abstract：:Neural-derived signals are crucial regulators of CNS vascularization. However, whether the vasculature responds to these signals by means of elongating and branching or in addition by building a feedback response to modulate neurodevelopmental processes remains unknown. In this study, we identified bidirectional cross...

journal_title：Nature neuroscience

authors： Paredes I,Vieira JR,Shah B,Ramunno CF,Dyckow J,Adler H,Richter M,Schermann G,Giannakouri E,Schirmer L,Augustin HG,Ruiz de Almodóvar C

更新日期：2021-01-28 00:00:00

abstract：:GABA interneurons play a critical role in higher brain functions. Astrocytic glial cells interact with synapses throughout the whole brain and are recognized as regulatory elements of excitatory synaptic transmission. However, it is largely unknown how GABAergic interneurons and astrocytes interact and contribute to s...

journal_title：Nature neuroscience

authors： Mederos S,Sánchez-Puelles C,Esparza J,Valero M,Ponomarenko A,Perea G

更新日期：2021-01-01 00:00:00

abstract：:Sensory pathways are typically studied by starting at receptor neurons and following postsynaptic neurons into the brain. However, this leads to a bias in analyses of activity toward the earliest layers of processing. Here, we present new methods for volumetric neural imaging with precise across-brain registration to ...

journal_title：Nature neuroscience

authors： Pacheco DA,Thiberge SY,Pnevmatikakis E,Murthy M

更新日期：2021-01-01 00:00:00

abstract：:Neural activity exhibits complex dynamics related to various brain functions, internal states and behaviors. Understanding how neural dynamics explain specific measured behaviors requires dissociating behaviorally relevant and irrelevant dynamics, which is not achieved with current neural dynamic models as they are le...

journal_title：Nature neuroscience

authors： Sani OG,Abbaspourazad H,Wong YT,Pesaran B,Shanechi MM

更新日期：2021-01-01 00:00:00

abstract：:Successfully navigating in physical or semantic space requires a neural representation of allocentric (map-based) vectors to boundaries, objects and goals. Cognitive processes such as path-planning and imagination entail the recall of vector representations, but evidence of neuron-level memory for allocentric vectors ...

journal_title：Nature neuroscience

authors： Poulter S,Lee SA,Dachtler J,Wills TJ,Lever C

更新日期：2020-12-21 00:00:00

abstract：:Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors incl...

journal_title：Nature neuroscience

authors： Lischinsky JE,Lin D

更新日期：2020-11-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Keysers C,Gazzola V,Wagenmakers EJ

更新日期：2020-11-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Rothschild G,Nelken I,Mizrahi A

更新日期：2020-11-01 00:00:00

abstract：:The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical ...

journal_title：Nature neuroscience

authors： Takahashi N,Ebner C,Sigl-Glöckner J,Moberg S,Nierwetberg S,Larkum ME

更新日期：2020-10-01 00:00:00

abstract：:Axon degeneration is a hallmark of many neurodegenerative disorders. The current assumption is that the decision of injured axons to degenerate is cell-autonomously regulated. Here we show that Schwann cells (SCs), the glia of the peripheral nervous system, protect injured axons by virtue of a dramatic glycolytic upre...

journal_title：Nature neuroscience

authors： Babetto E,Wong KM,Beirowski B

更新日期：2020-10-01 00:00:00

abstract：:Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a leading cause of disability for almost three decades. Past molecular studies of MDD employed bulk homogenates of postmortem brain tissue, which obscures gene expression changes withi...

journal_title：Nature neuroscience

authors： Nagy C,Maitra M,Tanti A,Suderman M,Théroux JF,Davoli MA,Perlman K,Yerko V,Wang YC,Tripathy SJ,Pavlidis P,Mechawar N,Ragoussis J,Turecki G

更新日期：2020-06-01 00:00:00

abstract：:Social behaviors recruit multiple cognitive operations that require interactions between cortical and subcortical brain regions. Interareal synchrony may facilitate such interactions between cortical and subcortical neural populations. However, it remains unknown how neurons from different nodes in the social brain ne...

journal_title：Nature neuroscience

authors： Dal Monte O,Chu CCJ,Fagan NA,Chang SWC

更新日期：2020-04-01 00:00:00

abstract：:A decade after speech was first decoded from human brain signals, accuracy and speed remain far below that of natural speech. Here we show how to decode the electrocorticogram with high accuracy and at natural-speech rates. Taking a cue from recent advances in machine translation, we train a recurrent neural network t...

