Abstract:
:In the published version of this article, a data point is missing from Fig. 4f, and the y-axis label reads "RFpre"; it should read "RFpref." The original article has not been corrected. The original and corrected figures are shown in the accompanying Publisher Correction.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Lien AD,Scanziani Mdoi
10.1038/s41593-018-0181-6subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1292issue
9eissn
1097-6256issn
1546-1726pii
10.1038/s41593-018-0181-6journal_volume
21pub_type
已发布勘误abstract::The cortical nucleus LMAN (lateral magnocellular nucleus of the anterior nidopallium) provides the output of a basal ganglia pathway that is necessary for vocal learning in juvenile songbirds. The shell subregion of LMAN (LMAN(shell)) gives rise to recurrent loops that may subserve specific learning-related functions....
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2472
更新日期:2010-02-01 00:00:00
abstract::Neural activity exhibits complex dynamics related to various brain functions, internal states and behaviors. Understanding how neural dynamics explain specific measured behaviors requires dissociating behaviorally relevant and irrelevant dynamics, which is not achieved with current neural dynamic models as they are le...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-00733-0
更新日期:2021-01-01 00:00:00
abstract::Human behavior is mostly composed of habitual actions that require little conscious control. Such actions may become invalid if the environment changes, at which point individuals need to switch behavior by overcoming habitual actions that are otherwise triggered automatically. It is unknown how the brain controls thi...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1830
更新日期:2007-02-01 00:00:00
abstract::As the neural network becomes wired, postsynaptic signaling molecules are thought to control the growth of dendrites and synapses. However, how these molecules are coordinated to sculpt postsynaptic structures is less well understood. We find that ephrin-B3, a transmembrane ligand for Eph receptors, functions postsyna...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2931
更新日期:2011-10-02 00:00:00
abstract::Nucleus accumbens (NAc) dopamine is widely implicated in mediating the reinforcing effects of drugs of abuse. However, the precise function of the NAc itself in drug self-administration has been difficult to establish. Here we show a neural double-dissociation of the behavioral processes that underlie cocaine self-adm...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1217
更新日期:2004-04-01 00:00:00
abstract::The spinal cord is the initial stage that integrates temperature information from peripheral inputs. Here we used molecular genetics and in vivo calcium imaging to investigate the coding of cutaneous temperature in the spinal cord in mice. We found that heating or cooling the skin evoked robust calcium responses in sp...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4350
更新日期:2016-09-01 00:00:00
abstract::Processing of rapidly successive acoustic stimuli can be markedly improved by sensory training. To investigate the cortical mechanisms underlying such temporal plasticity, we trained rats in a 'sound maze' in which navigation using only auditory cues led to a target location paired with food reward. In this task, the ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1293
更新日期:2004-09-01 00:00:00
abstract::Understanding the transcriptional changes that are engaged in stress resilience may reveal novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing data from brains of resilient mice to identify a gene network that is unique to resilience. Zfp189, which encodes a previously unstudied zin...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0462-8
更新日期:2019-09-01 00:00:00
abstract::Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in the neurovascular unit between endothelial cells, astrocytes and neurons. This position allows them to regulate key neurovascular functions of the brain. The role of pericytes in the regulation of cerebral blood flow (CBF) an...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4489
更新日期:2017-03-01 00:00:00
abstract::Mammalian sterile 20-like kinase-3b (Mst3b, encoded by Stk24), regulates axon outgrowth in embryonic cortical neurons in culture, but its role in vivo and in neural repair is unknown. Here we show that Mst3b mediates the axon-promoting effects of trophic factors in mature rat retinal ganglion cells (RGCs) and dorsal r...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2414
更新日期:2009-11-01 00:00:00
abstract::The origin of brain mechanisms that support human language-whether these originated de novo in humans or evolved from a neural substrate that existed in a common ancestor-remains a controversial issue. Although the answer is not provided by the fossil record, it is possible to make inferences by studying living specie...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1741
更新日期:2006-08-01 00:00:00
abstract::It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to m...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4068
更新日期:2015-09-01 00:00:00
abstract::Repeated cocaine administration increases the dendritic arborization of nucleus accumbens neurons, but the underlying signaling events remain unknown. Here we show that repeated exposure to cocaine negatively regulates the active form of Rac1, a small GTPase that controls actin remodeling in other systems. Further, we...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3094
更新日期:2012-06-01 00:00:00
