Abstract：
:Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to the nuclear DFS70 antigen that has rarely found in CTD. Serological testing for anti-DFS70 antibodies could therefore play a very interesting negative predictive role in stratifying patients on the basis of the evolution of UCTD to CTD. We described two patients ANA and anti-DFS70 positive in which the use of new method allowing the immunoadsorption of anti-DFS70 antibodies has permitted to exclude the incorrect diagnosis of CTD.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Infantino M,Meacci F,Grossi V,Manfredi M,Li Gobbi F,Sarzi-Puttini P,Atzeni F,Benucci Mdoi
10.1007/s12026-016-8836-4subject
Has Abstractpub_date
2017-02-01 00:00:00pages
293-295issue
1eissn
0257-277Xissn
1559-0755pii
10.1007/s12026-016-8836-4journal_volume
65pub_type
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