Abstract：
:Gender has long been known to be a contributory factor in the incidence and progression of disorders associated with immune system dysregulation. More recently, evidence has accumulated that gender may also play an important role in infectious disease susceptibility. In general, females generate more robust and potentially protective humoral and cell-mediated immune responses following antigenic challenge than their male counterparts. In contrast, males have frequently been observed to mount more aggressive and damaging inflammatory immune responses to microbial stimuli. In this article we review the evidence for sexual dimorphism in innate immune responses to infectious organisms and describe our recent studies that may provide a mechanism underlying gender-based differences in conditions such as bacterial sepsis.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Marriott I,Huet-Hudson YMdoi
10.1385/IR:34:3:177subject
Has Abstractpub_date
2006-01-01 00:00:00pages
177-92issue
3eissn
0257-277Xissn
1559-0755pii
IR:34:3:177journal_volume
34pub_type
杂志文章,评审abstract：:We examine whether B cell lines enriched for DNA specificity from either autoimmune (BWF1) or normal mice (Balb/c) can be rendered unresponsive to autoantigen in terms of the specific suppression of direct antibody-forming cells to DNA. These B cell lines were both Lyt-1 positive and negative. Preincubation with oligo...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/BF02935511
更新日期：1989-01-01 00:00:00
abstract：:An effective host response against viral infection of the central nervous system (CNS) is the principal factor dictating the outcome of infection. It is the responsibility of the immune response to contain and control viral replication. Paradoxically, it is the immune response that may also contribute to the developme...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:24:2:111
更新日期：2001-01-01 00:00:00
abstract：:A complex interplay between pathogen and host determines the immune response during viral infection. A set of cytosolic sensors are expressed by immune cells to detect viral infection. NOD-like receptors (NLRs) comprise a large family of intracellular pattern recognition receptors. Members of the NLR family assemble i...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-016-8873-z
更新日期：2016-12-01 00:00:00
abstract：:Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-016-8836-4
更新日期：2017-02-01 00:00:00
abstract：:The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-018-9004-9
更新日期：2018-06-01 00:00:00
abstract：:The examination of the immune T cell response to herpes simplex virus (HSV) antigen glycoprotein D (gD) in an ongoing infection has revealed a uniquely broad range of antigenic determinants seen. This has been shown in the murine T cell response to gD determinants where over 60% of the overlapping peptides are recogni...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786433
更新日期：1998-01-01 00:00:00
abstract：:Activation-induced cell death (AICD) has been demonstrated in T-cell hybridomas, immature thymocytes, and activated mature T cells. However, the molecular mechanisms of AICD and its physiological role in T-helper-cell differentiation remain uncertain. Recently, we have shown that Th1 and Th2 cells have distinct mechan...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:28:3:285
更新日期：2003-01-01 00:00:00
abstract：:This review of the events leading to the New Era of Immunology focuses on the important leads provided by the Experiments of Nature. Not only did they provide the path that led to our present knowledge of the ontogeny of the immune system, but also to an entirely new perspective of lymphocytic malignancies. The power ...
journal_title：Immunologic research
pub_type： 历史文章,杂志文章
doi：10.1007/s12026-007-0047-6
更新日期：2007-01-01 00:00:00
abstract：:Ethanol addition to B lymphocytes in vitro inhibits antigen-induced antibody secretion and antigen-induced cell proliferation. We tested the hypothesis that ethanol can inhibit the effect of interleukins on B-cell proliferation by adding ethanol to in vitro functional assays for IL-2 and IL-4. Ethanol does not inhibit...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/BF02918616
更新日期：1992-01-01 00:00:00
abstract：:We have focused our research on understanding the basic biology of and developing novel therapeutic and prophylactic DNA vaccines. We have among others three distinct primary areas of interest which include: 1. Enhancing in vivo delivery and transfection of DNA vaccine vectors 2. Improving DNA vaccine construct immuno...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8076-3
更新日期：2008-01-01 00:00:00
abstract：:The goal of our work is to understand, from the molecular to the organismal level, the principles that drive and sustain lifelong infection by viruses. These infectious agents live in a dynamic equilibrium (homeostasis) with their hosts in which both immune and nonimmune pathways contribute to viral homeostasis. Disru...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:21:2-3:219
更新日期：2000-01-01 00:00:00
abstract：:It is not unusual for antigens and potentially responsive T cells to co-exist in the same organism while these T cells remain silent and do not mount life-threatening immune responses. A rich array of mechanisms has been proposed to explain these observations. T cell silencing is controlled in multiple levels. Initial...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1385/IR:33:2:135
更新日期：2005-01-01 00:00:00
abstract：:The coexistence of alopecia areata (AA) and systemic lupus erythematosus (SLE) has been described, but the association between these conditions is yet to be firmly established. We aimed to evaluate the association between AA and SLE using a large-scale real-life computerized database. A cross-sectional study was condu...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-020-09115-x
更新日期：2020-02-01 00:00:00
abstract：:Aberrant T helper-2 (Th2) responses play a critical role in the pathogenesis of allergic diseases. The underlying mechanism is to be further investigated. It is reported that soluble CD83 (sCD83) has immune-regulatory effects. This study aims to investigate the role of sCD83 in the regulation of Th2 polarization. Bloo...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-020-09133-9
更新日期：2020-06-01 00:00:00
