Abstract:
:Distinct cell lineages established early in development are usually maintained throughout adulthood. Thus, adult stem cells have been thought to generate differentiated cells specific to the tissue in which they reside. This view has been challenged; for example, neural stem cells can generate cells that normally originate from a different germ layer. Here we show that acutely isolated and clonally derived neural stem cells from mice and humans could produce skeletal myotubes in vitro and in vivo, the latter following transplantation into adult animals. Myogenic conversion in vitro required direct exposure to myoblasts, and was blocked if neural cells were clustered. Thus, a community effect between neural cells may override such myogenic induction. We conclude that neural stem cells, which generate neurons, glia and blood cells, can also produce skeletal muscle cells, and can undergo various patterns of differentiation depending on exposure to appropriate epigenetic signals in mature tissues.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Galli R,Borello U,Gritti A,Minasi MG,Bjornson C,Coletta M,Mora M,De Angelis MG,Fiocco R,Cossu G,Vescovi ALdoi
10.1038/79924subject
Has Abstractpub_date
2000-10-01 00:00:00pages
986-91issue
10eissn
1097-6256issn
1546-1726journal_volume
3pub_type
杂志文章abstract::Many neural signaling receptors are regulated by endocytosis, but little is known about receptor insertion into the plasma membrane. Time-lapse imaging of the beta2 adrenergic receptor expressed in cultured rat hippocampal neurons, using pH-sensitive green fluorescent protein tagging and total internal reflection fluo...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1679
更新日期:2006-05-01 00:00:00
abstract::In the version of this article initially published, what was originally described as 'conditioned place preference' in a two-chamber mouse experiment could be better described as 'conditioned place avoidance'. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-018-0323-x
更新日期:2019-03-01 00:00:00
abstract::Nucleus HVc of the avian song system is a forebrain structure critical in song production, perception and learning. Here we show that most HVc neurons that respond to auditory stimuli under anesthesia show no responses to the same stimulus in the awake, unrestrained bird. This suppression of auditory responses in awak...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/2232
更新日期:1998-10-01 00:00:00
abstract::We demonstrate a form of long-term depression (LTD) in the perirhinal cortex that relies on interaction between different glutamate receptors. Group II metabotropic glutamate (mGlu) receptors facilitated group I mGlu receptor-mediated increases in intracellular calcium. This facilitation plus NMDA receptor activation ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/72093
更新日期:2000-02-01 00:00:00
abstract::Neurotransmitter transporters can affect neuronal excitability indirectly via modulation of neurotransmitter concentrations or directly via transporter currents. A physiological or pathophysiological role for transporter currents has not been described. We found that GABA transporter 1 (GAT-1) cation currents directly...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2940
更新日期:2011-10-30 00:00:00
abstract::A decade after speech was first decoded from human brain signals, accuracy and speed remain far below that of natural speech. Here we show how to decode the electrocorticogram with high accuracy and at natural-speech rates. Taking a cue from recent advances in machine translation, we train a recurrent neural network t...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-0608-8
更新日期:2020-04-01 00:00:00
abstract::Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promoted the physical i...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3207
更新日期:2012-10-01 00:00:00
abstract::The hippocampus is often considered to be an important site for stress and learning interactions; however, it has never been demonstrated whether these effects require the hippocampus. In the current study, hippocampal lesions prevented both enhancements of learning after stress in male rats and impairments of learnin...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1973
更新日期:2007-11-01 00:00:00
abstract::The brain transforms physical sensory stimuli into meaningful perceptions. In animals making choices about sensory stimuli, neuronal activity in successive cortical stages reflects a progression from sensation to decision. Feedforward and feedback pathways connecting cortical areas are critical for this transformation...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4356
更新日期:2016-09-01 00:00:00
abstract::Dopamine is vital for coordinated motion and for association learning linked to behavioral reinforcement. Here we show that the precise overlap of striatal dopaminergic and cholinergic fibers underlies potent control of dopamine release by ongoing nicotinic receptor activity. In mouse striatal slices, nicotinic antago...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn769
更新日期:2001-12-01 00:00:00
abstract::Active sensation requires the convergence of external stimuli with representations of body movements. We used mouse behavior, electrophysiology and optogenetics to dissect the temporal interactions among whisker movement, neural activity and sensation of touch. We photostimulated layer 4 activity in single barrels in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3419
更新日期:2013-07-01 00:00:00
abstract::Visual attention enhances the responses of visual neurons that encode the attended location. Several recent studies have shown that attention also decreases correlations between fluctuations in the responses of pairs of neurons (termed spike count correlation or r(SC)). These results are consistent with two hypotheses...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3835
更新日期:2014-11-01 00:00:00
abstract::As we move through the environment, the pattern of visual motion on the retina provides rich information about our movement through the scene. Human subjects can use this information, often termed "optic flow", to accurately estimate their direction of self movement (heading) from relatively sparse displays. Physiolog...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/259
更新日期:1998-05-01 00:00:00
abstract::Information analysis shows that face-selective neurons in inferior temporal cortex encode different stimulus attributes early and late in their response to the same image. ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/13149
