Abstract:
:A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify the intrinsic excitability of neuron B51, a critical element for the expression of the feeding response, thus revealing that these two forms of associative learning differ at the cellular level.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Lorenzetti FD,Mozzachiodi R,Baxter DA,Byrne JHdoi
10.1038/nn1593subject
Has Abstractpub_date
2006-01-01 00:00:00pages
17-9issue
1eissn
1097-6256issn
1546-1726pii
nn1593journal_volume
9pub_type
杂志文章abstract::Retinal bipolar cells have been assumed to generate purely graded responses to light. To test this idea we imaged the presynaptic calcium transient in live zebrafish. We found that ON, OFF, transient and sustained bipolar cells are all capable of generating fast 'all-or-none' calcium transients modulated by visual sti...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2841
更新日期:2011-06-26 00:00:00
abstract::Previous work has shown that human adolescents may be hypersensitive to rewards, but it is not known which aspect of reward processing is responsible for this. We separated decision value and prediction error signals and found that neural prediction error signals in the striatum peaked in adolescence, whereas neural d...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2558
更新日期:2010-06-01 00:00:00
abstract::Neural-derived signals are crucial regulators of CNS vascularization. However, whether the vasculature responds to these signals by means of elongating and branching or in addition by building a feedback response to modulate neurodevelopmental processes remains unknown. In this study, we identified bidirectional cross...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-00788-z
更新日期:2021-01-28 00:00:00
abstract::Neuronal development, plasticity and survival require activity-dependent synapse-to-nucleus signaling. Most studies implicate an activity-dependent regulation of gene expression in this phenomenon. However, little is known about other nuclear functions that are regulated by synaptic activity. Here we show that a newly...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1867
更新日期:2007-04-01 00:00:00
abstract::The music faculty is not a monolithic entity that a person either has or does not. Rather, it comprises a set of neurally isolable processing components, each having the potential to be specialized for music. Here we propose a functional architecture for music processing that captures the typical properties of modular...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn1083
更新日期:2003-07-01 00:00:00
abstract::Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in the neurovascular unit between endothelial cells, astrocytes and neurons. This position allows them to regulate key neurovascular functions of the brain. The role of pericytes in the regulation of cerebral blood flow (CBF) an...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4489
更新日期:2017-03-01 00:00:00
abstract::The zona limitans intrathalamica (ZLI), a narrow compartment in the vertebrate forebrain that bisects the diencephalon transversely, expresses the secreted factor sonic hedgehog (Shh). Because genetic disruption of Shh in mouse causes severe early developmental defects, this strategy has not been useful in identifying...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1338
更新日期:2004-11-01 00:00:00
abstract::Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subunit IIβ (PKARIIβ). A lack...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3636
更新日期:2014-03-01 00:00:00
abstract::Epilepsy is a common and refractory neurological disorder, but the neuronal regulatory mechanisms of epileptogenesis remain largely unclear. Activity-dependent transcription of genes for neurotrophins such as brain-derived neurotrophic factor (BDNF) has been shown to promote epileptogenesis; however, little is known a...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3005
更新日期:2011-12-11 00:00:00
abstract::Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3625
更新日期:2014-02-01 00:00:00
abstract::The molecular mechanisms that activate morphogenesis of cerebral cortex are currently the subject of intensive experimental analysis. Transcription factor genes of the homeobox, basic helix-loop-helix (bHLH) and zinc-finger families have recently been shown to have essential roles in this process. However, the actual ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn892
更新日期:2002-08-01 00:00:00
abstract::Synaptic cadherin adhesion complexes are known to be key regulators of synapse plasticity. However, the molecular mechanisms that coordinate activity-induced modifications in cadherin localization and adhesion and the subsequent changes in synapse morphology and efficacy remain unknown. We demonstrate that the intrace...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3657
更新日期:2014-04-01 00:00:00
abstract::Polyamines are endogenous molecules involved in cell damage following neurological insults, although it is unclear whether polyamines reduce or exacerbate this damage. We used a developmental seizure model in which we exposed Xenopus laevis tadpoles to pentylenetetrazole (PTZ), a known convulsant. We found that, after...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2777
更新日期:2011-04-01 00:00:00
abstract::The cerebral cortex has the ability to adapt to altered sensory inputs. In the visual cortex, a small lesion to the retina causes the deprived cortical region to become responsive to adjacent parts of the visual field. This extensive topographic remapping is assumed to be mediated by the rewiring of intracortical conn...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2181
