A T-type calcium channel required for normal function of a mammalian mechanoreceptor.

abstract：:In Huntington's disease (HD), whether transneuronal spreading of mutant huntingtin (mHTT) occurs and its contribution to non-cell autonomous damage in brain networks is largely unknown. We found mHTT spreading in three different neural network models: human neurons integrated in the neural network of organotypic brain...

journal_title：Nature neuroscience

authors： Pecho-Vrieseling E,Rieker C,Fuchs S,Bleckmann D,Esposito MS,Botta P,Goldstein C,Bernhard M,Galimberti I,Müller M,Lüthi A,Arber S,Bouwmeester T,van der Putten H,Di Giorgio FP

更新日期：2014-08-01 00:00:00

abstract：:Two studies in this issue show that the protein MeCP2, which is implicated in Rett syndrome, also critically regulates behavioral responses to psychostimulants. Although the two studies highlight different mechanisms of MeCP2 in regulating these behaviors, both underscore the importance of epigenetic mechanisms in est...

journal_title：Nature neuroscience

authors： Feng J,Nestler EJ

更新日期：2010-09-01 00:00:00

abstract：:Learning to adapt to a complex and fluctuating environment requires the ability to adjust neural representations of sensory stimuli. Through pattern completion processes, cortical networks can reconstruct familiar patterns from degraded input patterns, whereas pattern separation processes allow discrimination of even ...

journal_title：Nature neuroscience

authors： Chapuis J,Wilson DA

更新日期：2011-11-20 00:00:00

abstract：:Cuing covert spatial attention can increase spatial resolution. Here we pinpointed the specific locus of this effect using texture segmentation. At the level of visual cortex, texture segmentation theoretically involves passage of visual input through two layers of spatial linear filters separated by a pointwise nonli...

journal_title：Nature neuroscience

authors： Yeshurun Y,Carrasco M

更新日期：2000-06-01 00:00:00

abstract：:Dendritic spikes signal synaptic integration at remote apical dendritic sites in neocortical pyramidal neurons in vitro. Do dendritic spikes have a salient signaling role under in vivo conditions, where neocortical pyramidal neurons are bombarded with synaptic input? In the present study, levels of synaptic conductanc...

journal_title：Nature neuroscience

authors： Williams SR

更新日期：2004-09-01 00:00:00

abstract：:Candidate Drosophila olfactory receptors (ORs) provide molecular tools to investigate how the organization of the Drosophila olfactory system determines the coding of olfactory stimuli. Neurons in the third antennal segment and maxillary palp appear to express different ORs. Individual olfactory neurons send axonal pr...

journal_title：Nature neuroscience

authors： Gao Q,Yuan B,Chess A

更新日期：2000-08-01 00:00:00

abstract：:Binocular competition is thought to drive eye-specific segregation in the developing visual system, potentially through Hebbian synaptic learning rules that are sensitive to correlations in afferent activity. Altering retinal activity can disrupt eye-specific segregation, but little is known about the temporal feature...

journal_title：Nature neuroscience

authors： Zhang J,Ackman JB,Xu HP,Crair MC

更新日期：2011-11-18 00:00:00

abstract：:The endocytosis of AMPA receptors is thought to be important in the expression of long-term depression (LTD) triggered by NMDA receptor activation. Although signaling pathways necessary for LTD induction have been identified, those responsible for the regulated internalization of AMPA receptors are unknown. Here we sh...

journal_title：Nature neuroscience

authors： Beattie EC,Carroll RC,Yu X,Morishita W,Yasuda H,von Zastrow M,Malenka RC

更新日期：2000-12-01 00:00:00

abstract：:Microcircuits composed of principal neuron and interneuron dendrites have an important role in shaping the representation of sensory information in the olfactory bulb. Here we establish the physiological features governing synaptic signaling in dendrodendritic microcircuits of olfactory bulb glomeruli. We show that de...

journal_title：Nature neuroscience

authors： Murphy GJ,Darcy DP,Isaacson JS

更新日期：2005-03-01 00:00:00

abstract：:Exposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-associated release of noradrenaline enhances the capacity of central synapses to show plasticity (metaplasticity). We found noradrenaline-dependent metaplasticity at GABA synapses in the paraventricular nucleus of the hypot...

journal_title：Nature neuroscience

authors： Inoue W,Baimoukhametova DV,Füzesi T,Wamsteeker Cusulin JI,Koblinger K,Whelan PJ,Pittman QJ,Bains JS

