Abstract：
:Recording from neural networks at the resolution of action potentials is critical for understanding how information is processed in the brain. Here, we address this challenge by developing an organic material-based, ultraconformable, biocompatible and scalable neural interface array (the 'NeuroGrid') that can record both local field potentials(LFPs) and action potentials from superficial cortical neurons without penetrating the brain surface. Spikes with features of interneurons and pyramidal cells were simultaneously acquired by multiple neighboring electrodes of the NeuroGrid, allowing for the isolation of putative single neurons in rats. Spiking activity demonstrated consistent phase modulation by ongoing brain oscillations and was stable in recordings exceeding 1 week's duration. We also recorded LFP-modulated spiking activity intraoperatively in patients undergoing epilepsy surgery. The NeuroGrid constitutes an effective method for large-scale, stable recording of neuronal spikes in concert with local population synaptic activity, enhancing comprehension of neural processes across spatiotemporal scales and potentially facilitating diagnosis and therapy for brain disorders.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Khodagholy D,Gelinas JN,Thesen T,Doyle W,Devinsky O,Malliaras GG,Buzsáki Gdoi
10.1038/nn.3905subject
Has Abstractpub_date
2015-02-01 00:00:00pages
310-5issue
2eissn
1097-6256issn
1546-1726pii
nn.3905journal_volume
18pub_type
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