Abstract：
:In recent years, there has been a growing interest in the role of immune, alloimmune and autoimmune processes in the pathogenesis of spontaneous preterm birth and recurrent pregnancy loss. The association between an inflammatory response and preterm labor has been established. Indeed, many women suffering from preterm labor have elevated inflammatory markers such as tumor necrosis factor alpha, interleukin 6 and matrix metaloproeinase 8. The role of immune processes in the pathogenesis of recurrent pregnancy loss has also been widely researched. Progesterone induces many physiologic effects necessary for healthy pregnancy, and progestagens supplementation has been used as an approach to prevent preterm labor and recurrent pregnancy loss. Progestagens also have potent anti-inflammatory and immunomodulatory actions. Because preterm labor and recurrent pregnancy loss are associated with abnormal inflammation, progestagens may maintain healthy pregnancy through both endocrine and immunologic actions. These immunologic actions, such as suppression of Th1- and Th17-related responses, enhancement of regulatory T cell (Tregs) activity and suppression of inflammation, may also be involved in pregnancy-induced remission of certain autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS). Accordingly, there is growing interest in the potential therapeutic role of progestagens in the treatment of MS and RA. In this review, we suggest that biologic autoimmune modulators, especially those which affect immune pathways similar to progestagens, may provide more potent and specific effects, and hence better results than progestagens, in preventing preterm labor and recurrent pregnancy loss.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Tsur A,Hughes GC,Shoenfeld Y,Carp Hdoi
10.1007/s12026-014-8621-1subject
Has Abstractpub_date
2015-02-01 00:00:00pages
31-4issue
1-2eissn
0257-277Xissn
1559-0755journal_volume
61pub_type
杂志文章,评审abstract：:Diabetes is a chronic autoimmune disease that affects 4-5% of the world's population. If the present trends continue, diabetes would soon become a major/leading health problem worldwide. Hence there is an urgent need to develop novel approaches for the treatment of diabetes. While transplantation of the pancreas or th...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-007-0070-7
更新日期：2007-01-01 00:00:00
abstract：:The goal of our work is to understand, from the molecular to the organismal level, the principles that drive and sustain lifelong infection by viruses. These infectious agents live in a dynamic equilibrium (homeostasis) with their hosts in which both immune and nonimmune pathways contribute to viral homeostasis. Disru...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:21:2-3:219
更新日期：2000-01-01 00:00:00
abstract：:A complex interplay between pathogen and host determines the immune response during viral infection. A set of cytosolic sensors are expressed by immune cells to detect viral infection. NOD-like receptors (NLRs) comprise a large family of intracellular pattern recognition receptors. Members of the NLR family assemble i...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-016-8873-z
更新日期：2016-12-01 00:00:00
abstract：:Long noncoding RNAs (lncRNA) play key roles in regulating autoimmunity and immunity balance. LncRNA TMEVPG1, which is encoded by a gene located near the Ifn gene, contributes to interferon gamma expression. We investigated the expression of TMEVPG1 in patients with Sjögren syndrome (SS) to determine its role in the pa...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8715-4
更新日期：2016-04-01 00:00:00
abstract：:The human mayor histocompatibility complex class I molecule HLA-A2 preferentially binds peptides that contain Leu at P2 and Val or Leu at the C terminus. The other amino acids in the peptide also contribute to binding positively or negatively. It is possible to estimate the binding stability of HLA-A2 complexes contai...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02918496
更新日期：1995-01-01 00:00:00
abstract：:Interleukin-2 (IL-2), secreted principally by activated helper T-cells, plays a pivotal role in the generation and regulation of the immune response. The various biologic functions of IL-2 have been the focus of intensive study over the years and have been well worked out. By contrast, an understanding of the intracel...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786399
更新日期：1997-01-01 00:00:00
abstract：:We retrospectively analyzed the transplantation outcomes of 31 patients with primary immunodeficiency diseases treated at our center (All Children's Hospital, University of South Florida) since its inception in 1986. The primary immune diseases included severe combined immunodeficiency, Wiscott-Aldrich syndrome, X-lin...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-009-8111-z
更新日期：2009-01-01 00:00:00
abstract：:The etiology and immunologic states of autoimmune diseases have mainly been discussed without consideration of extrathymic T cells, which exist in the liver, intestine, and excretion glands. Because extrathymic T cells are autoreactive and are often simultaneously activated along with autoantibody-producing B-1 cells,...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:33:1:023
更新日期：2005-01-01 00:00:00
abstract：:The key role of T cells in hepatitis C virus (HCV) elimination and the ability of dendritic cells (DCs) to induce antiviral T cell responses suggest that DC vaccines could be a promising approach in the treatment of chronic HCV infection. The aim of our study was to evaluate, whether immunotherapy with DCs is safe and...
