Expert face processing requires visual input to the right hemisphere during infancy.

abstract：:Microglia are primary immune sentinels of the CNS. Following injury, these cells migrate or extend processes toward sites of tissue damage. CNS injury is accompanied by release of nucleotides, serving as signals for microglial activation or chemotaxis. Microglia express several purinoceptors, including a G(i)-coupled ...

journal_title：Nature neuroscience

authors： Haynes SE,Hollopeter G,Yang G,Kurpius D,Dailey ME,Gan WB,Julius D

更新日期：2006-12-01 00:00:00

abstract：:Psychiatric morbidity is high in cities, so identifying potential modifiable urban protective factors is important. We show that exposure to urban green space improves well-being in naturally behaving male and female city dwellers, particularly in districts with higher psychiatric incidence and fewer green resources. ...

journal_title：Nature neuroscience

authors： Tost H,Reichert M,Braun U,Reinhard I,Peters R,Lautenbach S,Hoell A,Schwarz E,Ebner-Priemer U,Zipf A,Meyer-Lindenberg A

更新日期：2019-09-01 00:00:00

abstract：:Despite the numerous examples of anticipatory cognitive processes at micro and macro levels in many animal species, the idea that anticipation of specific words plays an integral role in real-time language processing has been contentious. Here we exploited a phonological regularity of English indefinite articles ('an'...

journal_title：Nature neuroscience

authors： DeLong KA,Urbach TP,Kutas M

更新日期：2005-08-01 00:00:00

abstract：:Neuronal signaling occurs through both action potential-triggered synaptic vesicle fusion and spontaneous release, although the fusion clamp machinery that prevents premature exocytosis of synaptic vesicles in the absence of calcium is unknown. Here we demonstrate that spontaneous release at synapses is regulated by c...

journal_title：Nature neuroscience

authors： Huntwork S,Littleton JT

更新日期：2007-10-01 00:00:00

abstract：:Memory reconsolidation has been demonstrated in various tasks and species, suggesting it is a fundamental process. However, there are experimental parameters that can inhibit reconsolidation from occurring (boundary conditions). These conditions and their mechanisms remain poorly defined. Here, we characterize the abi...

journal_title：Nature neuroscience

authors： Wang SH,de Oliveira Alvares L,Nader K

更新日期：2009-07-01 00:00:00

abstract：:Dendritic spines are motile structures that contain high concentrations of filamentous actin. Using hippocampal neurons expressing fluorescent actin and the method of fluorescence recovery after photobleaching, we found that 85 +/- 2% of actin in the spine was dynamic, with a turnover time of 44.2 +/- 4.0 s. The rapid...

journal_title：Nature neuroscience

authors： Star EN,Kwiatkowski DJ,Murthy VN

更新日期：2002-03-01 00:00:00

abstract：:The brain transforms physical sensory stimuli into meaningful perceptions. In animals making choices about sensory stimuli, neuronal activity in successive cortical stages reflects a progression from sensation to decision. Feedforward and feedback pathways connecting cortical areas are critical for this transformation...

journal_title：Nature neuroscience

authors： Kwon SE,Yang H,Minamisawa G,O'Connor DH

更新日期：2016-09-01 00:00:00

abstract：:Pain is fundamentally unpleasant, a feature that protects the organism by promoting motivation and learning. Relief of aversive states, including pain, is rewarding. The aversiveness of pain, as well as the reward from relief of pain, is encoded by brain reward/motivational mesocorticolimbic circuitry. In this Review,...

journal_title：Nature neuroscience

authors： Navratilova E,Porreca F

更新日期：2014-10-01 00:00:00

abstract：:Much of the information processing in the brain occurs at the level of local circuits; however, the mechanisms underlying their initial development are poorly understood. We sought to examine the early development and plasticity of local excitatory circuits in the optic tectum of Xenopus laevis tadpoles. We found that...

journal_title：Nature neuroscience

authors： Pratt KG,Dong W,Aizenman CD

更新日期：2008-04-01 00:00:00

abstract：:Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to ...

journal_title：Nature neuroscience

authors： Kress GJ,Yamawaki N,Wokosin DL,Wickersham IR,Shepherd GM,Surmeier DJ

更新日期：2013-06-01 00:00:00

abstract：:Odor stimulation evokes complex spatiotemporal activity in the olfactory bulb, suggesting that both the identity of activated neurons and the timing of their activity convey information about odors. However, whether and how downstream neurons decipher these temporal patterns remains unknown. We addressed this question...

