Abstract：
:The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A) were injected bilaterally into the mediobasal hypothalamus of rats. MCD overexpression led to decreased abundance of long-chain fatty acyl-coenzyme A in the mediobasal hypothalamus and blunted the hypothalamic responses to increased lipid availability. The enhanced expression of MCD within this hypothalamic region induced a rapid increase in food intake and progressive weight gain. Obesity was sustained for at least 4 months and occurred despite increased plasma concentrations of leptin and insulin. These findings indicate that nutritional modulation of the hypothalamic abundance of malonyl-coenzyme A is required to restrain food intake and that a primary impairment in this central nutrient-sensing pathway is sufficient to disrupt energy homeostasis and induce obesity.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
He W,Lam TK,Obici S,Rossetti Ldoi
10.1038/nn1626subject
Has Abstractpub_date
2006-02-01 00:00:00pages
227-33issue
2eissn
1097-6256issn
1546-1726pii
nn1626journal_volume
9pub_type
杂志文章abstract：:Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 receptors are mostly expressed in postsynaptic neurons, pharmacological and genetic approaches have been unable to definitively address the in viv...
journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2011-07-10 00:00:00
abstract：:In the version of this article initially published, what was originally described as 'conditioned place preference' in a two-chamber mouse experiment could be better described as 'conditioned place avoidance'. ...
journal_title：Nature neuroscience
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journal_title：Nature neuroscience
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journal_title：Nature neuroscience
pub_type： 杂志文章,评审
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journal_title：Nature neuroscience
pub_type： 杂志文章
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/8123
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journal_title：Nature neuroscience
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journal_title：Nature neuroscience
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journal_title：Nature neuroscience
pub_type： 已发布勘误
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journal_title：Nature neuroscience
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2011-04-01 00:00:00
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journal_title：Nature neuroscience
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更新日期：2017-05-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2011-05-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 评论,杂志文章,评审
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更新日期：2009-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章,评审
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更新日期：2009-06-01 00:00:00
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journal_title：Nature neuroscience
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2013-11-01 00:00:00
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journal_title：Nature neuroscience
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