更新日期:2008-10-01 00:00:00
abstract::Basal dendrites receive the majority of synapses that contact neocortical pyramidal neurons, yet our knowledge of synaptic processing in these dendrites has been hampered by their inaccessibility for electrical recordings. A new approach to patch-clamp recordings enabled us to characterize the integrative properties o...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1826
更新日期:2007-02-01 00:00:00
abstract::As we move through the environment, the pattern of visual motion on the retina provides rich information about our movement through the scene. Human subjects can use this information, often termed "optic flow", to accurately estimate their direction of self movement (heading) from relatively sparse displays. Physiolog...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/259
更新日期:1998-05-01 00:00:00
abstract::Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial re...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2751
更新日期:2011-03-01 00:00:00
abstract::Uncovering the functional relationship between temporal lobe amnesia and diencephalic amnesia depends on determining the role of the fornix, the major interlinking fiber tract. In this study relating fornix volume with memory, we made magnetic resonance imaging-based volume estimates of 13 brain structures in 38 indiv...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2149
更新日期:2008-07-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease whose causes are still poorly understood. To identify additional genetic risk factors, we assessed the role of de novo mutations in ALS by sequencing the exomes of 47 ALS patients and both of their unaffected parents (n = 141 exomes). We fo...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3412
更新日期:2013-07-01 00:00:00
abstract::The contribution of basal ganglia outputs to consummatory behavior remains poorly understood. We recorded from the substantia nigra pars reticulata (SNR), the major basal ganglia output nucleus, during self-initiated drinking in mice. The firing rates of many lateral SNR neurons were time-locked to individual licks. T...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4285
更新日期:2016-05-01 00:00:00
abstract::To investigate how the brain combines knowledge with visual processing to locate eye movement targets, we trained monkeys to search for a target defined by a conjunction of color and shape. On successful trials, neurons in the frontal eye field not only discriminated the target from distractors, but also discriminated...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/9205
更新日期:1999-06-01 00:00:00
abstract::Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) of Flag-tagged-H1.0 in mouse forebrain excitatory neurons. Unexpectedly, Flag-H1.0 and MeCP2 occupied similar geno...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0155-8
更新日期:2018-06-01 00:00:00
abstract::We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, wher...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1921
更新日期:2007-07-01 00:00:00
abstract::Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development,...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3604
更新日期:2014-03-01 00:00:00
abstract::The spinal cord is the initial stage that integrates temperature information from peripheral inputs. Here we used molecular genetics and in vivo calcium imaging to investigate the coding of cutaneous temperature in the spinal cord in mice. We found that heating or cooling the skin evoked robust calcium responses in sp...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4350
更新日期:2016-09-01 00:00:00
abstract::Unifying principles of movement have emerged from the computational study of motor control. We review several of these principles and show how they apply to processes such as motor planning, control, estimation, prediction and learning. Our goal is to demonstrate how specific models emerging from the computational app...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/81497
更新日期:2000-11-01 00:00:00
abstract::Fear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to induce synaptic plasti...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3491
更新日期:2013-10-01 00:00:00
abstract::The olfactory system faces a hard problem: on the basis of noisy information from olfactory receptor neurons (the neurons that transduce chemicals to neural activity), it must figure out which odors are present in the world. Odors almost never occur in isolation, and different odors excite overlapping populations of o...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4444
更新日期:2017-01-01 00:00:00
abstract::Odor stimulation evokes complex spatiotemporal activity in the olfactory bulb, suggesting that both the identity of activated neurons and the timing of their activity convey information about odors. However, whether and how downstream neurons decipher these temporal patterns remains unknown. We addressed this question...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3407
更新日期:2013-07-01 00:00:00
abstract::Agonists of GABA(B) receptors exert a bi-directional effect on the activity of dopamine (DA) neurons of the ventral tegmental area, which can be explained by the fact that coupling between GABA(B) receptors and G protein-gated inwardly rectifying potassium (GIRK) channels is significantly weaker in DA neurons than in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2006
更新日期:2007-12-01 00:00:00