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Stimulus-specific enhancement of fear extinction during slow-wave sleep.

Abstract：

:Sleep can strengthen memory for emotional information, but whether emotional memories can be specifically targeted and modified during sleep is unknown. In human subjects who underwent olfactory contextual fear conditioning, re-exposure to the odorant context in slow-wave sleep promoted stimulus-specific fear extinction, with parallel reductions of hippocampal activity and reorganization of amygdala ensemble patterns. Thus, fear extinction may be selectively enhanced during sleep, even without re-exposure to the feared stimulus itself.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Hauner KK,Howard JD,Zelano C,Gottfried JA

doi

10.1038/nn.3527

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1553-5

issue

11

eissn

1097-6256

issn

1546-1726

pii

nn.3527

journal_volume

16

pub_type

杂志文章

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