Abstract:
:The growth of neurites (axon and dendrite) should be appropriately regulated by their interactions in the development of nervous systems where a myriad of neurons and their neurites are tightly packed. We show here that mammalian seven-pass transmembrane cadherins Celsr2 and Celsr3 are activated by their homophilic interactions and regulate neurite growth in an opposing manner. Both gene-silencing and coculture assay with rat neuron cultures showed that Celsr2 enhanced neurite growth, whereas Celsr3 suppressed it, and that their opposite functions were most likely the result of a difference of a single amino acid residue in the transmembrane domain. Together with calcium imaging and pharmacological analyses, our results suggest that Celsr2 and Celsr3 fulfill their functions through second messengers, and that differences in the activities of the homologs results in opposite effects in neurite growth regulation.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Shima Y,Kawaguchi SY,Kosaka K,Nakayama M,Hoshino M,Nabeshima Y,Hirano T,Uemura Tdoi
10.1038/nn1933subject
Has Abstractpub_date
2007-08-01 00:00:00pages
963-9issue
8eissn
1097-6256issn
1546-1726pii
nn1933journal_volume
10pub_type
杂志文章abstract::At glutamatergic synapses, calcium influx through NMDA receptors (NMDARs) is required for long-term potentiation (LTP); this is a proposed cellular mechanism underlying memory and learning. Here we show that in lateral amygdala pyramidal neurons, SK channels are also activated by calcium influx through synaptically ac...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1450
更新日期:2005-05-01 00:00:00
abstract::Information analysis shows that face-selective neurons in inferior temporal cortex encode different stimulus attributes early and late in their response to the same image. ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/13149
更新日期:1999-10-01 00:00:00
abstract::Ample evidence suggests that primary visual cortex is involved in the perception of form, and there is increasing evidence that it may also be important in the perception of surfaces. Perceptual qualities of surfaces, such as brightness, are based on extensive integration of information throughout the visual field. In...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/2849
更新日期:1998-11-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs), negative regulators of neural determination in the early embryo, were found to be potent inhibitors of neurogenesis in olfactory epithelium (OE) cultures. BMPs 2, 4 or 7 decreased the number of proliferating progenitor cells and blocked production of olfactory receptor neurons (ORNs...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/7251
更新日期:1999-04-01 00:00:00
abstract::Synaptic cadherin adhesion complexes are known to be key regulators of synapse plasticity. However, the molecular mechanisms that coordinate activity-induced modifications in cadherin localization and adhesion and the subsequent changes in synapse morphology and efficacy remain unknown. We demonstrate that the intrace...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3657
更新日期:2014-04-01 00:00:00
abstract::Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein) function, gene regulation and neuron survival. Calcium entry through synaptic NMDA receptors induced CREB activity and brain-derived neurotrophic factor (BDNF) gene...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn835
更新日期:2002-05-01 00:00:00
abstract::It is unclear how knowledge of one's actions and one's body contribute to the understanding of others' actions. Here we show that two subjects lacking cutaneous touch and sense of movement and position show a selective deficit in interpreting another person's anticipation of weight when seeing him lifting boxes. We su...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1535
更新日期:2005-10-01 00:00:00
abstract::Age-related decreases in neural function result in part from alterations in synapses. To identify molecular defects that lead to such changes, we focused on the outer retina, in which synapses are markedly altered in old rodents and humans. We found that the serine/threonine kinase LKB1 and one of its substrates, AMPK...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3772
更新日期:2014-09-01 00:00:00
abstract::The origin of brain mechanisms that support human language-whether these originated de novo in humans or evolved from a neural substrate that existed in a common ancestor-remains a controversial issue. Although the answer is not provided by the fossil record, it is possible to make inferences by studying living specie...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1741
更新日期:2006-08-01 00:00:00
abstract::Communication plays an integral role in human social dynamics and is impaired in several neurodevelopmental disorders. Mice are used to study the neurobiology of social behavior; however, the extent to which mouse vocalizations influence social dynamics has remained elusive because it is difficult to identify the voca...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-0584-z
更新日期:2020-03-01 00:00:00
abstract::Visual information is delivered to the brain by >40 types of retinal ganglion cells (RGCs). Diversity in this representation arises within the inner plexiform layer (IPL), where dendrites of each RGC type are restricted to specific sublaminae, limiting the interneuronal types that can innervate them. How such dendriti...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0127-z
更新日期:2018-05-01 00:00:00
abstract::Precise apposition of pre- to postsynaptic specializations is required for optimal function of chemical synapses, but little is known about how it is achieved. At the skeletal neuromuscular junction, active zones (transmitter release sites) in the nerve terminal lie directly opposite junctional folds in the postsynapt...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/88414
更新日期:2001-06-01 00:00:00
abstract::Temporal and quantitative relations between excitatory and inhibitory inputs in the cortex are central to its activity, yet they remain poorly understood. In particular, a controversy exists regarding the extent of correlation between cortical excitation and inhibition. Using simultaneous intracellular recordings in p...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2105
更新日期:2008-05-01 00:00:00
abstract::When sleep followed implicit training on a motor sequence, children showed greater gains in explicit sequence knowledge after sleep than adults. This greater explicit knowledge in children was linked to their higher sleep slow-wave activity and to stronger hippocampal activation at explicit knowledge retrieval. Our da...