更新日期：2013-05-01 00:00:00

abstract：:Phagocytic cell NADPH oxidase (NOX) generates reactive oxygen species (ROS) as part of innate immunity. Unfortunately, ischemia can also induce this pathway and inflict damage on native cells. The voltage-gated proton channel Hv1 enables NOX function by compensating cellular loss of electrons with protons. Accordingly...

journal_title：Nature neuroscience

authors： Wu LJ,Wu G,Akhavan Sharif MR,Baker A,Jia Y,Fahey FH,Luo HR,Feener EP,Clapham DE

更新日期：2012-03-04 00:00:00

abstract：:Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar. Restricted access to such memories can present a risk for psychiatric disorders and hamper their treatment. To better understand the mechanisms underlying state-dependent fe...

journal_title：Nature neuroscience

authors： Jovasevic V,Corcoran KA,Leaderbrand K,Yamawaki N,Guedea AL,Chen HJ,Shepherd GM,Radulovic J

更新日期：2015-09-01 00:00:00

abstract：:We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wild-type mice. DSBs occurred in multiple brain regions, were most abundant in the dentate gyrus, which is involved in learning and memory, and were repaired within 24 h. Increasing neu...

journal_title：Nature neuroscience

authors： Suberbielle E,Sanchez PE,Kravitz AV,Wang X,Ho K,Eilertson K,Devidze N,Kreitzer AC,Mucke L

更新日期：2013-05-01 00:00:00

abstract：:It is widely believed that attention selects locations at an earlier stage than it selects nonspatial features, but this has been tested only under conditions of minimal competition. We found that, when competition was increased, color-based attention was able to influence the feedforward flow of information in humans...

journal_title：Nature neuroscience

authors： Zhang W,Luck SJ

更新日期：2009-01-01 00:00:00

abstract：:Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 receptors are mostly expressed in postsynaptic neurons, pharmacological and genetic approaches have been unable to definitively address the in viv...

journal_title：Nature neuroscience

authors： Bello EP,Mateo Y,Gelman DM,Noaín D,Shin JH,Low MJ,Alvarez VA,Lovinger DM,Rubinstein M

更新日期：2011-07-10 00:00:00

abstract：:We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital...

journal_title：Nature neuroscience

authors： Armentano M,Chou SJ,Tomassy GS,Leingärtner A,O'Leary DD,Studer M

更新日期：2007-10-01 00:00:00

abstract：:Short-term synaptic plasticity is a defining feature of neuronal activity, but the underlying molecular mechanisms are poorly understood. Depression of synaptic activity might be due to limited vesicle availability, whereas facilitation is thought to result from elevated calcium levels. However, it is unclear whether ...

journal_title：Nature neuroscience

authors： Sippy T,Cruz-Martín A,Jeromin A,Schweizer FE

更新日期：2003-10-01 00:00:00

abstract：:Much of the information processing in the brain occurs at the level of local circuits; however, the mechanisms underlying their initial development are poorly understood. We sought to examine the early development and plasticity of local excitatory circuits in the optic tectum of Xenopus laevis tadpoles. We found that...

journal_title：Nature neuroscience

authors： Pratt KG,Dong W,Aizenman CD

更新日期：2008-04-01 00:00:00

abstract：:The efficiency of remyelination decreases with age, but the molecular mechanisms responsible for this decline remain only partially understood. In this study, we show that remyelination is regulated by age-dependent epigenetic control of gene expression. In demyelinated young brains, new myelin synthesis is preceded b...

journal_title：Nature neuroscience

authors： Shen S,Sandoval J,Swiss VA,Li J,Dupree J,Franklin RJ,Casaccia-Bonnefil P

更新日期：2008-09-01 00:00:00

abstract：:An unresolved question in neuroscience relates to the extent to which corticothalamocortical circuits emanating from layer 5B are involved in information transfer through the cortical hierarchy. Using a new form of optical imaging in a brain slice preparation, we found that the corticothalamocortical pathway drove rob...

journal_title：Nature neuroscience

authors： Theyel BB,Llano DA,Sherman SM

更新日期：2010-01-01 00:00:00

abstract：:The projections and odor responses of mammalian olfactory receptor neurons, as well as the physiology of the bulb's principal neurons-the mitral cells (MCs)-are known from studies in slices and anesthetized animals. In behaving rats trained to discriminate between two odors associated with different reinforcers, we ex...

