5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response.

abstract：:Mammalian hearing owes its remarkable sensitivity and frequency selectivity to a local mechanical feedback process within the cochlea. Cochlear outer hair cells (OHCs) function as the key elements in the feedback loop in which the fast somatic motility of OHCs is thought to be the source of cochlear amplification. An ...

journal_title：Nature neuroscience

authors： Jia S,He DZ

更新日期：2005-08-01 00:00:00

abstract：:The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A...

journal_title：Nature neuroscience

authors： He W,Lam TK,Obici S,Rossetti L

更新日期：2006-02-01 00:00:00

abstract：:The specification of area identities in the cerebral cortex is a complex process, primed by intrinsic cortical cues and refined after the arrival of afferent fibers from the thalamus. Little is known about the genetic control of the early steps of this process, but the distinctive expression pattern of the homeogene E...

journal_title：Nature neuroscience

authors： Mallamaci A,Muzio L,Chan CH,Parnavelas J,Boncinelli E

更新日期：2000-07-01 00:00:00

abstract：:Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT. Our models suggest ...

journal_title：Nature neuroscience

authors： Beuming T,Kniazeff J,Bergmann ML,Shi L,Gracia L,Raniszewska K,Newman AH,Javitch JA,Weinstein H,Gether U,Loland CJ

更新日期：2008-07-01 00:00:00

abstract：:Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger. Agouti-related protein (AgRP) neurons in the ARC (ARCAgRP neurons) are stimulated by fasting and, once activated, they rapidly (within minutes) drive hunger. Pro-opiomelanocortin (ARCPOMC) neurons are viewed as the counterpoint to ARCAgRP...

journal_title：Nature neuroscience

authors： Fenselau H,Campbell JN,Verstegen AM,Madara JC,Xu J,Shah BP,Resch JM,Yang Z,Mandelblat-Cerf Y,Livneh Y,Lowell BB

更新日期：2017-01-01 00:00:00

abstract：:Nucleus HVc of the avian song system is a forebrain structure critical in song production, perception and learning. Here we show that most HVc neurons that respond to auditory stimuli under anesthesia show no responses to the same stimulus in the awake, unrestrained bird. This suppression of auditory responses in awak...

journal_title：Nature neuroscience

authors： Schmidt MF,Konishi M

更新日期：1998-10-01 00:00:00

abstract：:Polyamines are endogenous molecules involved in cell damage following neurological insults, although it is unclear whether polyamines reduce or exacerbate this damage. We used a developmental seizure model in which we exposed Xenopus laevis tadpoles to pentylenetetrazole (PTZ), a known convulsant. We found that, after...

journal_title：Nature neuroscience

authors： Bell MR,Belarde JA,Johnson HF,Aizenman CD

更新日期：2011-04-01 00:00:00

abstract：:Shared neural variability is ubiquitous in cortical populations. While this variability is presumed to arise from overlapping synaptic input, its precise relationship to local circuit architecture remains unclear. We combine computational models and in vivo recordings to study the relationship between the spatial stru...

journal_title：Nature neuroscience

authors： Rosenbaum R,Smith MA,Kohn A,Rubin JE,Doiron B

更新日期：2017-01-01 00:00:00

abstract：:Transcriptomic analyses of postmortem brains have begun to elucidate molecular abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in synaptic development, RNA editing, has not yet been studied on a genome-wide scale. Here we profiled global patterns of adenosine-to-inosine (A-to-I) ed...

journal_title：Nature neuroscience

authors： Tran SS,Jun HI,Bahn JH,Azghadi A,Ramaswami G,Van Nostrand EL,Nguyen TB,Hsiao YE,Lee C,Pratt GA,Martínez-Cerdeño V,Hagerman RJ,Yeo GW,Geschwind DH,Xiao X

更新日期：2019-01-01 00:00:00

abstract：:The distinct electrical properties of axonal and dendritic membranes are largely a result of specific transport of vesicle-bound membrane proteins to each compartment. How this specificity arises is unclear because kinesin motors that transport vesicles cannot autonomously distinguish dendritically projecting microtub...

