Abstract：
:The neonate has an increased susceptibility to infection, in part owing to an inability to produce antibody to thymus-independent antigens such as bacterial polysaccharides (PS). This poor response to PS antigens is likely owing to multiple factors. Neonatal B cells are of an immature phenotype, as evidenced by cell-surface marker characteristics and increased susceptibility to tolerance induction. The spleen of the neonate has a different cellular composition, which is most prominent in the marginal zone. Neonatal accessory cells such as macrophages and dendritic cells (DCs) appear to produce less stimulatory cytokines and an overabundance of inhibitory cytokines. This review examines the current data supporting the role of B cells and accessory cells in the neonatal unresponsiveness to PS antigens.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Landers CD,Chelvarajan RL,Bondada Sdoi
10.1385/IR:31:1:25subject
Has Abstractpub_date
2005-01-01 00:00:00pages
25-36issue
1eissn
0257-277Xissn
1559-0755pii
IR:31:1:25journal_volume
31pub_type
杂志文章,评审abstract：:The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such are phosphorylcholine (PC) moieties which are a component of secreted products of helminths. PC has been broadl...
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更新日期：2006-01-01 00:00:00
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