abstract：:Epidemiological studies have demonstrated an inverse correlation between prevalence of helminth infections and allergic diseases both associated to Th2 immune responses. On the other hand, such an inverse correlation has also been evidenced between allergies and bacterial infections, associated to Th1 responses. In th...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-007-0058-3
更新日期：2008-01-01 00:00:00
abstract：:Human leukocytes, including macrophages and neutrophils, are phagocytic immune cells that capture and engulf pathogens and subsequently destroy them in intracellular vesicles. To accomplish this vital task, these leukocytes utilize two basic cell behaviors-chemotaxis for chasing down infectious pathogens and phagocyto...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8056-7
更新日期：2009-01-01 00:00:00
abstract：:CD23, also known as the low affinity receptor for IgE (Fc epsilon RII), belongs to a novel superfamily of type-II integral membrane proteins. Fc epsilon RII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by severa...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02919132
更新日期：1992-01-01 00:00:00
abstract：:Immunological memory is a hallmark of adaptive immunity, a defense mechanism endowed to vertebrates during evolution. However, an autoimmune pathogenic role of memory lymphocytes is also emerging with accumulating evidence, despite reasonable skepticism on their existence in a chronic setting of autoimmune damage. It ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-013-8448-1
更新日期：2013-12-01 00:00:00
abstract：:Acute graft-versus-host disease (aGvHD) is still a major cause of transplant-related mortality after allogeneic stem cell transplantation (ASCT). It requires immunosuppressive treatments that broadly abrogate T cell responses including beneficial ones directed against tumor cells or infective pathogens. Polo-like kina...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8778-2
更新日期：2016-06-01 00:00:00
abstract：:The SH2 domain-containing inositol 5'-phosphatase (SHIP) negatively regulates antigen, cytokine, and Fc receptor signaling pathways in immune cells. Our knowledge of the function of SHIP largely derives from in vitro studies that utilized SHIP-deficient cell lines and immune cells isolated from SHIP null mice. To avoi...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-008-8078-1
更新日期：2009-01-01 00:00:00
abstract：:Previous studies showed that interleukin (IL)-28B gene polymorphisms were associated with hepatitis C Virus (HCV) infection and treatment outcomes. We tested whether single-nucleotide polymorphisms (SNPs) in IL-28A and IL-28B are associated with HCV infection among Egyptians with HCV genotype 4 infections. We enrolled...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-018-9035-2
更新日期：2019-02-01 00:00:00
abstract：:Studies on the biologic and molecular genetic underpinnings of multiple myeloma (MM) have identified the pleiotropic, pro-inflammatory cytokine, interleukin-6 (IL-6), as a factor crucial to the growth, proliferation and survival of myeloma cells. IL-6 is also a potent stimulator of osteoclastogenesis and a sculptor of...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8528-x
更新日期：2014-08-01 00:00:00
abstract：:Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE ...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-010-8175-9
更新日期：2011-04-01 00:00:00
abstract：:Previous studies by our group, using an experimental autoimmune thyroiditis (EAT) model in Strain 13 inbred guinea pigs, resulted in T cell-mediated delayed hypersensitivity; however, autoantibodies proved not to be cytotoxic to thyroid epithelial cells in the presence or absence of complement proteins. Albeit, T cell...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-011-8215-0
更新日期：2011-08-01 00:00:00
abstract：:In recent years, there has been a profound change in autoimmune diagnostics. From long, tiring and inaccurate manual methods, the art of diagnostics has turned to modern, rapid and automated technology. New antibody tests have been developed, and almost all autoimmune diseases now have some specific diagnostic markers...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-014-8587-z
更新日期：2015-02-01 00:00:00
abstract：:Besides their well-characterized role as the initiator of adaptive immune responses, dendritic cells (DCs) play a critical role in the induction and maintenance of self-tolerance, the failure of which could lead to autoimmune/inflammatory diseases. Although it is clear that tolerance is a property of DCs at the steady...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8126-5
更新日期：2010-03-01 00:00:00
abstract：:Cytolytic effector function fails to develop if proliferation of allospecific cytolytic T lymphocyte precursors is inhibited, but the requirements for generation of cytolytic activity have not been fully defined. In contrast, the cytolytic effector function of cytolytic T lymphocyte clones does not change during the c...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/BF02935614
更新日期：1994-01-01 00:00:00
abstract：:Staphylococcal exotoxins, staphylococcal enterotoxins A-E (SEA-SEE), and toxic shock syndrome toxin- (TSST-1) are potent activators of the immune system and cause a variety of diseases in humans, ranging from food poisoning to shock. These toxins are called superantigens because of their ability to polyclonally activa...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/BF02786471
更新日期：1999-01-01 00:00:00
abstract：:The follicular helper T cell (Tfh) and IL-21 have been shown to play an important role in many autoimmune diseases. However, less is known about their role in Graves' disease (GD). This study aimed to investigate the expression of Tfhs and related factors (IL-21, IL-21R, CXCR5, and CXCL13) in GD thyroid tissues and to...
journal_title：Immunologic research
pub_type： 杂志文章
doi：10.1007/s12026-015-8647-z
更新日期：2015-06-01 00:00:00
abstract：:Recent studies have elucidated unanticipated connections between the immune and skeletal systems, and this relationship has led to the development of a new field known as osteoimmunology. The goal of research in this field is to: (1) further understand how the bone microenvironment influences immune cell ontogeny and ...
journal_title：Immunologic research
pub_type： 杂志文章,评审
doi：10.1007/s12026-009-8093-x
更新日期：2009-12-01 00:00:00
