Abstract：
:An ion channel's function depends largely on its location and density on neurons. Here we used high-resolution immunolocalization to determine the subcellular distribution of the hyperpolarization-activated and cyclic-nucleotide-gated channel subunit 1 (HCN1) in rat brain. Light microscopy revealed graded HCN1 immunoreactivity in apical dendrites of hippocampal, subicular and neocortical layer-5 pyramidal cells. Quantitative comparison of immunogold densities showed a 60-fold increase from somatic to distal apical dendritic membranes. Distal dendritic shafts had 16 times more HCN1 labeling than proximal dendrites of similar diameters. At the same distance from the soma, the density of HCN1 was significantly higher in dendritic shafts than in spines. Our results reveal the complex cell surface distribution of voltage-gated ion-channels, and predict its role in increasing the computational power of single neurons via subcellular domain and input-specific mechanisms.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Lörincz A,Notomi T,Tamás G,Shigemoto R,Nusser Zdoi
10.1038/nn962subject
Has Abstractpub_date
2002-11-01 00:00:00pages
1185-93issue
11eissn
1097-6256issn
1546-1726pii
nn962journal_volume
5pub_type
杂志文章abstract：:Transcriptomic analyses of postmortem brains have begun to elucidate molecular abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in synaptic development, RNA editing, has not yet been studied on a genome-wide scale. Here we profiled global patterns of adenosine-to-inosine (A-to-I) ed...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0287-x
更新日期：2019-01-01 00:00:00
abstract：:Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3051
更新日期：2012-02-26 00:00:00
abstract：:The distinct electrical properties of axonal and dendritic membranes are largely a result of specific transport of vesicle-bound membrane proteins to each compartment. How this specificity arises is unclear because kinesin motors that transport vesicles cannot autonomously distinguish dendritically projecting microtub...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2318
更新日期：2009-05-01 00:00:00
abstract：:The primate superior colliculus (SC) is a midbrain nucleus crucial for the control of rapid eye movements (saccades). Its neurons are topographically arranged over the rostrocaudal and mediolateral extent of its deeper layers so that saccade metrics (amplitude and direction) are coded in terms of the location of activ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn727
更新日期：2001-10-01 00:00:00
abstract：:A decade after speech was first decoded from human brain signals, accuracy and speed remain far below that of natural speech. Here we show how to decode the electrocorticogram with high accuracy and at natural-speech rates. Taking a cue from recent advances in machine translation, we train a recurrent neural network t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0608-8
更新日期：2020-04-01 00:00:00
abstract：:Neurobiological theories of knowledge processing are biased toward the language-dominant (usually the left) hemisphere. Does the right hemisphere critically contribute to knowledge processing? J.A. is a left-hemisphere language-dominant individual who suffered a lesion confined to the right mid- and anterior fusiform ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1721
更新日期：2006-07-01 00:00:00
abstract：:Synaptic strength can be altered by a variety of pre- or postsynaptic modifications. Here we test the hypothesis that long-term depression (LTD) involves a decrease in the number of glutamate receptors that are clustered at individual synapses in primary cultures of hippocampal neurons. Similar to a prominent form of ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/8123
更新日期：1999-05-01 00:00:00
abstract：:Previous gene knockout studies have shown that the orphan glutamate receptor delta2 (GluRdelta2) is critically involved in synaptogenesis between parallel fibers and Purkinje cells during development. However, the precise function of GluRdelta2 and whether it is functional in the mature cerebellum remain unclear. To a...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1086
更新日期：2003-08-01 00:00:00
abstract：:Cue-triggered recall of learned temporal sequences is an important cognitive function that has been attributed to higher brain areas. Here recordings in both anesthetized and awake rats demonstrate that after repeated stimulation with a moving spot that evoked sequential firing of an ensemble of primary visual cortex ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3036
更新日期：2012-01-22 00:00:00
abstract：:An action may lead to either a reward or a punishment. Therefore, an appropriate action needs to be chosen on the basis of the values of both expected rewards and expected punishments. To understand the underlying neural mechanisms, we conditioned monkeys using a Pavlovian procedure with two distinct contexts: one in ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2233
更新日期：2009-01-01 00:00:00
abstract：:Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylat...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1023
更新日期：2003-04-01 00:00:00
abstract：:Interleukin 17 (IL-17) is a signature cytokine of Th17 cells. We previously reported that deletion of NF-κB activator 1 (Act1), the key transducer of IL-17 receptor signaling, from the neuroectodermal lineage in mice (neurons, oligodendrocytes and astrocytes) results in attenuated severity of experimental autoimmune e...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3505
更新日期：2013-10-01 00:00:00