更新日期:1999-10-01 00:00:00
abstract::We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wild-type mice. DSBs occurred in multiple brain regions, were most abundant in the dentate gyrus, which is involved in learning and memory, and were repaired within 24 h. Increasing neu...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3356
更新日期:2013-05-01 00:00:00
abstract::Timing is crucial to many aspects of human performance. To better understand its neural underpinnings, we used event-related fMRI to examine the time course of activation associated with different components of a time perception task. We distinguished systems associated with encoding time intervals from those related ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/85191
更新日期:2001-03-01 00:00:00
abstract::Neural activity exhibits complex dynamics related to various brain functions, internal states and behaviors. Understanding how neural dynamics explain specific measured behaviors requires dissociating behaviorally relevant and irrelevant dynamics, which is not achieved with current neural dynamic models as they are le...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-00733-0
更新日期:2021-01-01 00:00:00
abstract::Here we used magnetoencephalography (MEG) to investigate stages of processing in face perception in humans. We found a face-selective MEG response occurring only 100 ms after stimulus onset (the 'M100'), 70 ms earlier than previously reported. Further, the amplitude of this M100 response was correlated with successful...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn909
更新日期:2002-09-01 00:00:00
abstract::Accumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main pathology in affected neurons of people with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Morphological diversity and neuroanatomical distribution of pTDP-43 accumulations allowed classification of FTLD cases in...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0294-y
更新日期:2019-01-01 00:00:00
abstract::Ability to integrate diverse forms of information in current thought, or working memory, is essential for human reasoning and problem solving. We used functional imaging to identify brain regions preferentially involved in maintaining integrated versus unintegrated information in working memory. For equal amounts of v...
journal_title:Nature neuroscience
pub_type: 临床试验,杂志文章
doi:10.1038/71156
更新日期:2000-01-01 00:00:00
abstract::An unknown aspect of behavioral state regulation is how the circadian oscillator of the suprachiasmatic nucleus (SCN) regulates sleep and waking. In this report, we describe the necessary elements for a circuit that provides circadian regulation of arousal. Trans-synaptic retrograde tracing revealed a prominent indire...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/89522
更新日期:2001-07-01 00:00:00
abstract::Motor function requires that motor axons extend from the spinal cord at regular intervals and that they are myelinated by Schwann cells. Little attention has been given to another cellular structure, the perineurium, which ensheaths the motor nerve, forming a flexible, protective barrier. Consequently, the origin of p...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2025
更新日期:2008-02-01 00:00:00
abstract::Many attempts to obtain reliable self-administration behavior by laboratory animals with delta-9-tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, have been unsuccessful. Because self-administration behavior has been demonstrated in laboratory animals for almost all other psychoactive drugs abused ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/80577
更新日期:2000-11-01 00:00:00
abstract::The shift in ocular dominance induced by brief monocular deprivation is greatest during a postnatal critical period and is thought to decline irreversibly thereafter. However, here we demonstrate that complete visual deprivation through dark exposure restores rapid ocular dominance plasticity in adult rats. In additio...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1965
更新日期:2007-09-01 00:00:00
abstract::The cerebral cortex has the ability to adapt to altered sensory inputs. In the visual cortex, a small lesion to the retina causes the deprived cortical region to become responsive to adjacent parts of the visual field. This extensive topographic remapping is assumed to be mediated by the rewiring of intracortical conn...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2181
更新日期:2008-10-01 00:00:00
abstract::The efficiency of remyelination decreases with age, but the molecular mechanisms responsible for this decline remain only partially understood. In this study, we show that remyelination is regulated by age-dependent epigenetic control of gene expression. In demyelinated young brains, new myelin synthesis is preceded b...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2172
更新日期:2008-09-01 00:00:00
abstract::Dendritic spines are motile structures that contain high concentrations of filamentous actin. Using hippocampal neurons expressing fluorescent actin and the method of fluorescence recovery after photobleaching, we found that 85 +/- 2% of actin in the spine was dynamic, with a turnover time of 44.2 +/- 4.0 s. The rapid...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn811
更新日期:2002-03-01 00:00:00
abstract::Spillover of glutamate under physiological conditions has only been established as an adjunct to conventional synaptic transmission. Here we describe a pure spillover connection between the climbing fiber and molecular layer interneurons in the rat cerebellar cortex. We show that, instead of acting via conventional sy...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1907
更新日期:2007-06-01 00:00:00
abstract::The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine neurons of mice. Consequently, a stimulation protocol pairing glutamate release with hy...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2763
更新日期:2011-04-01 00:00:00
abstract::Central pattern generators (CPGs) are spinal neuronal networks required for locomotion. Glutamatergic neurons have been implicated as being important for intrinsic rhythm generation in the CPG and for the command signal for initiating locomotion, although this has not been demonstrated directly. We used a newly genera...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2482
更新日期:2010-02-01 00:00:00