Abstract:
:Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) of Flag-tagged-H1.0 in mouse forebrain excitatory neurons. Unexpectedly, Flag-H1.0 and MeCP2 occupied similar genomic regions and the Flag-H1.0 binding was not changed upon MeCP2 depletion. Furthermore, mild overexpression of H1.0 did not alter MeCP2 binding, suggesting that the functional binding of MeCP2 and H1.0 are largely independent.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Ito-Ishida A,Yamalanchili HK,Shao Y,Baker SA,Heckman LD,Lavery LA,Kim JY,Lombardi LM,Sun Y,Liu Z,Zoghbi HYdoi
10.1038/s41593-018-0155-8subject
Has Abstractpub_date
2018-06-01 00:00:00pages
794-798issue
6eissn
1097-6256issn
1546-1726pii
10.1038/s41593-018-0155-8journal_volume
21pub_type
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