Abstract:
:Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Girardeau G,Benchenane K,Wiener SI,Buzsáki G,Zugaro MBdoi
10.1038/nn.2384subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1222-3issue
10eissn
1097-6256issn
1546-1726pii
nn.2384journal_volume
12pub_type
杂志文章abstract::Entorhinal grid cells in mammals fire as a function of animal location, with spatially periodic response patterns. This nonlocal periodic representation of location, a local variable, is unlike other neural codes. There is no theoretical explanation for why such a code should exist. We examined how accurately the grid...
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abstract::Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers...
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abstract::Though motor neurons selectively degenerate in amyotrophic lateral sclerosis, other cell types are likely involved in this disease. We recently generated rNLS8 mice in which human TDP-43 (hTDP-43) pathology could be reversibly induced in neurons and expected that microglia would contribute to neurodegeneration. Howeve...
journal_title:Nature neuroscience
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更新日期:2018-03-01 00:00:00
abstract::The growth of neurites (axon and dendrite) should be appropriately regulated by their interactions in the development of nervous systems where a myriad of neurons and their neurites are tightly packed. We show here that mammalian seven-pass transmembrane cadherins Celsr2 and Celsr3 are activated by their homophilic in...
journal_title:Nature neuroscience
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journal_title:Nature neuroscience
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
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abstract::Adult expertise in face processing is mediated largely by neural networks in the right hemisphere. Here we evaluate the contribution of early visual input in establishing this neural substrate. We compared visually normal individuals to patients for whom visual input had been restricted mainly to one hemisphere during...
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更新日期:2013-02-01 00:00:00
abstract::Dendritic spines are motile structures that contain high concentrations of filamentous actin. Using hippocampal neurons expressing fluorescent actin and the method of fluorescence recovery after photobleaching, we found that 85 +/- 2% of actin in the spine was dynamic, with a turnover time of 44.2 +/- 4.0 s. The rapid...
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