journal_title：Nature neuroscience

authors： Kay LM,Laurent G

更新日期：1999-11-01 00:00:00

abstract：:Multiple protein kinase C (PKC) isozymes are present in neurons, where they regulate a variety of cellular functions. Due to the lack of specific PKC isozyme inhibitors, it remains unknown how PKC acts on its selective target(s) and achieves its specific actions. Here we show that a PKC binding protein, enigma homolog...

journal_title：Nature neuroscience

authors： Maeno-Hikichi Y,Chang S,Matsumura K,Lai M,Lin H,Nakagawa N,Kuroda S,Zhang JF

更新日期：2003-05-01 00:00:00

abstract：:Economic choice entails assigning values to the available options and is impaired by lesions to the orbitofrontal cortex (OFC). Recent results show that some neurons in the OFC encode the values that monkeys (Macaca mulatta) assign to different goods when they choose between them. A broad and fundamental question is h...

journal_title：Nature neuroscience

authors： Padoa-Schioppa C,Assad JA

更新日期：2008-01-01 00:00:00

abstract：:Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein causes neurodegeneration remain unknown. Here we show that lymphoblast mitochondria from patients with HD have a lower membrane potential and ...

journal_title：Nature neuroscience

authors： Panov AV,Gutekunst CA,Leavitt BR,Hayden MR,Burke JR,Strittmatter WJ,Greenamyre JT

更新日期：2002-08-01 00:00:00

abstract：:Tau protein can transfer between neurons transneuronally and trans-synaptically, which is thought to explain the progressive spread of tauopathy observed in the brain of patients with Alzheimer's disease. Here we show that physiological tau released from donor cells can transfer to recipient cells via the medium, sugg...

journal_title：Nature neuroscience

authors： Wu JW,Hussaini SA,Bastille IM,Rodriguez GA,Mrejeru A,Rilett K,Sanders DW,Cook C,Fu H,Boonen RA,Herman M,Nahmani E,Emrani S,Figueroa YH,Diamond MI,Clelland CL,Wray S,Duff KE

更新日期：2016-08-01 00:00:00

abstract：:Axon guidance cues contributing to the development of eye-specific visual projections to the lateral geniculate nucleus (LGN) have not previously been identified. Here we show that gradients of ephrin-As and their receptors (EphAs) direct retinal ganglion cell (RGC) axons from the two eyes into their stereotyped patte...

journal_title：Nature neuroscience

authors： Huberman AD,Murray KD,Warland DK,Feldheim DA,Chapman B

更新日期：2005-08-01 00:00:00

abstract：:Ca(v)2.1 channels, which mediate P/Q-type Ca2+ currents, undergo Ca2+/calmodulin (CaM)-dependent inactivation and facilitation that can significantly alter synaptic efficacy. Here we report that the neuronal Ca2+-binding protein 1 (CaBP1) modulates Ca(v)2.1 channels in a manner that is markedly different from modulati...

journal_title：Nature neuroscience

authors： Lee A,Westenbroek RE,Haeseleer F,Palczewski K,Scheuer T,Catterall WA

更新日期：2002-03-01 00:00:00

abstract：:Cognition can be conceptualized as a set of algorithmic control functions whose real-time deployment determines how an organism stores and uses information to guide thought and action. A subset of these functions is required for goal-directed selection and amplification of sensory signals-broadly referred to as attent...

journal_title：Nature neuroscience

authors： Halassa MM,Kastner S

更新日期：2017-12-01 00:00:00

abstract：:We report on two brain-damaged subjects who exhibit the uncommon pattern of loss of object color knowledge, but spared color perception and naming. The subject P.C.O., as in previously reported patients, is also impaired in processing other perceptual and functional properties of objects. I.O.C., in contrast, is the f...

journal_title：Nature neuroscience

authors： Miceli G,Fouch E,Capasso R,Shelton JR,Tomaiuolo F,Caramazza A

更新日期：2001-06-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is genetically heterogeneous with convergent symptomatology, suggesting common dysregulated pathways. In this study, we analyzed brain transcriptional changes in five mouse models of Pitt-Hopkins syndrome (PTHS), a syndromic form of ASD caused by mutations in the TCF4 gene, but not the T...

journal_title：Nature neuroscience

authors： Phan BN,Bohlen JF,Davis BA,Ye Z,Chen HY,Mayfield B,Sripathy SR,Cerceo Page S,Campbell MN,Smith HL,Gallop D,Kim H,Thaxton CL,Simon JM,Burke EE,Shin JH,Kennedy AJ,Sweatt JD,Philpot BD,Jaffe AE,Maher BJ

更新日期：2020-03-01 00:00:00