journal_title：Nature neuroscience

authors： Lewis TL Jr,Mao T,Svoboda K,Arnold DB

更新日期：2009-05-01 00:00:00

abstract：:The olfactory system faces a hard problem: on the basis of noisy information from olfactory receptor neurons (the neurons that transduce chemicals to neural activity), it must figure out which odors are present in the world. Odors almost never occur in isolation, and different odors excite overlapping populations of o...

journal_title：Nature neuroscience

authors： Grabska-Barwińska A,Barthelmé S,Beck J,Mainen ZF,Pouget A,Latham PE

更新日期：2017-01-01 00:00:00

abstract：:Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to ...

journal_title：Nature neuroscience

authors： Kress GJ,Yamawaki N,Wokosin DL,Wickersham IR,Shepherd GM,Surmeier DJ

更新日期：2013-06-01 00:00:00

abstract：:The cortical nucleus LMAN (lateral magnocellular nucleus of the anterior nidopallium) provides the output of a basal ganglia pathway that is necessary for vocal learning in juvenile songbirds. The shell subregion of LMAN (LMAN(shell)) gives rise to recurrent loops that may subserve specific learning-related functions....

journal_title：Nature neuroscience

authors： Bottjer SW,Altenau B

更新日期：2010-02-01 00:00:00

abstract：:Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and h...

journal_title：Nature neuroscience

authors： Mato S,Chevaleyre V,Robbe D,Pazos A,Castillo PE,Manzoni OJ

更新日期：2004-06-01 00:00:00

abstract：:Radial glial progenitor cells exhibit bidirectional cell cycle-dependent nuclear oscillations. The purpose and underlying mechanism of this unusual 'interkinetic nuclear migration' are poorly understood. We investigated the basis for this behavior by live imaging of nuclei, centrosomes and microtubules in embryonic ra...

journal_title：Nature neuroscience

authors： Tsai JW,Lian WN,Kemal S,Kriegstein AR,Vallee RB

更新日期：2010-12-01 00:00:00

abstract：:Most neurons receive thousands of synaptic inputs onto widely spread dendrites. Because of dendritic filtering, distant synapses should have less efficacy than proximal ones. To investigate this, we characterized the amplitude and kinetics of excitatory synaptic input across the apical dendrites of CA1 pyramidal neuro...

journal_title：Nature neuroscience

authors： Magee JC,Cook EP

更新日期：2000-09-01 00:00:00

abstract：:Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this view. Using several assays (FM dye imaging, pHluorin imaging and antibody-labeling of synaptotagmin)...

journal_title：Nature neuroscience

authors： Wilhelm BG,Groemer TW,Rizzoli SO

更新日期：2010-12-01 00:00:00

abstract：:Amyloid plaques are a hallmark of Alzheimer disease, but their importance in its pathogenesis is controversial. By neuronal labeling and transcranial two-photon imaging, we show in a transgenic mouse model of Alzheimer disease that dendrites passing through or near fibrillar amyloid deposits undergo spine loss and sha...

journal_title：Nature neuroscience

authors： Tsai J,Grutzendler J,Duff K,Gan WB

更新日期：2004-11-01 00:00:00

abstract：:Two studies in this issue show that the protein MeCP2, which is implicated in Rett syndrome, also critically regulates behavioral responses to psychostimulants. Although the two studies highlight different mechanisms of MeCP2 in regulating these behaviors, both underscore the importance of epigenetic mechanisms in est...

journal_title：Nature neuroscience

authors： Feng J,Nestler EJ

更新日期：2010-09-01 00:00:00

abstract：:The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places inc...

journal_title：Nature neuroscience

authors： O'Neill J,Senior TJ,Allen K,Huxter JR,Csicsvari J

更新日期：2008-02-01 00:00:00

abstract：:In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeonin...