journal_title:Nature neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1038/nn.3343
更新日期:2013-04-01 00:00:00
abstract::The processing of synaptic potentials by neuronal dendrites depends on both their passive cable properties and active voltage-gated channels, which can generate complex effects as a result of their nonlinear properties. We characterized the actions of HCN (hyperpolarization-activated cyclic nucleotide-gated cation) ch...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2307
更新日期:2009-05-01 00:00:00
abstract::Psychiatric morbidity is high in cities, so identifying potential modifiable urban protective factors is important. We show that exposure to urban green space improves well-being in naturally behaving male and female city dwellers, particularly in districts with higher psychiatric incidence and fewer green resources. ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0451-y
更新日期:2019-09-01 00:00:00
abstract::Humans and other primates sample the visual environment using saccadic eye movements that shift a high-resolution fovea toward regions of interest to create a clear perception of a scene across fixations. Many mammals, however, like mice, lack a fovea, which raises the question of why they make saccades. Here we descr...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0255-5
更新日期:2018-11-01 00:00:00
abstract::EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly. In addition, given that EphBs signal through multiple mechanisms, it has been challenging to define which signaling fun...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3249
更新日期:2012-12-01 00:00:00
abstract::The music faculty is not a monolithic entity that a person either has or does not. Rather, it comprises a set of neurally isolable processing components, each having the potential to be specialized for music. Here we propose a functional architecture for music processing that captures the typical properties of modular...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn1083
更新日期:2003-07-01 00:00:00
abstract::Active dendritic integration is thought to enrich the computational power of central neurons. However, a direct role of active dendritic processing in the execution of defined neuronal computations in intact neural networks has not been established. Here we used multi-site electrophysiological recording techniques to ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3565
更新日期:2013-12-01 00:00:00
abstract::Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency-modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally i...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2239
更新日期:2009-01-01 00:00:00
abstract::Robust form perception and underlying neuronal mechanisms require generalized representation of object boundaries, independent of how they are defined. One visual ability essential for form perception is reconstruction of contours absent from the retinal image. Here we show that barn owls perceive subjective contours ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/10217
更新日期:1999-07-01 00:00:00
abstract::During development and aging and in amblyopia, visual acuity is far below the limitations set by the retina. Expression of brain-derived neurotrophic factor (BDNF) in the visual cortex is reduced in these situations. We asked whether neurotrophic tyrosine kinase receptor, type 2 (TrkB) regulates cortical visual acuity...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2534
更新日期:2010-05-01 00:00:00
abstract::Retinal bipolar cells have been assumed to generate purely graded responses to light. To test this idea we imaged the presynaptic calcium transient in live zebrafish. We found that ON, OFF, transient and sustained bipolar cells are all capable of generating fast 'all-or-none' calcium transients modulated by visual sti...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2841
更新日期:2011-06-26 00:00:00
abstract::Contrast is computed throughout the nervous system to encode changing inputs efficiently. The retina encodes luminance and contrast over a wide range of visual conditions and must adapt its responses to maintain sensitivity and to avoid saturation. We examined the means by which one type of adaptation allows individua...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2945
更新日期:2011-10-23 00:00:00
abstract::The structure and function of presynaptic and postsynaptic compartments varies markedly in neurons, but little is known about how they are functionally arranged with respect to each other. In rat hippocampal neurons, we found that, although they are structurally correlated from the early moments of formation, synapses...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2826
更新日期:2011-06-01 00:00:00
abstract::Communication between glia cells and neurons is crucial for brain functions, but the molecular mechanisms and functional consequences of gliotransmission remain enigmatic. Here we report that astrocytes express synaptobrevin II and cellubrevin as functionally non-overlapping vesicular SNARE proteins on glutamatergic v...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4647
更新日期:2017-11-01 00:00:00
abstract::The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. The CNS-resident immune system is comprised mainly of innate immune cells and operates under homeostatic conditions. These m...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.4475
更新日期:2017-02-01 00:00:00
abstract::Cuing covert spatial attention can increase spatial resolution. Here we pinpointed the specific locus of this effect using texture segmentation. At the level of visual cortex, texture segmentation theoretically involves passage of visual input through two layers of spatial linear filters separated by a pointwise nonli...
journal_title:Nature neuroscience
pub_type: 临床试验,杂志文章
doi:10.1038/75804
更新日期:2000-06-01 00:00:00
abstract::Although much learning occurs through direct experience of errors, humans and other animals can learn from the errors of other individuals. The medial frontal cortex (MFC) processes self-generated errors, but the neuronal architecture and mechanisms underlying the monitoring of others' errors are poorly understood. Ex...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3180
更新日期:2012-09-01 00:00:00