Abstract：
:We examined enhancement of synaptic transmission by neurotrophins at the presynaptic level. In a synaptosomal preparation, brain-derived neurotrophic factor (BDNF) increased mitogen-activated protein (MAP) kinase-dependent synapsin I phosphorylation and acutely facilitated evoked glutamate release. PD98059, used to inhibit MAP kinase activity, markedly decreased synapsin I phosphorylation and concomitantly reduced neurotransmitter release. The stimulation of glutamate release by BDNF was strongly attenuated in mice lacking synapsin I and/or synapsin II. These results indicate a causal link of synapsin phosphorylation via BDNF, TrkB receptors and MAP kinase with downstream facilitation of neurotransmitter release.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Jovanovic JN,Czernik AJ,Fienberg AA,Greengard P,Sihra TSdoi
10.1038/73888subject
Has Abstractpub_date
2000-04-01 00:00:00pages
323-9issue
4eissn
1097-6256issn
1546-1726journal_volume
3pub_type
杂志文章abstract：:Emotions operate along the dimension of approach and aversion, and it is reasonable to assume that orienting behavior is intrinsically linked to emotionally involved processes such as preference decisions. Here we describe a gaze 'cascade effect' that was present when human observers were shown pairs of human faces an...
journal_title：Nature neuroscience
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abstract：:The distinct electrical properties of axonal and dendritic membranes are largely a result of specific transport of vesicle-bound membrane proteins to each compartment. How this specificity arises is unclear because kinesin motors that transport vesicles cannot autonomously distinguish dendritically projecting microtub...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2318
更新日期：2009-05-01 00:00:00
abstract：:Human neurodegenerative disorders are among the most difficult to study. In particular, the inability to readily obtain the faulty cell types most relevant to these diseases has impeded progress for decades. Recent advances in pluripotent stem cell technology now grant access to substantial quantities of disease-perti...
journal_title：Nature neuroscience
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abstract：:Exposures to cocaine and morphine produce similar adaptations in nucleus accumbens (NAc)-based behaviors, yet produce very different adaptations at NAc excitatory synapses. In an effort to explain this paradox, we found that both drugs induced NMDA receptor-containing, AMPA receptor-silent excitatory synapses, albeit ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4313
更新日期：2016-07-01 00:00:00
abstract：:Quantifying behavior is crucial for many applications in neuroscience. Videography provides easy methods for the observation and recording of animal behavior in diverse settings, yet extracting particular aspects of a behavior for further analysis can be highly time consuming. In motor control studies, humans or other...
journal_title：Nature neuroscience
pub_type： 杂志文章
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abstract：:In vivo model systems are a critical tool for gaining insight into the pathology underlying psychiatric disorders. Although modern functional imaging tools allow study of brain correlates of behavior in clinical groups and genome-wide association studies are beginning to uncover the complex genetic architecture of psy...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
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更新日期：2016-11-01 00:00:00
abstract：:Uncovering structural regularities and architectural topologies of cortical circuitry is vital for understanding neural computations. Recently, an experimentally constrained algorithm generated a dense network reconstruction of a ∼0.3-mm3 volume from juvenile rat somatosensory neocortex, comprising ∼31,000 cells and ∼...
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abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease whose causes are still poorly understood. To identify additional genetic risk factors, we assessed the role of de novo mutations in ALS by sequencing the exomes of 47 ALS patients and both of their unaffected parents (n = 141 exomes). We fo...
journal_title：Nature neuroscience
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pub_type： 杂志文章
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更新日期：2004-09-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2011-01-01 00:00:00
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