Abstract:
:Axon guidance cues contributing to the development of eye-specific visual projections to the lateral geniculate nucleus (LGN) have not previously been identified. Here we show that gradients of ephrin-As and their receptors (EphAs) direct retinal ganglion cell (RGC) axons from the two eyes into their stereotyped pattern of layers in the LGN. Overexpression of EphAs in ferret RGCs using in vivo electroporation induced axons from both eyes to misproject within the LGN. The effects of EphA overexpression were competition-dependent and restricted to the early postnatal period. These findings represent the first demonstration of eye-specific pathfinding mediated by axon guidance cues and, taken with other reports, indicate that ephrin-As can mediate several mapping functions within individual target structures.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Huberman AD,Murray KD,Warland DK,Feldheim DA,Chapman Bdoi
10.1038/nn1505subject
Has Abstractpub_date
2005-08-01 00:00:00pages
1013-21issue
8eissn
1097-6256issn
1546-1726pii
nn1505journal_volume
8pub_type
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