Abstract：
:Neuronal signaling occurs through both action potential-triggered synaptic vesicle fusion and spontaneous release, although the fusion clamp machinery that prevents premature exocytosis of synaptic vesicles in the absence of calcium is unknown. Here we demonstrate that spontaneous release at synapses is regulated by complexin, a SNARE complex-binding protein. Analysis of Drosophila melanogaster complexin null mutants showed a marked increase in spontaneous fusion and a profound overgrowth of synapses, suggesting that complexin functions as the fusion clamp in vivo and may modulate structural remodeling of neuronal connections by controlling the rate of spontaneous release.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Huntwork S,Littleton JTdoi
10.1038/nn1980subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1235-7issue
10eissn
1097-6256issn
1546-1726pii
nn1980journal_volume
10pub_type
杂志文章abstract：:Histone deacetylases (HDACs) are major epigenetic regulators. We show that HDAC1 and HDAC2 functions are critical for myelination of the peripheral nervous system. Using mouse genetics, we have ablated Hdac1 and Hdac2 specifically in Schwann cells, resulting in massive Schwann cell loss and virtual absence of myelin i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2762
更新日期：2011-04-01 00:00:00
abstract：:High and low spatial frequency information in visual images is processed by distinct neural channels. Using event-related functional magnetic resonance imaging (fMRI) in humans, we show dissociable roles of such visual channels for processing faces and emotional fearful expressions. Neural responses in fusiform cortex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1057
更新日期：2003-06-01 00:00:00
abstract：:Lateral and medial parts of entorhinal cortex (EC) convey nonspatial 'what' and spatial 'where' information, respectively, into hippocampal CA1, via both the indirect EC layer 2→ hippocampal dentate gyrus→CA3→CA1 and the direct EC layer 3→CA1 paths. However, it remains elusive how the direct path transfers distinct in...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4517
更新日期：2017-04-01 00:00:00
abstract：:The identification of distinct cell types in the basal ganglia has been critical to our understanding of basal ganglia function and the treatment of neurological disorders. The external globus pallidus (GPe) is a key contributor to motor suppressing pathways in the basal ganglia, yet its neuronal heterogeneity has rem...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4559
更新日期：2017-06-01 00:00:00
abstract：:Contrast is computed throughout the nervous system to encode changing inputs efficiently. The retina encodes luminance and contrast over a wide range of visual conditions and must adapt its responses to maintain sensitivity and to avoid saturation. We examined the means by which one type of adaptation allows individua...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2945
更新日期：2011-10-23 00:00:00
abstract：:A decade after speech was first decoded from human brain signals, accuracy and speed remain far below that of natural speech. Here we show how to decode the electrocorticogram with high accuracy and at natural-speech rates. Taking a cue from recent advances in machine translation, we train a recurrent neural network t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0608-8
更新日期：2020-04-01 00:00:00
abstract：:The C. elegans SAX-3/Robo receptor acts in anterior-posterior, dorsal-ventral and midline guidance decisions. Here we show that SAX-3 signaling involves the C. elegans Enabled protein UNC-34 and an unexpected Netrin-independent function of the Netrin receptor UNC-40/DCC. Genetic interactions with gain- and loss-of-fun...
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journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/82947
更新日期：2001-01-01 00:00:00
abstract：:Transmitter release is triggered by highly localized, transient increases in the presynaptic Ca(2+) concentration ([Ca(2+)]). Rapidly decaying [Ca(2+)] elevations were generated using Ca(2+) uncaging techniques, and [Ca(2+)] was measured with a low-affinity Ca(2+) indicator in a giant presynaptic terminal, the calyx o...
journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2005-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/s41593-018-0287-x
更新日期：2019-01-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2015-04-01 00:00:00
abstract：:Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylat...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1023
更新日期：2003-04-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0094-4
更新日期：2018-04-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
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更新日期：2000-06-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章,评审
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/16046
更新日期：1999-12-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2015-04-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4186
更新日期：2016-01-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 评论,杂志文章,评审
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
abstract：:We used ultrasound image-guided injections of high-titer retroviral vectors to obtain widespread introduction of genes into the mouse nervous system in utero as early as embryonic day 8.5 (E8.5). The vectors used included internal promoters that substantially improved proviral gene expression in the ventricular zone o...
journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：1999-09-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1377
更新日期：2005-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1338
更新日期：2004-11-01 00:00:00
abstract：:The molecular organization of presynaptic active zones is important for the neurotransmitter release that is triggered by depolarization-induced Ca2+ influx. Here, we demonstrate a previously unknown interaction between two components of the presynaptic active zone, RIM1 and voltage-dependent Ca2+ channels (VDCCs), th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1904
更新日期：2007-06-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.2273
更新日期：2009-04-01 00:00:00