journal_title：Nature neuroscience

authors： Makin JG,Moses DA,Chang EF

更新日期：2020-04-01 00:00:00

abstract：:Communication plays an integral role in human social dynamics and is impaired in several neurodevelopmental disorders. Mice are used to study the neurobiology of social behavior; however, the extent to which mouse vocalizations influence social dynamics has remained elusive because it is difficult to identify the voca...

journal_title：Nature neuroscience

authors： Sangiamo DT,Warren MR,Neunuebel JP

更新日期：2020-03-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is genetically heterogeneous with convergent symptomatology, suggesting common dysregulated pathways. In this study, we analyzed brain transcriptional changes in five mouse models of Pitt-Hopkins syndrome (PTHS), a syndromic form of ASD caused by mutations in the TCF4 gene, but not the T...

journal_title：Nature neuroscience

authors： Phan BN,Bohlen JF,Davis BA,Ye Z,Chen HY,Mayfield B,Sripathy SR,Cerceo Page S,Campbell MN,Smith HL,Gallop D,Kim H,Thaxton CL,Simon JM,Burke EE,Shin JH,Kennedy AJ,Sweatt JD,Philpot BD,Jaffe AE,Maher BJ

更新日期：2020-03-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Farhan SMK,Howrigan DP,Abbott LE,Klim JR,Topp SD,Byrnes AE,Churchhouse C,Phatnani H,Smith BN,Rampersaud E,Wu G,Wuu J,Shatunov A,Iacoangeli A,Khleifat AA,Mordes DA,Ghosh S,ALSGENS Consortium.,FALS Consortium.,Project

更新日期：2020-02-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Marschallinger J,Iram T,Zardeneta M,Lee SE,Lehallier B,Haney MS,Pluvinage JV,Mathur V,Hahn O,Morgens DW,Kim J,Tevini J,Felder TK,Wolinski H,Bertozzi CR,Bassik MC,Aigner L,Wyss-Coray T

更新日期：2020-02-01 00:00:00

abstract：:Protein-coding de novo mutations (DNMs) are significant risk factors in many neurodevelopmental disorders, whereas schizophrenia (SCZ) risk associated with DNMs has thus far been shown to be modest. We analyzed DNMs from 1,695 SCZ-affected trios and 1,077 published SCZ-affected trios to better understand the contribut...

journal_title：Nature neuroscience

authors： Howrigan DP,Rose SA,Samocha KE,Fromer M,Cerrato F,Chen WJ,Churchhouse C,Chambert K,Chandler SD,Daly MJ,Dumont A,Genovese G,Hwu HG,Laird N,Kosmicki JA,Moran JL,Roe C,Singh T,Wang SH,Faraone SV,Glatt SJ,McCarroll

更新日期：2020-02-01 00:00:00

abstract：:To discover novel genes underlying amyotrophic lateral sclerosis (ALS), we aggregated exomes from 3,864 cases and 7,839 ancestry-matched controls. We observed a significant excess of rare protein-truncating variants among ALS cases, and these variants were concentrated in constrained genes. Through gene level analyses...

journal_title：Nature neuroscience

authors： Farhan SMK,Howrigan DP,Abbott LE,Klim JR,Topp SD,Byrnes AE,Churchhouse C,Phatnani H,Smith BN,Rampersaud E,Wu G,Wuu J,Shatunov A,Iacoangeli A,Al Khleifat A,Mordes DA,Ghosh S,ALSGENS Consortium.,FALS Consortium.,Proje

更新日期：2019-12-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Mongillo G,Rumpel S,Loewenstein Y

更新日期：2019-12-01 00:00:00

abstract：:Axonal injury results in regenerative success or failure, depending on whether the axon lies in the peripheral or the CNS, respectively. The present study addresses whether epigenetic signatures in dorsal root ganglia discriminate between regenerative and non-regenerative axonal injury. Chromatin immunoprecipitation f...

journal_title：Nature neuroscience

authors： Palmisano I,Danzi MC,Hutson TH,Zhou L,McLachlan E,Serger E,Shkura K,Srivastava PK,Hervera A,Neill NO,Liu T,Dhrif H,Wang Z,Kubat M,Wuchty S,Merkenschlager M,Levi L,Elliott E,Bixby JL,Lemmon VP,Di Giovanni S

更新日期：2019-11-01 00:00:00

abstract：:Psychiatric morbidity is high in cities, so identifying potential modifiable urban protective factors is important. We show that exposure to urban green space improves well-being in naturally behaving male and female city dwellers, particularly in districts with higher psychiatric incidence and fewer green resources. ...

