HLA-DM and the MHC class II antigen presentation pathway.

abstract：:The examination of the immune T cell response to herpes simplex virus (HSV) antigen glycoprotein D (gD) in an ongoing infection has revealed a uniquely broad range of antigenic determinants seen. This has been shown in the murine T cell response to gD determinants where over 60% of the overlapping peptides are recogni...

journal_title：Immunologic research

authors： Heber-Katz E

更新日期：1998-01-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well as prime disparate T-cell helper responses. Yet, there is increasing e...

journal_title：Immunologic research

authors： Barchet W,Blasius A,Cella M,Colonna M

更新日期：2005-01-01 00:00:00

abstract：:Recent advances in molecular medicine have shown that soluble MHC-multimers can be valuable tools for both analysis and modulation of antigen-specific immune responses in vitro and in vivo. In this review, we describe the use of dimeric human and mouse major histocompatibility complexes, MHC-Ig, as part of an artifici...

journal_title：Immunologic research

authors： Oelke M,Schneck JP

更新日期：2010-07-01 00:00:00

abstract：:Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work wil...

journal_title：Immunologic research

authors： Carrero JA,Unanue ER

更新日期：2007-01-01 00:00:00

abstract：:Contact hypersensitivity (CHS) is a T cell-mediated immune response to cutaneous sensitization and subsequent challenge with haptens such as dinitrofluorobenzene and oxazolone. Many aspects concerning the development and regulation of CHS remain unknown. Using CHS as a model of T cell-mediated immune responses to anti...

journal_title：Immunologic research

authors： Gorbachev AV,Fairchild RL

更新日期：2001-01-01 00:00:00

abstract：:Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to ...

journal_title：Immunologic research

authors： Infantino M,Meacci F,Grossi V,Manfredi M,Li Gobbi F,Sarzi-Puttini P,Atzeni F,Benucci M

更新日期：2017-02-01 00:00:00

abstract：:Apoptosis, programmed cell death, eliminates injured or harmful cells. It can mediate its response through the actions of death ligands including TRAIL. TRAIL, a member of TNF superfamily, induces apoptosis of transformed cells through the action of death domain receptors DR-4 and DR5. It directly induces apoptosis th...

journal_title：Immunologic research

authors： Chaudhari BR,Murphy RF,Agrawal DK

更新日期：2006-01-01 00:00:00

abstract：:The "X chromosome-nucleolus nexus" hypothesis provides a comprehensive explanation of how autoantibodies can develop following cellular stress. The hypothesis connects autoimmune diseases with the impact of environmental factors, such as viruses, through epigenetic disruption. The inactive X chromosome, a major epigen...

journal_title：Immunologic research

authors： Brooks WH

更新日期：2018-12-01 00:00:00

abstract：:Recent studies have elucidated unanticipated connections between the immune and skeletal systems, and this relationship has led to the development of a new field known as osteoimmunology. The goal of research in this field is to: (1) further understand how the bone microenvironment influences immune cell ontogeny and ...

journal_title：Immunologic research

authors： Mensah KA,Li J,Schwarz EM

更新日期：2009-12-01 00:00:00

abstract：:C3d is the final degradation product of the third component of complement (C3). When conjugated to an antigen, C3d enhances immune responses to the fused antigen. Therefore, this molecule has been used as an adjuvant to enhance the immune responses to various foreign and self-proteins. C3d binds to the complement rece...

journal_title：Immunologic research

authors： Toapanta FR,Ross TM

更新日期：2006-01-01 00:00:00

abstract：:Anti-CD3 monoclonal antibodies (MAbs) were developed as a way of inducing immune suppression of T cells. More recent studies have indicated that anti-CD3 MAbs can affect immune responses by inducing immune regulation. We recently reported that a single course of treatment with a non-FcR binding anti-CD3 MAb, hOKT3gamm...

journal_title：Immunologic research

authors： Herold KC,Taylor L

更新日期：2003-01-01 00:00:00

abstract：:In recent years, there has been a profound change in autoimmune diagnostics. From long, tiring and inaccurate manual methods, the art of diagnostics has turned to modern, rapid and automated technology. New antibody tests have been developed, and almost all autoimmune diseases now have some specific diagnostic markers...

