Abstract:
:Retinal bipolar cells have been assumed to generate purely graded responses to light. To test this idea we imaged the presynaptic calcium transient in live zebrafish. We found that ON, OFF, transient and sustained bipolar cells are all capable of generating fast 'all-or-none' calcium transients modulated by visual stimulation.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Dreosti E,Esposti F,Baden T,Lagnado Ldoi
10.1038/nn.2841subject
Has Abstractpub_date
2011-06-26 00:00:00pages
951-2issue
8eissn
1097-6256issn
1546-1726pii
nn.2841journal_volume
14pub_type
杂志文章abstract::The amygdala is essential for fear learning and expression. The central amygdala (CeA), once viewed as a passive relay between the amygdala complex and downstream fear effectors, has emerged as an active participant in fear conditioning. However, the mechanism by which CeA contributes to the learning and expression of...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3322
更新日期:2013-03-01 00:00:00
abstract::Neuroimaging studies show that the efficacy of long-term memory encoding of a stimulus is indexed by transient neural activity elicited by that stimulus. Here, we show that successful memory encoding is also indexed by neural activity that is tonically maintained throughout a study task. Using functional magnetic reso...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn967
更新日期:2002-12-01 00:00:00
abstract::Trafficking of AMPA receptors (AMPARs) is important for many forms of synaptic plasticity. However, the link between activity and resulting synaptic alterations is not fully understood. We identified a direct interaction between N-ethylmaleimide-sensitive fusion protein (NSF), an ATPase involved in membrane fusion eve...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2624
更新日期:2010-10-01 00:00:00
abstract::The autosomal dominant disorder neurofibromatosis type 2 (NF2) is a hereditary tumor syndrome caused by inactivation of the NF2 tumor suppressor gene, encoding merlin. Apart from tumors affecting the peripheral and central nervous systems, most NF2 patients develop peripheral neuropathies. This peripheral nerve diseas...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3348
更新日期:2013-04-01 00:00:00
abstract::Memory is supported by a specific ensemble of neurons distributed in the brain that form a unique memory trace. We previously showed that neurons in the lateral amygdala expressing elevated levels of cAMP response-element binding protein are preferentially recruited into fear memory traces and are necessary for the ex...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3592
更新日期:2014-01-01 00:00:00
abstract::Interleukin 17 (IL-17) is a signature cytokine of Th17 cells. We previously reported that deletion of NF-κB activator 1 (Act1), the key transducer of IL-17 receptor signaling, from the neuroectodermal lineage in mice (neurons, oligodendrocytes and astrocytes) results in attenuated severity of experimental autoimmune e...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3505
更新日期:2013-10-01 00:00:00
abstract::Laboratory models, including animal tissues and live animals, have proven useful for discovery of molecular targets of alcohol action as well as for characterization of genetic and environmental factors that influence alcohol's neural actions. Here we consider strengths and weaknesses of laboratory models used in alco...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn1581
更新日期:2005-11-01 00:00:00
abstract::Many neural signaling receptors are regulated by endocytosis, but little is known about receptor insertion into the plasma membrane. Time-lapse imaging of the beta2 adrenergic receptor expressed in cultured rat hippocampal neurons, using pH-sensitive green fluorescent protein tagging and total internal reflection fluo...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1679
更新日期:2006-05-01 00:00:00
abstract::Voltage-gated sodium channels (Na(V)) are critical for initiation of action potentials. Heterozygous loss-of-function mutations in Na(V)1.1 channels cause severe myoclonic epilepsy in infancy (SMEI). Homozygous null Scn1a-/- mice developed ataxia and died on postnatal day (P) 15 but could be sustained to P17.5 with ma...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1754
更新日期:2006-09-01 00:00:00
abstract::The ventral intraparietal area (VIP) receives converging inputs from visual, somatosensory, auditory and vestibular systems that use diverse reference frames to encode sensory information. A key issue is how VIP combines those inputs together. We mapped the visual and tactile receptive fields of multimodal VIP neurons...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1480
更新日期:2005-07-01 00:00:00
abstract::The dorsal root ganglia (DRG) contain a variety of mechanoreceptors, but no molecular markers uniquely identify specific mechanoreceptor subtypes. We have used DNA microarrays and subtracted cDNA libraries to isolate genes that are specifically expressed by one type of mouse mechanoreceptor. The T-type calcium channel...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1076
更新日期:2003-07-01 00:00:00
abstract::Electrophysiological connectivity patterns in cortex often have a few strong connections, which are sometimes bidirectional, among a lot of weak connections. To explain these connectivity patterns, we created a model of spike timing-dependent plasticity (STDP) in which synaptic changes depend on presynaptic spike arri...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2479
更新日期:2010-03-01 00:00:00
abstract::The spinal cord is the initial stage that integrates temperature information from peripheral inputs. Here we used molecular genetics and in vivo calcium imaging to investigate the coding of cutaneous temperature in the spinal cord in mice. We found that heating or cooling the skin evoked robust calcium responses in sp...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4350
更新日期:2016-09-01 00:00:00
abstract::Radial glial progenitor cells exhibit bidirectional cell cycle-dependent nuclear oscillations. The purpose and underlying mechanism of this unusual 'interkinetic nuclear migration' are poorly understood. We investigated the basis for this behavior by live imaging of nuclei, centrosomes and microtubules in embryonic ra...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2665
更新日期:2010-12-01 00:00:00
abstract::Repeated cocaine administration increases the dendritic arborization of nucleus accumbens neurons, but the underlying signaling events remain unknown. Here we show that repeated exposure to cocaine negatively regulates the active form of Rac1, a small GTPase that controls actin remodeling in other systems. Further, we...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3094
更新日期:2012-06-01 00:00:00
abstract::In the version of this article initially published, paragraph 8 mentioned intra-accumbens administration of SB334867. This should have read systemic (intraperitoneal) administration. The error has been corrected in the HTML and PDF versions of the article. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-018-0111-7
更新日期:2018-06-01 00:00:00
abstract::Bright objects capture our attention by virtue of 'popping out' from their surroundings. This correlates with strong responses in cortical areas thought to be important in attentional allocation. Previous studies have suggested that with the right mindset or training, humans can ignore popout stimuli. We studied the a...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1734
更新日期:2006-08-01 00:00:00
abstract::Nature Neuroscience presents a special issue of recent advances on shared mechanisms underlying neurodegenerative disease. ...
