Abstract:
:The US government is re-examining how it funds science, but it remains to be seen whether the administration can overcome tradition and bureaucratic inertia and achieve a substantial renovation of the grants peer-review system.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
doi
10.1038/nn0208-119subject
Has Abstractpub_date
2008-02-01 00:00:00pages
119issue
2eissn
1097-6256issn
1546-1726pii
nn0208-119journal_volume
11pub_type
社论abstract::Although inherently linked, body form and body action may be represented in separate neural substrates. Using repetitive transcranial magnetic stimulation in healthy individuals, we show that interference with the extrastriate body area impairs the discrimination of bodily forms, and interference with the ventral prem...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1815
更新日期:2007-01-01 00:00:00
abstract::Transposable elements, known colloquially as 'jumping genes', constitute approximately 45% of the human genome. Cells utilize epigenetic defenses to limit transposable element jumping, including formation of silencing heterochromatin and generation of piwi-interacting RNAs (piRNAs), small RNAs that facilitate clearanc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0194-1
更新日期:2018-08-01 00:00:00
abstract::Neurons in the rat primary auditory cortex (A1) generally cannot respond to tone sequences faster than 12 pulses per second (pps). To test whether experience can modify this maximum following rate in adult rats, trains of brief tones with random carrier frequency but fixed repetition rate were paired with electrical s...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/3729
更新日期:1998-12-01 00:00:00
abstract::The endocytosis of AMPA receptors is thought to be important in the expression of long-term depression (LTD) triggered by NMDA receptor activation. Although signaling pathways necessary for LTD induction have been identified, those responsible for the regulated internalization of AMPA receptors are unknown. Here we sh...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/81823
更新日期:2000-12-01 00:00:00
abstract::The development of neuronal networks in the neocortex depends on control mechanisms for mitosis and migration that allow newborn neurons to find their accurate position. Multiple mitogens, neurotrophic factors, guidance molecules and their corresponding receptors are involved in this process, but the mechanisms by whi...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3333
更新日期:2013-04-01 00:00:00
abstract::The distinct electrical properties of axonal and dendritic membranes are largely a result of specific transport of vesicle-bound membrane proteins to each compartment. How this specificity arises is unclear because kinesin motors that transport vesicles cannot autonomously distinguish dendritically projecting microtub...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2318
更新日期:2009-05-01 00:00:00
abstract::Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1301
更新日期:2004-09-01 00:00:00
abstract::In the version of this article initially published online, the accession code was given as GSE1000333. The correct code is GSE100033. The error has been corrected in the print, HTML and PDF versions of the article. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-018-0114-4
更新日期:2018-07-01 00:00:00
abstract::In the cat primary visual cortex, neurons are classified into the two main categories of simple cells and complex cells based on their response properties. According to the hierarchical model, complex receptive fields derive from convergent inputs of simple cells with similar orientation preferences. This model receiv...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/1609
更新日期:1998-09-01 00:00:00
abstract::The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure and function. We applied a correlation-based metric called differential stability to assess reproducibility of gene expression patterning across 132 structure...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4171
更新日期:2015-12-01 00:00:00
abstract::Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants, but the mechanisms by which they influence behavior are only partially resolved. Adult hippocampal neurogenesis is necessary for some of the responses to SSRIs, but it is not known whether mature dentate gyrus granule cells (DG GCs) also ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4116
更新日期:2015-11-01 00:00:00
abstract::In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation w...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1650
更新日期:2006-03-01 00:00:00
abstract::The C. elegans SAX-3/Robo receptor acts in anterior-posterior, dorsal-ventral and midline guidance decisions. Here we show that SAX-3 signaling involves the C. elegans Enabled protein UNC-34 and an unexpected Netrin-independent function of the Netrin receptor UNC-40/DCC. Genetic interactions with gain- and loss-of-fun...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn956
更新日期:2002-11-01 00:00:00
abstract::Using magnetoencephalography (MEG), we compared the processing of sinusoidal tones in the auditory cortex of 12 non-musicians, 12 professional musicians and 13 amateur musicians. We found neurophysiological and anatomical differences between groups. In professional musicians as compared to non-musicians, the activity ...