journal_title：Immunologic research

authors： Bizzaro N,Tozzoli R,Villalta D

更新日期：2015-02-01 00:00:00

abstract：:We describe herein a 61-year-old woman who presented with fever, night sweats and cough. The diagnosis of pneumonia was established, but with symptom recurrence following antibiotic therapy, further diagnostics were performed. Biopsy via bronchoscopy revealed cryptogenic organizing pneumonia, and later on follow-up, a...

journal_title：Immunologic research

authors： Gueta I,Shoenfeld Y,Orbach H

更新日期：2014-12-01 00:00:00

abstract：:Interleukin (IL)-21 is a member of the γ chain-receptor cytokine family along with IL-2, IL-4, IL-7, IL-9, and IL-15. The effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. IL-21 is secreted by activated CD4 T cells and natural killer T cells. Within CD4 T cells, its secr...

journal_title：Immunologic research

authors： Pallikkuth S,Pahwa S

更新日期：2013-12-01 00:00:00

abstract：:Cytolytic effector function fails to develop if proliferation of allospecific cytolytic T lymphocyte precursors is inhibited, but the requirements for generation of cytolytic activity have not been fully defined. In contrast, the cytolytic effector function of cytolytic T lymphocyte clones does not change during the c...

journal_title：Immunologic research

authors： Cronin DC 2nd,Lancki DW,Fitch FW

更新日期：1994-01-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a T cell mediated demyelinating disease of the central nervous system (CNS) that serves as a model for multiple sclerosis (MS). Insights into the pathogenesis of this model may help scientists understand the human disease and aid in rational drug discovery. In this re...

journal_title：Immunologic research

authors： Elhofy A,Kennedy KJ,Fife BT,Karpus WJ

更新日期：2002-01-01 00:00:00

abstract：:γδ T cells represent a relevant proportion of T lymphocytes that express T cell receptors (TCRs) encoded by the γ and δ T cell receptor genes. Whereas the most circulating γδ T cell type, Vδ2 T cells, has been described and studied intensively, the potential role of Vδ1 T cells remains largely unclear. Here, we identi...

journal_title：Immunologic research

authors： Hua F,Kang N,Gao YA,Cui LX,Ba DN,He W

更新日期：2013-05-01 00:00:00

abstract：:Previous studies by our group, using an experimental autoimmune thyroiditis (EAT) model in Strain 13 inbred guinea pigs, resulted in T cell-mediated delayed hypersensitivity; however, autoantibodies proved not to be cytotoxic to thyroid epithelial cells in the presence or absence of complement proteins. Albeit, T cell...

journal_title：Immunologic research

authors： Lin MS,Tse HM,Delmastro MM,Bertera S,Wong CT,Lakomy R,He J,Sklavos MM,Coudriet GM,Pietropaolo M,Trucco MM,Piganelli JD

更新日期：2011-08-01 00:00:00

abstract：:Herpes simplex virus type 1 infection of the mouse eye results in an impressive inflammatory response culminating in the death of the animal or the establishment of a "latent" infection depending on a number of ill-defined variables that include components of the innate and adaptive immune system. The application of t...

journal_title：Immunologic research

authors： Wickham S,Ash J,Lane TE,Carr DJ

更新日期：2004-01-01 00:00:00

abstract：:Chronic inflammation mediated by microglial cells is the fundamental process contributing to the death of dopamine (DA)-producing neurons in the brain. Production of inflammatory products by these microglial cells characterizes the slow destructive process in Parkinson's disease (PD). The activation of microglial cell...

journal_title：Immunologic research

authors： Qian L,Flood PM

更新日期：2008-01-01 00:00:00

abstract：:The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such are phosphorylcholine (PC) moieties which are a component of secreted products of helminths. PC has been broadl...

