Abstract:
:p-Phenylenediamine (PPD) and Diphenylcyclopropenone (DPCP) are two potent haptens. Both haptens are known to cause delayed-type hypersensitivity, involving a cytokine response and local infiltration of T-cell subpopulations, resulting in contact dermatitis. We investigated the systemic immune effects of PPD and DPCP, two relatively unexplored skin allergens. The dorsal sides of the ears of BALB/c mice were exposed to PPD or DPCP (0.1% w/v or 0.01% w/v), or vehicle alone. Mice were treated once daily for 3 days (induction period) and subsequently twice per week for 8 weeks. Local and systemic immune responses in the auricular and pancreatic lymph nodes, spleen, liver, serum, and ears were analyzed with cytokine profiling MSD, flow cytometry, and qPCR. Ear swelling increased significantly in mice treated with 1% PPD, 0.01% DPCP or 0.1% DPCP, compared with vehicle treatment, indicating that the mice were sensitized and that there was a local inflammation. Auricular lymph nodes, pancreatic lymph nodes, spleen, and liver showed changes in regulatory T-cell, B-cell, and NKT-cell frequencies, and increased activation of CD8(+) T cells and B cells. Intracellular cytokine profiling revealed an increase in the IFN-γ- and IL-4-positive NKT cells present in the liver following treatment with both haptens. Moreover, we saw a tendency toward a systemic increase in IL-17A. We observed systemic immunological effects of PPD and DPCP. Furthermore, concentrations too low to increase ear thickness and cause clinical symptoms may still prime the immune system. These systemic immunological effects may potentially predispose individuals to certain diseases.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Svalgaard JD,Særmark C,Dall M,Buschard K,Johansen JD,Engkilde Kdoi
10.1007/s12026-013-8482-zsubject
Has Abstractpub_date
2014-01-01 00:00:00pages
40-50issue
1eissn
0257-277Xissn
1559-0755journal_volume
58pub_type
杂志文章abstract::Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to stu...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-009-8136-3
更新日期:2010-07-01 00:00:00
abstract::Schizophrenia is considered to be of the severe psychiatric disorders characterized by chronic debilitating course marked with frequent relapses and high clinical and financial burden. Aberrations of thyroid hormone levels have been documented in several psychiatric conditions including bipolar disease. The aim of thi...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-018-9030-7
更新日期:2018-12-01 00:00:00
abstract::Contact hypersensitivity (CHS) is a T cell-mediated immune response to cutaneous sensitization and subsequent challenge with haptens such as dinitrofluorobenzene and oxazolone. Many aspects concerning the development and regulation of CHS remain unknown. Using CHS as a model of T cell-mediated immune responses to anti...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:24:1:69
更新日期:2001-01-01 00:00:00
abstract::Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work wil...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-007-0017-z
更新日期:2007-01-01 00:00:00
abstract::CD23, also known as the low affinity receptor for IgE (Fc epsilon RII), belongs to a novel superfamily of type-II integral membrane proteins. Fc epsilon RII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by severa...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02919132
更新日期:1992-01-01 00:00:00
abstract::We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all environmental factors contributing to the development of disease and studies the sum total of bur...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-013-8399-6
更新日期:2013-07-01 00:00:00
abstract::During thymocyte development bone marrow-derived precursors in the thymus undergo a series of differentiation steps to produce self-tolerant, mature T lymphocytes. The thymus contains two functionally distinct anatomical compartments, consisting of a centrally located medulla surrounded by the thymic cortex. These com...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-012-8301-y
更新日期:2012-12-01 00:00:00
abstract::Systemic autoimmune or granulomatous disorders related to biomaterials of human use have rarely been described. The aim of this study was to report cases of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) related to biomaterial injections and prostheses, mainly silicone, hyaluronic acid, acrylamides and m...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-017-8980-5
更新日期:2018-02-01 00:00:00
abstract::Cytolytic effector function fails to develop if proliferation of allospecific cytolytic T lymphocyte precursors is inhibited, but the requirements for generation of cytolytic activity have not been fully defined. In contrast, the cytolytic effector function of cytolytic T lymphocyte clones does not change during the c...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/BF02935614
更新日期:1994-01-01 00:00:00
abstract::Thermal injury, as well as other forms of severe trauma, induces simultaneous hyper- and anti-inflammatory response. While data about decreased number and responsiveness of T lymphocytes are largely consistent, reports concerning granulocytes following trauma are contradictory. Contrary to the evidence on the increase...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-012-8280-z
更新日期:2012-04-01 00:00:00
abstract::The etiology of polyarteritis nodosa (PAN) and localized PAN, including cutaneous arteritis (CA), remains unknown; however, initial endothelial damage has been implicated. The intima of the vasculitis lesions is predominantly infiltrated by innate-like bystander-activated CD8 T cells, in addition to the macrophages. M...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-020-09140-w
更新日期:2020-06-01 00:00:00
abstract::With several different CAR T cell therapies under advanced phases of clinical trials, and the first FDA-approved CAR treatments in 2017 (Yescarta and Kymriah), CAR T cell therapy has become one of the most promising therapies for the treatment of certain types of cancer. This success has bred an opportunity to optimiz...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-020-09119-7
更新日期:2020-02-01 00:00:00
abstract::Building on significant advances in basic tumor immunology over the past decade, current translational efforts to develop novel antitumor T cell therapeutics continue to accelerate. Both passive T cell immunotherapy (e.g., adoptive T cell transfusions) and active immunotherapy (e.g., vaccination) may eventually become...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:27:2-3:341
更新日期:2003-01-01 00:00:00
abstract::Histones appear in plasma during infectious or non-infectious sepsis and are associated with multiorgan injury. In the current studies, intravenous infusion of histones resulted in their localization in major organs. In vitro exposure of mouse macrophages to histones caused a buildup of histones on cell membranes foll...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8628-2