abstract::In the postnatal subventricular zone (SVZ), local cues or signaling molecules released from neuroblasts limit the proliferation of glial fibrillary acidic protein (GFAP)-expressing progenitors thought to be stem cells. However, signals between SVZ cells have not been identified. We show that depolarization of neurobla...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1522
更新日期:2005-09-01 00:00:00
abstract::The ventral intraparietal area (VIP) receives converging inputs from visual, somatosensory, auditory and vestibular systems that use diverse reference frames to encode sensory information. A key issue is how VIP combines those inputs together. We mapped the visual and tactile receptive fields of multimodal VIP neurons...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1480
更新日期:2005-07-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-020-0595-9
更新日期:2020-02-01 00:00:00
abstract::Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3051
更新日期:2012-02-26 00:00:00
abstract::Human observers adapted to complex biological motions that distinguish males from females: viewing the gait of one gender biased judgments of subsequent gaits toward the opposite gender. This adaptation was not simply due to local features of the stimuli but instead relied upon the global motion of the figures. These ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1710
更新日期:2006-06-01 00:00:00
abstract::Neurobiological theories of knowledge processing are biased toward the language-dominant (usually the left) hemisphere. Does the right hemisphere critically contribute to knowledge processing? J.A. is a left-hemisphere language-dominant individual who suffered a lesion confined to the right mid- and anterior fusiform ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1721
更新日期:2006-07-01 00:00:00
abstract::Adult expertise in face processing is mediated largely by neural networks in the right hemisphere. Here we evaluate the contribution of early visual input in establishing this neural substrate. We compared visually normal individuals to patients for whom visual input had been restricted mainly to one hemisphere during...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1121
更新日期:2003-10-01 00:00:00
abstract::An action may lead to either a reward or a punishment. Therefore, an appropriate action needs to be chosen on the basis of the values of both expected rewards and expected punishments. To understand the underlying neural mechanisms, we conditioned monkeys using a Pavlovian procedure with two distinct contexts: one in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2233
更新日期:2009-01-01 00:00:00
abstract::The retina of warm-blooded vertebrates is believed to be incapable of neural regeneration. Here we provide evidence that the retina of postnatal chickens has the potential to generate new neurons. In response to acute damage, numerous Müller glia re-entered the cell cycle, and shortly thereafter, expressed CASH-1, Pax...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/85090
更新日期:2001-03-01 00:00:00
abstract::Fast desensitization is an important regulatory mechanism of neuronal NMDA receptor function. Only recombinant NMDA receptors composed of NR1/NR2A exhibit a fast component of desensitization similar to neuronal NMDA receptors. Here we report that the fast desensitization of NR1/NR2A receptors is caused by ambient zinc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn0901-894
更新日期:2001-09-01 00:00:00
abstract::In the version of this article initially published online, the accession code was given as GSE1000333. The correct code is GSE100033. The error has been corrected in the print, HTML and PDF versions of the article. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-018-0114-4
更新日期:2018-07-01 00:00:00
abstract::Dot patterns sliding transparently across one another are normally perceived as independently moving surfaces. Recordings from direction-selective neurons in area MT of the macaque suggested that this perceptual segregation did not depend on the presence of two peaks in the population activity. Rather, the visual syst...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/72985
更新日期:2000-03-01 00:00:00
abstract::The neurotransmitter acetylcholine (ACh) has a crucial role in central and neuromuscular synapses of the cholinergic system. After release into the synaptic cleft, ACh is rapidly degraded by acetylcholinesterase (AChE). We have identified a mutation in the ache gene of the zebrafish, which abolishes ACh hydrolysis in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn788
更新日期:2002-02-01 00:00:00
abstract::Neuroscience seeks to understand how neural circuits lead to behavior. However, the gap between circuits and behavior is too wide. An intermediate level is one of neural computations, which occur in individual neurons and populations of neurons. Some computations seem to be canonical: repeated and combined in differen...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3043
更新日期:2012-03-27 00:00:00
abstract::Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known neurofilament-dependent slowing of axonal transport, combined with the prominent misaccumulation of neurofilaments in ALS, su...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/4553
更新日期:1999-01-01 00:00:00
abstract::Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4393
更新日期:2016-11-01 00:00:00
abstract::Microglia, the brain's intrinsic immune cells, rapidly sense brain injury and help clear cellular debris. Haynes et al. now show that P2Y12 receptors are critical for activating microglia and directing them to the site of injury. ...
journal_title:Nature neuroscience
pub_type: 评论,杂志文章
doi:10.1038/nn1206-1463
更新日期:2006-12-01 00:00:00