journal_title：Nature neuroscience

authors： Nainar S,Marshall PR,Tyler CR,Spitale RC,Bredy TW

更新日期：2016-09-27 00:00:00

abstract：:Synaptic cadherin adhesion complexes are known to be key regulators of synapse plasticity. However, the molecular mechanisms that coordinate activity-induced modifications in cadherin localization and adhesion and the subsequent changes in synapse morphology and efficacy remain unknown. We demonstrate that the intrace...

journal_title：Nature neuroscience

authors： Brigidi GS,Sun Y,Beccano-Kelly D,Pitman K,Mobasser M,Borgland SL,Milnerwood AJ,Bamji SX

更新日期：2014-04-01 00:00:00

abstract：:Neurons in thalamorecipient layers of sensory cortices integrate thalamocortical and intracortical inputs. Although we know that their functional properties can arise from the convergence of thalamic inputs, intracortical circuits could also be involved in thalamocortical transformations of sensory information. We sil...

journal_title：Nature neuroscience

authors： Li YT,Ibrahim LA,Liu BH,Zhang LI,Tao HW

更新日期：2013-09-01 00:00:00

abstract：:In the published version of this article, a data point is missing from Fig. 4f, and the y-axis label reads "RFpre"; it should read "RFpref." The original article has not been corrected. The original and corrected figures are shown in the accompanying Publisher Correction. ...

journal_title：Nature neuroscience

authors： Lien AD,Scanziani M

更新日期：2018-09-01 00:00:00

abstract：:Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It is, however, unknown whether sweetness and nutritional signals engage segregated brain networks to motivate ingestion. We found in mice that separate basal ganglia circuitries mediated the hedonic and nutritional actions of ...

journal_title：Nature neuroscience

authors： Tellez LA,Han W,Zhang X,Ferreira TL,Perez IO,Shammah-Lagnado SJ,van den Pol AN,de Araujo IE

更新日期：2016-03-01 00:00:00

abstract：:Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, ...

journal_title：Nature neuroscience

authors： Miller KL,Alfaro-Almagro F,Bangerter NK,Thomas DL,Yacoub E,Xu J,Bartsch AJ,Jbabdi S,Sotiropoulos SN,Andersson JL,Griffanti L,Douaud G,Okell TW,Weale P,Dragonu I,Garratt S,Hudson S,Collins R,Jenkinson M,Matthews PM,

更新日期：2016-11-01 00:00:00

abstract：:Lateral and medial parts of entorhinal cortex (EC) convey nonspatial 'what' and spatial 'where' information, respectively, into hippocampal CA1, via both the indirect EC layer 2→ hippocampal dentate gyrus→CA3→CA1 and the direct EC layer 3→CA1 paths. However, it remains elusive how the direct path transfers distinct in...

journal_title：Nature neuroscience

authors： Li Y,Xu J,Liu Y,Zhu J,Liu N,Zeng W,Huang N,Rasch MJ,Jiang H,Gu X,Li X,Luo M,Li C,Teng J,Chen J,Zeng S,Lin L,Zhang X

更新日期：2017-04-01 00:00:00

abstract：:Recording from neural networks at the resolution of action potentials is critical for understanding how information is processed in the brain. Here, we address this challenge by developing an organic material-based, ultraconformable, biocompatible and scalable neural interface array (the 'NeuroGrid') that can record b...

journal_title：Nature neuroscience

authors： Khodagholy D,Gelinas JN,Thesen T,Doyle W,Devinsky O,Malliaras GG,Buzsáki G

更新日期：2015-02-01 00:00:00

abstract：:Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment...

journal_title：Nature neuroscience

authors： Girardeau G,Benchenane K,Wiener SI,Buzsáki G,Zugaro MB

更新日期：2009-10-01 00:00:00

abstract：:Retinal bipolar cells have been assumed to generate purely graded responses to light. To test this idea we imaged the presynaptic calcium transient in live zebrafish. We found that ON, OFF, transient and sustained bipolar cells are all capable of generating fast 'all-or-none' calcium transients modulated by visual sti...

journal_title：Nature neuroscience

authors： Dreosti E,Esposti F,Baden T,Lagnado L

更新日期：2011-06-26 00:00:00