更新日期:2015-03-01 00:00:00
abstract::Modulating PI3K at different stages of dendritic cells (DC) generation could be a novel means to balance the generation of immunosuppressive versus immunostimulatory DC. We show that PI3K inhibition during mouse DC generation in vitro results in cells that are potently immunosuppressive and characteristic of CD8alpha-...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-011-8206-1
更新日期:2011-08-01 00:00:00
abstract::Diabetes is a chronic autoimmune disease that affects 4-5% of the world's population. If the present trends continue, diabetes would soon become a major/leading health problem worldwide. Hence there is an urgent need to develop novel approaches for the treatment of diabetes. While transplantation of the pancreas or th...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-007-0070-7
更新日期:2007-01-01 00:00:00
abstract::Systemic sclerosis (SSc) is an intractable multifaceted disease with high mortality. Although its pathogenesis is not fully understood, recent studies have advanced our knowledge on SSc. The cardinal pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. The B cells in SSc are constitutively activa...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-017-8926-y
更新日期:2017-08-01 00:00:00
abstract::Dendritic cells (DCs) are considered a very promising arm to activate the immune system in immunotherapeutic strategies against cancer. DCs are the most powerful antigen-presenting cells (APCs), being highly efficient at generating robust immune responses. They are also considered the center of the immune system, sinc...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-017-8931-1
更新日期:2017-08-01 00:00:00
abstract::Assembly of the class I MHC molecule is inextricably linked to the antigen presentation function of the class I molecule. Association of the class I MHC molecule with beta 2-microglobulin (beta 2m) is a prerequisite for association with the heterodimeric protein TAP, and once peptide is acquired, the class I molecule ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02918217
更新日期:1995-01-01 00:00:00
abstract::The indigenous oral microflora and the host are normally in a state of equilibrium; however, the introduction of a pathogen can result in innate and adaptive immune responses that either contribute to the development of the disease or lead to host immunity. The interactions between the microorganisms and the host are ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:26:1-3:223
更新日期:2002-01-01 00:00:00
abstract::Limited protective effects of commercially available vaccines necessitate the development of novel pneumococcal vaccines. We recently reported a pneumococcal systemic vaccine containing two proteins, Pneumococcal surface protein A (PspA of family 1 and 2) and a bacterium-like particle-based pneumococcal mucosal vaccin...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-019-09107-6
更新日期:2019-10-01 00:00:00
abstract::The MHC class II antigen processing pathway provides a mechanism to selectively present peptides generated in the endosomal compartments of antigen presenting cells to CD4+ T cells. Transport of newly synthesized class II molecules to the endosomal pathway requires the function of an accessory protein, invariant chain...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02790403
更新日期:1999-01-01 00:00:00
abstract::The Cluster of differentiation 226(CD226)/T cell immunoglobulin and immune receptor tyrosine-based inhibitory motif domain (TIGIT) axis plays an important role in the balance of the immune response. A previous study showed that CD226 is involved in CD4+ T cell differentiation and that blocking CD226 may attenuate expe...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-019-09112-9
更新日期:2019-12-01 00:00:00
abstract::Although the B-cell antigen receptor (BCR) factors most prominently in the maintenance and differentiation of mature B cells, it is now appreciated that co-receptor molecules can positively or negatively modulate signals through the BCR. Co-receptors are functionally defined as modifiers of BCR engagement and signal t...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:31:2:119
更新日期:2005-01-01 00:00:00
abstract::Heat shock proteins (HSPs) are evolutionarily highly conserved polypeptides synthesized by many cells to preserve cellular functions under a variety of stressful conditions including infections. We have investigated the involvement of 65-kDa HSP (HSP65) in host protection against an intracellular protozoan parasite, T...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02918253
更新日期:1996-01-01 00:00:00
abstract::Pemphigus foliaceus (PF) and Behçet's disease (BD) are immune-mediated conditions which are usually treated with corticosteroids, immunosuppressants, and, when refractory, with biologic agents. In both diseases, interleukin (IL)-6 serum levels are increased driving the immune-mediated inflammatory process. Tocilizumab...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-013-8411-1
更新日期:2013-07-01 00:00:00
abstract::An effective host response against viral infection of the central nervous system (CNS) is the principal factor dictating the outcome of infection. It is the responsibility of the immune response to contain and control viral replication. Paradoxically, it is the immune response that may also contribute to the developme...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:24:2:111
更新日期:2001-01-01 00:00:00
abstract::The aim of this study was to determine whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to Behcet's disease (BD). A meta-analysis was conducted, examining the associations between the IL-10 - 1082 G/A, - 819 C/T, and - 592 C/A polymorphisms and BD in various ethnic groups. Fourteen studi...
journal_title:Immunologic research
pub_type: 杂志文章,meta分析
doi:10.1007/s12026-019-09102-x
更新日期:2019-10-01 00:00:00
abstract::We have recently established new bone marrow transplantation (BMT) methods for the treatment of intractable diseases. The methods include the perfusion method (PM) for the collection of bone marrow cells, and intra-bone marrow (IBM)-BMT for the direct injection of collected whole bone marrow cells into the bone marrow...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-007-0004-4
更新日期:2007-01-01 00:00:00
abstract::Immunological memory is a hallmark of adaptive immunity, a defense mechanism endowed to vertebrates during evolution. However, an autoimmune pathogenic role of memory lymphocytes is also emerging with accumulating evidence, despite reasonable skepticism on their existence in a chronic setting of autoimmune damage. It ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-013-8448-1
更新日期:2013-12-01 00:00:00