Abstract:
:Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that chemogenetic silencing of this reflex circuitry blocks post-SCI immune suppression. These data provide new insights and potential therapeutic options for limiting the devastating consequences of post-traumatic autonomic hyperreflexia and post-injury immune suppression.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Ueno M,Ueno-Nakamura Y,Niehaus J,Popovich PG,Yoshida Ydoi
10.1038/nn.4289subject
Has Abstractpub_date
2016-06-01 00:00:00pages
784-7issue
6eissn
1097-6256issn
1546-1726pii
nn.4289journal_volume
19pub_type
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