journal_title：Nature neuroscience

authors： Tost H,Reichert M,Braun U,Reinhard I,Peters R,Lautenbach S,Hoell A,Schwarz E,Ebner-Priemer U,Zipf A,Meyer-Lindenberg A

更新日期：2019-09-01 00:00:00

abstract：:Understanding the transcriptional changes that are engaged in stress resilience may reveal novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing data from brains of resilient mice to identify a gene network that is unique to resilience. Zfp189, which encodes a previously unstudied zin...

journal_title：Nature neuroscience

authors： Lorsch ZS,Hamilton PJ,Ramakrishnan A,Parise EM,Salery M,Wright WJ,Lepack AE,Mews P,Issler O,McKenzie A,Zhou X,Parise LF,Pirpinias ST,Ortiz Torres I,Kronman HG,Montgomery SE,Loh YE,Labonté B,Conkey A,Symonds AE,Nev

更新日期：2019-09-01 00:00:00

abstract：:T cells clear virus from the CNS and dynamically regulate brain functions, including spatial learning, through cytokine signaling. Here we determined whether hippocampal T cells that persist after recovery from infection with West Nile virus (WNV) or Zika virus (ZIKV) impact hippocampal-dependent learning and memory. ...

journal_title：Nature neuroscience

authors： Garber C,Soung A,Vollmer LL,Kanmogne M,Last A,Brown J,Klein RS

更新日期：2019-08-01 00:00:00

abstract：:The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer's disease (AD). Alternative APP processing via the metalloprotease ADAM10 prevents amyloid-β formation. We tested wh...

journal_title：Nature neuroscience

authors： Esteve P,Rueda-Carrasco J,Inés Mateo M,Martin-Bermejo MJ,Draffin J,Pereyra G,Sandonís Á,Crespo I,Moreno I,Aso E,Garcia-Esparcia P,Gomez-Tortosa E,Rábano A,Fortea J,Alcolea D,Lleo A,Heneka MT,Valpuesta JM,Esteban JA,

更新日期：2019-08-01 00:00:00

abstract：:Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong genetic component, with twin heritability estimates ranging from 51 to 70%. Here we performed a genome-wide association study of CUD in 2,387 ca...

journal_title：Nature neuroscience

authors： Demontis D,Rajagopal VM,Thorgeirsson TE,Als TD,Grove J,Leppälä K,Gudbjartsson DF,Pallesen J,Hjorthøj C,Reginsson GW,Tyrfingsson T,Runarsdottir V,Qvist P,Christensen JH,Bybjerg-Grauholm J,Bækvad-Hansen M,Huckins LM,Stahl

更新日期：2019-07-01 00:00:00

abstract：:Predatory hunting plays a fundamental role in animal survival. Little is known about the neural circuits that convert sensory cues into neural signals to drive this behavior. Here we identified an excitatory subcortical neural circuit from the superior colliculus to the zona incerta that triggers predatory hunting. Th...

journal_title：Nature neuroscience

authors： Shang C,Liu A,Li D,Xie Z,Chen Z,Huang M,Li Y,Wang Y,Shen WL,Cao P

更新日期：2019-06-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produced by glioblastoma cells activates aryl hydrocarbon receptor (AHR) in...

journal_title：Nature neuroscience

authors： Takenaka MC,Gabriely G,Rothhammer V,Mascanfroni ID,Wheeler MA,Chao CC,Gutiérrez-Vázquez C,Kenison J,Tjon EC,Barroso A,Vandeventer T,de Lima KA,Rothweiler S,Mayo L,Ghannam S,Zandee S,Healy L,Sherr D,Farez MF,Prat A,

更新日期：2019-05-01 00:00:00

abstract：:Striatal parvalbumin (PV) and cholinergic interneurons (CHIs) are poised to play major roles in behavior by coordinating the networks of medium spiny cells that relay motor output. However, the small numbers and scattered distribution of these cells have hindered direct assessment of their contribution to activity in ...

journal_title：Nature neuroscience

authors： Gritton HJ,Howe WM,Romano MF,DiFeliceantonio AG,Kramer MA,Saligrama V,Bucklin ME,Zemel D,Han X

更新日期：2019-04-01 00:00:00

abstract：:We introduce a deceptively simple behavioral task that robustly identifies two qualitatively different groups within the general population. When presented with an isochronous train of random syllables, some listeners are compelled to align their own concurrent syllable production with the perceived rate, whereas othe...