journal_title:Nature neuroscience
pub_type: 社论
doi:10.1038/s41593-018-0250-x
更新日期:2018-10-01 00:00:00
abstract::Class I histone deacetylases (HDACs) Hdac1 and Hdac2 can associate together in protein complexes with transcriptional factors such as methyl-CpG-binding protein 2 (MeCP2). Given their high degree of sequence identity, we examined whether Hdac1 and Hdac2 were functionally redundant in mature mouse brain. We demonstrate...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4395
更新日期:2016-11-01 00:00:00
abstract::Understanding the origins and evolution of synapses may provide insight into species diversity and the organization of the brain. Using comparative proteomics and genomics, we examined the evolution of the postsynaptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes (MASCs...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2135
更新日期:2008-07-01 00:00:00
abstract::From insects to mammals, olfactory receptor neurons (ORNs) expressing a common olfactory receptor target their axons to specific glomeruli with high precision. Here we show in Drosophila that the POU transcription factor Acj6 controls the axon targeting specificity of a subset of ORN classes, as defined by the olfacto...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1284
更新日期:2004-08-01 00:00:00
abstract::Rapid eye movement (REM) sleep has been considered important for consolidation of memories, particularly of skills. Contrary to expectations, we found that REM sleep suppression by administration of selective serotonin or norepinephrine re-uptake inhibitors after training did not impair consolidation of skills or word...
journal_title:Nature neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/nn.2206
更新日期:2009-04-01 00:00:00
abstract::GABA interneurons play a critical role in higher brain functions. Astrocytic glial cells interact with synapses throughout the whole brain and are recognized as regulatory elements of excitatory synaptic transmission. However, it is largely unknown how GABAergic interneurons and astrocytes interact and contribute to s...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-00752-x
更新日期:2021-01-01 00:00:00
abstract::Emotions operate along the dimension of approach and aversion, and it is reasonable to assume that orienting behavior is intrinsically linked to emotionally involved processes such as preference decisions. Here we describe a gaze 'cascade effect' that was present when human observers were shown pairs of human faces an...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1150
更新日期:2003-12-01 00:00:00
abstract::Neurons in the rat primary auditory cortex (A1) generally cannot respond to tone sequences faster than 12 pulses per second (pps). To test whether experience can modify this maximum following rate in adult rats, trains of brief tones with random carrier frequency but fixed repetition rate were paired with electrical s...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/3729
更新日期:1998-12-01 00:00:00
abstract::The balance between proliferation and apoptosis is critical for proper development of the nervous system. Yet, little is known about molecules that regulate apoptosis of proliferative neurons. Here we identify a soluble, secreted form of CPG15 expressed in embryonic rat brain regions undergoing rapid proliferation and...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1407
更新日期:2005-03-01 00:00:00
abstract::Glycine receptors (GlyRs), together with GABA(A) and nicotinic acetylcholine (ACh) receptors, form part of the ligand-activated ion channel superfamily and regulate the excitability of the mammalian brain stem and spinal cord. Here we report that the ability of the neurotransmitter glycine to gate recombinant and nati...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1095
更新日期:2003-08-01 00:00:00
abstract::Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4289
更新日期:2016-06-01 00:00:00
abstract::Fear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to induce synaptic plasti...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3491
更新日期:2013-10-01 00:00:00
abstract::Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein causes neurodegeneration remain unknown. Here we show that lymphoblast mitochondria from patients with HD have a lower membrane potential and ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn884
更新日期:2002-08-01 00:00:00