journal_title:Nature neuroscience
pub_type: 临床试验,杂志文章
doi:10.1038/nn871
更新日期:2002-07-01 00:00:00
abstract::Head-direction cells have frequently been regarded as an internal 'compass' that can be used for navigation, although there is little evidence showing a link between their activity and spatial behavior. In a navigational task requiring the use of internal cues to return to a home location without vision (path integrat...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3215
更新日期:2012-10-01 00:00:00
abstract::Many attempts to obtain reliable self-administration behavior by laboratory animals with delta-9-tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, have been unsuccessful. Because self-administration behavior has been demonstrated in laboratory animals for almost all other psychoactive drugs abused ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/80577
更新日期:2000-11-01 00:00:00
abstract::Speech and vocal impairments characterize many neurological disorders. However, the neurogenetic mechanisms of these disorders are not well understood, and current animal models do not have the necessary circuitry to recapitulate vocal learning deficits. We developed germline transgenic songbirds, zebra finches (Tanei...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4133
更新日期:2015-11-01 00:00:00
abstract::Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 receptors are mostly expressed in postsynaptic neurons, pharmacological and genetic approaches have been unable to definitively address the in viv...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2862
更新日期:2011-07-10 00:00:00
abstract::Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3625
更新日期:2014-02-01 00:00:00
abstract::Many types of neurons can release endocannabinoids that act as retrograde signals to inhibit neurotransmitter release from presynaptic terminals. Little is known, however, about the properties or role of such inhibition under physiological conditions. Here we report that brief bursts of presynaptic activity evoked end...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1126
更新日期:2003-10-01 00:00:00
abstract::Economic choice entails assigning values to the available options and is impaired by lesions to the orbitofrontal cortex (OFC). Recent results show that some neurons in the OFC encode the values that monkeys (Macaca mulatta) assign to different goods when they choose between them. A broad and fundamental question is h...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2020
更新日期:2008-01-01 00:00:00
abstract::The neural basis of aggression is poorly understood. A study in this issue used genetic scalpels to dissect the circuitry of the fly brain and identified a small cluster of octopaminergic neurons that can make a fly fighting mad. ...
journal_title:Nature neuroscience
pub_type: 评论,杂志文章,评审
doi:10.1038/nn0908-989
更新日期:2008-09-01 00:00:00
abstract::To determine the number of open Ca(2+) channels necessary for transmitter release at the inhibitory basket cell-granule cell synapse in rat hippocampus, we combined presynaptic Ca(2+) imaging, recording of postsynaptic currents and modeling. We found that that the opening of three or fewer Ca(2+) channels triggered tr...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2461
更新日期:2010-01-01 00:00:00
abstract::The control of cell fate in neural progenitor cells is critical for nervous system development. Nevertheless, the processes involved are only partially known. We found that the expression of the tumor suppressor Pml was restricted to neural progenitor cells (NPCs) in the developing neocortex of the mouse. Notably, in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2251
更新日期:2009-02-01 00:00:00
abstract::We used high-level configural aftereffects induced by adaptation to realistic faces to investigate visual representations underlying complex pattern perception. We found that exposure to an individual face for a few seconds generated a significant and precise bias in the subsequent perception of face identity. In the ...
journal_title:Nature neuroscience
pub_type: 临床试验,杂志文章
doi:10.1038/82947
更新日期:2001-01-01 00:00:00
abstract::The endocytosis of AMPA receptors (AMPARs) underlies several forms of synaptic plasticity, including NMDA receptor (NMDAR)-dependent long-term depression (LTD), but the molecular mechanisms responsible for this trafficking remain unknown. We found that PSD-95, a major postsynaptic density protein, is important for NMD...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2249
更新日期:2009-02-01 00:00:00
abstract::We combined psychophysical and transcranial magnetic stimulation studies to investigate the dynamics of action anticipation and its underlying neural correlates in professional basketball players. Athletes predicted the success of free shots at a basket earlier and more accurately than did individuals with comparable ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2182
更新日期:2008-09-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-020-00723-2
更新日期:2020-11-01 00:00:00
abstract::We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, wher...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1921
更新日期:2007-07-01 00:00:00
abstract::Bright objects capture our attention by virtue of 'popping out' from their surroundings. This correlates with strong responses in cortical areas thought to be important in attentional allocation. Previous studies have suggested that with the right mindset or training, humans can ignore popout stimuli. We studied the a...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1734
更新日期:2006-08-01 00:00:00