journal_title：Nature neuroscience

authors： Assaneo MF,Ripollés P,Orpella J,Lin WM,de Diego-Balaguer R,Poeppel D

更新日期：2019-04-01 00:00:00

abstract：:By combining computational, morphological, and functional analyses, this study relates latent markers of associative threat learning to overt post-traumatic stress disorder (PTSD) symptoms in combat veterans. Using reversal learning, we found that symptomatic veterans showed greater physiological adjustment to cues th...

journal_title：Nature neuroscience

authors： Homan P,Levy I,Feltham E,Gordon C,Hu J,Li J,Pietrzak RH,Southwick S,Krystal JH,Harpaz-Rotem I,Schiller D

更新日期：2019-03-01 00:00:00

abstract：:In the version of this article initially published, what was originally described as 'conditioned place preference' in a two-chamber mouse experiment could be better described as 'conditioned place avoidance'. ...

journal_title：Nature neuroscience

authors： Chen G,Kim YH,Li H,Luo H,Liu DL,Zhang ZJ,Lay M,Chang W,Zhang YQ,Ji RR

更新日期：2019-03-01 00:00:00

abstract：:UTX is a chromatin modifier required for development and neural lineage specification, but how it controls these biological processes is unclear. To determine the molecular mechanisms of UTX, we identified novel UTX protein interaction partners. Here we show that UTX and 53BP1 directly interact and co-occupy promoters...

journal_title：Nature neuroscience

authors： Yang X,Xu B,Mulvey B,Evans M,Jordan S,Wang YD,Pagala V,Peng J,Fan Y,Patel A,Peng JC

更新日期：2019-03-01 00:00:00

abstract：:In higher sensory cortices, there is a gradual transformation from sensation to perception and action. In the auditory system, this transformation is revealed by responses in the rostral ventral posterior auditory field (VPr), a tertiary area in the ferret auditory cortex, which shows long-term learning in trained com...

journal_title：Nature neuroscience

authors： Elgueda D,Duque D,Radtke-Schuller S,Yin P,David SV,Shamma SA,Fritz JB

更新日期：2019-03-01 00:00:00

abstract：:Transcriptomic analyses of postmortem brains have begun to elucidate molecular abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in synaptic development, RNA editing, has not yet been studied on a genome-wide scale. Here we profiled global patterns of adenosine-to-inosine (A-to-I) ed...

journal_title：Nature neuroscience

authors： Tran SS,Jun HI,Bahn JH,Azghadi A,Ramaswami G,Van Nostrand EL,Nguyen TB,Hsiao YE,Lee C,Pratt GA,Martínez-Cerdeño V,Hagerman RJ,Yeo GW,Geschwind DH,Xiao X

更新日期：2019-01-01 00:00:00

abstract：:Accumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main pathology in affected neurons of people with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Morphological diversity and neuroanatomical distribution of pTDP-43 accumulations allowed classification of FTLD cases in...

journal_title：Nature neuroscience

authors： Laferrière F,Maniecka Z,Pérez-Berlanga M,Hruska-Plochan M,Gilhespy L,Hock EM,Wagner U,Afroz T,Boersema PJ,Barmettler G,Foti SC,Asi YT,Isaacs AM,Al-Amoudi A,Lewis A,Stahlberg H,Ravits J,De Giorgi F,Ichas F,Bezard E,

更新日期：2019-01-01 00:00:00

abstract：:Animals strategically scan the environment to form an accurate perception of their surroundings. Here we investigated the neuronal representations that mediate this behavior. Ca2+ imaging and selective optogenetic manipulation during an active sensing task reveals that layer 5 pyramidal neurons in the vibrissae cortex...

journal_title：Nature neuroscience

authors： Ranganathan GN,Apostolides PF,Harnett MT,Xu NL,Druckmann S,Magee JC

更新日期：2018-11-01 00:00:00

abstract：:Humans and other primates sample the visual environment using saccadic eye movements that shift a high-resolution fovea toward regions of interest to create a clear perception of a scene across fixations. Many mammals, however, like mice, lack a fovea, which raises the question of why they make saccades. Here we descr...

journal_title：Nature neuroscience

authors： Samonds JM,Geisler WS,Priebe NJ

更新日期：2018-11-01 00:00:00

abstract：:A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and brain damage. Despite the involvement of distinct proteins in different NDs, the process of protein misfolding and aggregation is remarka...

journal_title：Nature neuroscience

authors： Soto C,Pritzkow S

更新日期：2018-10-01 00:00:00

abstract：:Nature Neuroscience presents a special issue of recent advances on shared mechanisms underlying neurodegenerative disease. ...

journal_title：Nature neuroscience

authors：

更新日期：2018-10-01 00:00:00