been shown to directly promote Th2 differentiation of naï...

journal_title：Immunologic research

authors： Zhang Y,Zhou B

更新日期：2012-06-01 00:00:00