journal_title：Immunologic research

authors： Segal Y,Blank M,Shoenfeld Y

更新日期：2018-12-01 00:00:00

abstract：:The Cluster of differentiation 226(CD226)/T cell immunoglobulin and immune receptor tyrosine-based inhibitory motif domain (TIGIT) axis plays an important role in the balance of the immune response. A previous study showed that CD226 is involved in CD4+ T cell differentiation and that blocking CD226 may attenuate expe...

journal_title：Immunologic research

authors： Wang N,Liang S,Jin J,Fang L,Ma Q,Wang X,Song Y,Chen L

更新日期：2019-12-01 00:00:00

abstract：:Many clues point to a role for T lymphocytes in the pathogenesis of rheumatoid arthritis (RA), although the importance of these cells and their position within the rheumatoid pathogenic scheme remain unknown. Encouraged by data from animal models of T-lymphocyte-mediated autoimmunity, a major focus of research into th...

journal_title：Immunologic research

authors： Zwillich SH,Weiner DB,Williams WV

更新日期：1994-01-01 00:00:00

abstract：:Purified protein derivative (PPD) or tuberculin skin testing is used to identify infected individuals with Mycobacterium tuberculosis (Mtb) and to assess cell-mediated immunity to Mtb. In the present study, we compared PBMC cultures in the presence of tuberculin or Candida antigens using cytokine bead arrays and RNA m...

journal_title：Immunologic research

authors： Stern JN,Keskin DB,Romero V,Zuniga J,Encinales L,Li C,Awad C,Yunis EJ

更新日期：2009-01-01 00:00:00

abstract：:It is now apparent that naïve peripheral T cells are a dynamic population where active processes prevent inappropriate activation while supporting survival. The process of thymic education makes naïve peripheral T cells dependent on interactions with self-MHC for survival. However, as these signals can potentially res...

journal_title：Immunologic research

authors： Modiano JF,Johnson LD,Bellgrau D

更新日期：2008-01-01 00:00:00

abstract：:This is a journey that began in medical school at Stanford in 1963 and that is still underway, now as faculty member here for the past 40 years. History is by its nature selective, and I chose highlights that reflect on the remarkable progress we have made using the immune system to treat cancer. We will never be sati...

journal_title：Immunologic research

authors： Levy R

更新日期：2014-05-01 00:00:00

abstract：:Type I diabetes (T1D) is a chronic autoimmune disease caused by pancreatic β-cell destruction induced by autoantibodies and autoreactive T cells. After significant reduction of the β-cell mass, diabetes sets in and can cause significant complications. It is estimated that more than 3 million Americans have T1D, and it...

journal_title：Immunologic research

authors： Manzar GS,Kim EM,Rotti P,Zavazava N

更新日期：2014-08-01 00:00:00

abstract：:Nitric oxide (.NO) is a freely diffusible inter- and intracellular messenger produced by a variety of mammalian cells including vascular endothelium, neurons, smooth muscle cells, macrophages, neutrophils, platelets, and pulmonary epithelium. In smooth muscle cells, platelets, and neutrophils, .NO raises intracellular...

journal_title：Immunologic research

authors： Aslan M,Freeman BA

更新日期：2002-01-01 00:00:00

abstract：:Chronic infections have been a major topic of investigation in recent years, but the mechanisms that dictate whether or not a pathogen is successfully controlled are incompletely understood. Cytomegalovirus (CMV) is a herpesvirus that establishes a persistent infection in the majority of people in the world. Like othe...

journal_title：Immunologic research

authors： Snyder CM

更新日期：2011-12-01 00:00:00

abstract：:The aim of the present study was to examine the role and mechanism of interleukin-10 (IL-10)-producing regulatory B cells (B10 cells) in the pathogenesis of Henoch-Schönlein purpura nephritis (HSPN). We examined the percentage of B10 cells, CD19+CD24hiCD38hi B cells, CD19+CD24hiCD27+ B cells, Th17 cells, and T regulat...

journal_title：Immunologic research

authors： Yang B,Tan X,Xiong X,Wu D,Zhang G,Wang M,Dong S,Liu W,Yang H,Li Q

更新日期：2017-06-01 00:00:00