journal_title：Immunologic research
pub_type： 临床试验,杂志文章
doi：10.1007/s12026-017-8967-2
更新日期：2018-02-01 00:00:00
abstract：:Kv1.3 and IKCa1 lymphocyte potassium channels have been implicated as important targets of selective immunomodulation. We compared the alterations in cytokine production upon selective inhibition of Kv1.3 or IKCa1 channels (by MGTX and TRAM, respectively) in healthy donors (HD), RA and AS patients. We also determined ...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8683-8
更新日期：2016-04-01 00:00:00
abstract：:Major conceptual roadblocks impede the development of an HIV-1 vaccine that can stimulate a potent neutralizing antibody response. Animal models that support HIV-1 replication and allow for host genetic manipulation would be an ideal platform for testing various immunological hypotheses, but progress on this research ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8370-y
更新日期：2013-03-01 00:00:00
abstract：:The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-018-9004-9
更新日期：2018-06-01 00:00:00
abstract：:Activation-induced cell death (AICD) has been demonstrated in T-cell hybridomas, immature thymocytes, and activated mature T cells. However, the molecular mechanisms of AICD and its physiological role in T-helper-cell differentiation remain uncertain. Recently, we have shown that Th1 and Th2 cells have distinct mechan...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:28:3:285
更新日期：2003-01-01 00:00:00
abstract：:Thermal injury, as well as other forms of severe trauma, induces simultaneous hyper- and anti-inflammatory response. While data about decreased number and responsiveness of T lymphocytes are largely consistent, reports concerning granulocytes following trauma are contradictory. Contrary to the evidence on the increase...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-012-8280-z
更新日期：2012-04-01 00:00:00
abstract：:The aim of this study was to determine whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to Behcet's disease (BD). A meta-analysis was conducted, examining the associations between the IL-10 - 1082 G/A, - 819 C/T, and - 592 C/A polymorphisms and BD in various ethnic groups. Fourteen studi...
journal_title：Immunologic research
pub_type： 杂志文章,meta分析
doi：10.1007/s12026-019-09102-x
更新日期：2019-10-01 00:00:00
abstract：:Natural killer (NK) cells are effector cells of the innate immune system that can lyse target cells without prior sensitization and have an important role in host defense to pathogens and transformed cells. A balance between negative and positive signals transmitted via germ line-encoded inhibitory and activating rece...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8493-4
更新日期：2014-05-01 00:00:00
abstract：:Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work wil...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-007-0017-z
更新日期：2007-01-01 00:00:00
abstract：:The intestinal epithelium serves as one of human's primary interfaces with the outside world. This interface is very heavily colonized with bacteria and yet permits absorption of life-sustaining nutrients while protecting the tissues below from microbial onslaught. Although the gut epithelium had been classically thou...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:29:1-3:055
更新日期：2004-01-01 00:00:00
abstract：:Besides their well-characterized role as the initiator of adaptive immune responses, dendritic cells (DCs) play a critical role in the induction and maintenance of self-tolerance, the failure of which could lead to autoimmune/inflammatory diseases. Although it is clear that tolerance is a property of DCs at the steady...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8126-5
更新日期：2010-03-01 00:00:00
abstract：:The Cluster of differentiation 226(CD226)/T cell immunoglobulin and immune receptor tyrosine-based inhibitory motif domain (TIGIT) axis plays an important role in the balance of the immune response. A previous study showed that CD226 is involved in CD4+ T cell differentiation and that blocking CD226 may attenuate expe...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-019-09112-9
更新日期：2019-12-01 00:00:00
abstract：:Genes of the major histocompatibility complex (MHC) are one of the most significant genetic predictors of HIV and SIV disease outcome; however, in no case is MHC genotype alone sufficient to account for this durable HIV/SIV control. Killer immunoglobulin-like receptors (KIRs) interact with MHC molecules and have been ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-007-8010-0
更新日期：2008-01-01 00:00:00
abstract：:The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such are phosphorylcholine (PC) moieties which are a component of secreted products of helminths. PC has been broadl...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-018-9051-2
更新日期：2018-12-01 00:00:00
abstract：:The erbB family of receptor tyrosine kinases are growth factor receptors that are overexpressed or mutated in a large variety of human cancers. Studies of erbB-mediated signal transduction will lead to an understanding of the role played by this family of receptors in normal and transformed cells. In this article, we ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786443
更新日期：1998-01-01 00:00:00
abstract：:WASP, the product of the gene mutated in Wiskott-Aldrich syndrome, is expressed only in hematopoietic cells and is the archetype of a family of proteins that include N-WASP and Scar/WAVE. WASP plays a critical role in T cell activation and actin reorganization. WASP has multiple protein-interacting domains. Through it...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8086-1
更新日期：2009-01-01 00:00:00
abstract：:EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human host including ZEBRA (BZLF-1 encoded protein), BALF-2 recombinas...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-018-9045-0
更新日期：2018-12-01 00:00:00
abstract：:Our laboratory has studied the molecular basis of T helper cell differentiation. We have used reporter transgenic mice, selective hybridization techniques, and studies of cell signaling to show that a complex pattern of gene expression is reprogrammed as the decision is made to become either a Th1 or Th2 cell. Many of...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786484
更新日期：1999-01-01 00:00:00
abstract：:We have focused our research on understanding the basic biology of and developing novel therapeutic and prophylactic DNA vaccines. We have among others three distinct primary areas of interest which include: 1. Enhancing in vivo delivery and transfection of DNA vaccine vectors 2. Improving DNA vaccine construct immuno...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8076-3
更新日期：2008-01-01 00:00:00
abstract：:In performing host-defense functions, cells of the immune system become activated by soluble chemokine signals and must migrate through endothelial cell or solid tissue barriers to reach sites of inflammation or infection. Regulated adhesive interactions of immune cells with endothelium, extracellular matrix component...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:21:2-3:293
更新日期：2000-01-01 00:00:00
abstract：:The proteins of the tumor necrosis factor (TNF) receptor superfamily are a group of cell-surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. The ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:26:1-3:323
更新日期：2002-01-01 00:00:00
abstract：:Herpes simplex virus type 1 infection of the mouse eye results in an impressive inflammatory response culminating in the death of the animal or the establishment of a "latent" infection depending on a number of ill-defined variables that include components of the innate and adaptive immune system. The application of t...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1385/IR:30:2:191
更新日期：2004-01-01 00:00:00