journal_title：Nature neuroscience

authors： Haddad R,Lanjuin A,Madisen L,Zeng H,Murthy VN,Uchida N

更新日期：2013-07-01 00:00:00

abstract：:Exposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-associated release of noradrenaline enhances the capacity of central synapses to show plasticity (metaplasticity). We found noradrenaline-dependent metaplasticity at GABA synapses in the paraventricular nucleus of the hypot...

journal_title：Nature neuroscience

authors： Inoue W,Baimoukhametova DV,Füzesi T,Wamsteeker Cusulin JI,Koblinger K,Whelan PJ,Pittman QJ,Bains JS

更新日期：2013-05-01 00:00:00

abstract：:Dysfunction in sensory information processing is a hallmark of many neurological disorders, including autism spectrum disorders, schizophrenia and Rett syndrome (RTT). Using mouse models of RTT, a monogenic disorder caused by mutations in MECP2, we found that the large-scale loss of MeCP2 from forebrain GABAergic inte...

journal_title：Nature neuroscience

authors： Goffin D,Brodkin ES,Blendy JA,Siegel SJ,Zhou Z

更新日期：2014-06-01 00:00:00

abstract：:The olfactory system faces a hard problem: on the basis of noisy information from olfactory receptor neurons (the neurons that transduce chemicals to neural activity), it must figure out which odors are present in the world. Odors almost never occur in isolation, and different odors excite overlapping populations of o...

journal_title：Nature neuroscience

authors： Grabska-Barwińska A,Barthelmé S,Beck J,Mainen ZF,Pouget A,Latham PE

更新日期：2017-01-01 00:00:00

abstract：:Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhi...

journal_title：Nature neuroscience

authors： Couey JJ,Witoelar A,Zhang SJ,Zheng K,Ye J,Dunn B,Czajkowski R,Moser MB,Moser EI,Roudi Y,Witter MP

更新日期：2013-03-01 00:00:00

abstract：:Trafficking of AMPA receptors (AMPARs) is important for many forms of synaptic plasticity. However, the link between activity and resulting synaptic alterations is not fully understood. We identified a direct interaction between N-ethylmaleimide-sensitive fusion protein (NSF), an ATPase involved in membrane fusion eve...

journal_title：Nature neuroscience

authors： Evers DM,Matta JA,Hoe HS,Zarkowsky D,Lee SH,Isaac JT,Pak DT

更新日期：2010-10-01 00:00:00

abstract：:Synaptic stimulation activates signal transduction pathways, producing persistently active protein kinases. PKMzeta is a truncated, persistently active isoform of atypical protein kinase C-zeta (aPKCzeta), which lacks the N-terminal pseudosubstrate regulatory domain. Using a Pavlovian olfactory learning task in Drosop...

journal_title：Nature neuroscience

authors： Drier EA,Tello MK,Cowan M,Wu P,Blace N,Sacktor TC,Yin JC

更新日期：2002-04-01 00:00:00

abstract：:A hallmark of addiction is the loss of control over drug intake, which is seen in only a fraction of those exposed to stimulant drugs such as cocaine. The cellular mechanisms underlying vulnerability or resistance to compulsive drug use remain unknown. We found that individual variability in the development of highly ...

journal_title：Nature neuroscience

authors： Bock R,Shin JH,Kaplan AR,Dobi A,Markey E,Kramer PF,Gremel CM,Christensen CH,Adrover MF,Alvarez VA

更新日期：2013-05-01 00:00:00

abstract：:Transformation of mechanical energy into ionic currents is essential for touch, hearing and nociception. Although DEG/ENaC proteins are believed to form sensory mechanotransduction channels, the evidence for this role remains indirect. By recording from C. elegans touch receptor neurons in vivo, we found that external...

journal_title：Nature neuroscience

authors： O'Hagan R,Chalfie M,Goodman MB

更新日期：2005-01-01 00:00:00

abstract：:The efficiency of remyelination decreases with age, but the molecular mechanisms responsible for this decline remain only partially understood. In this study, we show that remyelination is regulated by age-dependent epigenetic control of gene expression. In demyelinated young brains, new myelin synthesis is preceded b...

journal_title：Nature neuroscience

authors： Shen S,Sandoval J,Swiss VA,Li J,Dupree J,Franklin RJ,Casaccia-Bonnefil P

更新日期：2008-09-01 00:00:00

abstract：:Sensory neural systems use spatiotemporal coding mechanisms to represent stimuli. These time-varying response patterns sometimes outlast the stimulus. Can the temporal structure of a stimulus interfere with, or even disrupt, the spatiotemporal structure of the neural representation? We investigated this potential conf...

journal_title：Nature neuroscience

authors： Brown SL,Joseph J,Stopfer M

更新日期：2005-11-01 00:00:00

abstract：:Head-direction cells have frequently been regarded as an internal 'compass' that can be used for navigation, although there is little evidence showing a link between their activity and spatial behavior. In a navigational task requiring the use of internal cues to return to a home location without vision (path integrat...

journal_title：Nature neuroscience

authors： Valerio S,Taube JS

更新日期：2012-10-01 00:00:00

abstract：:An ion channel's function depends largely on its location and density on neurons. Here we used high-resolution immunolocalization to determine the subcellular distribution of the hyperpolarization-activated and cyclic-nucleotide-gated channel subunit 1 (HCN1) in rat brain. Light microscopy revealed graded HCN1 immunor...

journal_title：Nature neuroscience

authors： Lörincz A,Notomi T,Tamás G,Shigemoto R,Nusser Z

更新日期：2002-11-01 00:00:00

abstract：:The precise period when experience shapes neural circuits in the mouse visual system is unknown. We used Arc induction to monitor the functional pattern of ipsilateral eye representation in cortex during normal development and after visual deprivation. After monocular deprivation during the critical period, Arc induct...

journal_title：Nature neuroscience

authors： Tagawa Y,Kanold PO,Majdan M,Shatz CJ

更新日期：2005-03-01 00:00:00

abstract：:Here, we characterized behavioral abnormalities induced by prolonged social isolation in adult rodents. Social isolation induced both anxiety- and anhedonia-like symptoms and decreased cAMP response element-binding protein (CREB) activity in the nucleus accumbens shell (NAcSh). All of these abnormalities were reversed...

journal_title：Nature neuroscience

authors： Wallace DL,Han MH,Graham DL,Green TA,Vialou V,Iñiguez SD,Cao JL,Kirk A,Chakravarty S,Kumar A,Krishnan V,Neve RL,Cooper DC,Bolaños CA,Barrot M,McClung CA,Nestler EJ

更新日期：2009-02-01 00:00:00

abstract：:Entorhinal grid cells in mammals fire as a function of animal location, with spatially periodic response patterns. This nonlocal periodic representation of location, a local variable, is unlike other neural codes. There is no theoretical explanation for why such a code should exist. We examined how accurately the grid...

journal_title：Nature neuroscience

authors： Sreenivasan S,Fiete I

更新日期：2011-09-11 00:00:00

abstract：:The molecular organization of presynaptic active zones is important for the neurotransmitter release that is triggered by depolarization-induced Ca2+ influx. Here, we demonstrate a previously unknown interaction between two components of the presynaptic active zone, RIM1 and voltage-dependent Ca2+ channels (VDCCs), th...

journal_title：Nature neuroscience

authors： Kiyonaka S,Wakamori M,Miki T,Uriu Y,Nonaka M,Bito H,Beedle AM,Mori E,Hara Y,De Waard M,Kanagawa M,Itakura M,Takahashi M,Campbell KP,Mori Y

更新日期：2007-06-01 00:00:00

abstract：:Human behavior is mostly composed of habitual actions that require little conscious control. Such actions may become invalid if the environment changes, at which point individuals need to switch behavior by overcoming habitual actions that are otherwise triggered automatically. It is unknown how the brain controls thi...

journal_title：Nature neuroscience

authors： Isoda M,Hikosaka O

更新日期：2007-02-01 00:00:00

abstract：:Chronic morphine exposure upregulates adenylate cyclase signaling and reduces analgesic efficacy, a condition known as opioid tolerance. Nonopioid neurotransmitters can enhance morphine tolerance, but the mechanism for this is poorly understood. We show that morphine tolerance was delayed in mice lacking vasopressin 1...

journal_title：Nature neuroscience

authors： Koshimizu TA,Honda K,Nagaoka-Uozumi S,Ichimura A,Kimura I,Nakaya M,Sakai N,Shibata K,Ushijima K,Fujimura A,Hirasawa A,Kurose H,Tsujimoto G,Tanoue A,Takano Y

更新日期：2018-06-01 00:00:00

abstract：:The diseased brain hosts a heterogeneous population of myeloid cells, including parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne monocytes. To date, the different types of brain myeloid cells have been discriminated solely on the basis of their localization, morphology and surface epito...

journal_title：Nature neuroscience

authors： Prinz M,Priller J,Sisodia SS,Ransohoff RM

更新日期：2011-09-27 00:00:00