abstract：:Despite the importance of neuropeptide release, which is evoked by long bouts of action potential activity and which regulates behavior, peptidergic vesicle movement has not been examined in living nerve terminals. Previous in vitro studies have found that secretory vesicle motion at many sites of release is constitut...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1377
更新日期：2005-02-01 00:00:00
abstract：:In the nose, odorants are detected on the cilia of olfactory sensory neurons (OSNs), where a cAMP-mediated signaling pathway transforms odor stimulation into electrical responses. Phosphodiesterase (PDE) activity in OSN cilia has long been thought to account for rapid response termination by degrading odor-induced cAM...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2289
更新日期：2009-04-01 00:00:00
abstract：:Cuing covert spatial attention can increase spatial resolution. Here we pinpointed the specific locus of this effect using texture segmentation. At the level of visual cortex, texture segmentation theoretically involves passage of visual input through two layers of spatial linear filters separated by a pointwise nonli...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/75804
更新日期：2000-06-01 00:00:00
abstract：:Humans, and animals, often encounter ambiguous situations that require a decision on whether to take an offense or a defense strategy. Behavioral studies suggest that a strategy decision is frequently made before concrete options are evaluated. It remains enigmatic, however, how a strategy is determined without explor...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3999
更新日期：2015-05-01 00:00:00
abstract：:Animals strategically scan the environment to form an accurate perception of their surroundings. Here we investigated the neuronal representations that mediate this behavior. Ca2+ imaging and selective optogenetic manipulation during an active sensing task reveals that layer 5 pyramidal neurons in the vibrissae cortex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0254-6
更新日期：2018-11-01 00:00:00
abstract：:Increases in dopamine and glutamate transmission in the nucleus accumbens independently promote the reinstatement of cocaine seeking, an animal model of relapse. Here we have tested whether cocaine reinstatement in rats depends on interactions between accumbal dopamine and glutamate systems that are mediated by Ca(2+)...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn2054
更新日期：2008-03-01 00:00:00
abstract：:Humans have ~400 intact odorant receptors, but each individual has a unique set of genetic variations that lead to variation in olfactory perception. We used a heterologous assay to determine how often genetic polymorphisms in odorant receptors alter receptor function. We identified agonists for 18 odorant receptors a...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3598
更新日期：2014-01-01 00:00:00
abstract：:Memory is supported by a specific ensemble of neurons distributed in the brain that form a unique memory trace. We previously showed that neurons in the lateral amygdala expressing elevated levels of cAMP response-element binding protein are preferentially recruited into fear memory traces and are necessary for the ex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3592
更新日期：2014-01-01 00:00:00
abstract：:In the version of this article initially published, the annotation accompanying ref. 47 ended with "though the modulation of microglia." The first word of this phrase should have been "through." The error has been corrected in the HTML and PDF versions of the article. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0186-1
更新日期：2018-08-01 00:00:00
abstract：:En route to their target, pioneering motor growth cones repeatedly encounter choice points at which they make pathway decisions. In the zebrafish mutant unplugged, two of the three segmental motor axons make incorrect decisions at a somitic choice point. Using positional cloning, we show here that unplugged encodes a ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1350
更新日期：2004-12-01 00:00:00
abstract：:A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1593
更新日期：2006-01-01 00:00:00
abstract：:We argue that there will be no single (genetic or cognitive) cause for the diverse symptoms defining autism. We present recent evidence of behavioral fractionation of social impairment, communication difficulties and rigid and repetitive behaviors. Twin data suggest largely nonoverlapping genes acting on each of these...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn1770
更新日期：2006-10-01 00:00:00
abstract：:Most neurons receive thousands of synaptic inputs onto widely spread dendrites. Because of dendritic filtering, distant synapses should have less efficacy than proximal ones. To investigate this, we characterized the amplitude and kinetics of excitatory synaptic input across the apical dendrites of CA1 pyramidal neuro...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/78800
更新日期：2000-09-01 00:00:00
abstract：:The subunit composition of postsynaptic non-NMDA-type glutamate receptors (GluRs) determines the function and trafficking of the receptor. Changes in GluR composition have been implicated in the homeostasis of neuronal excitability and synaptic plasticity underlying learning. Here, we imaged GluRs in vivo during the f...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2122
更新日期：2008-06-01 00:00:00
abstract：:Replay of hippocampal place cell sequences has been proposed as a fundamental mechanism of learning and memory. However, the standard interpretation of replay has been challenged by reports that similar activity is observed before experience ('preplay'). By the preplay account, pre-existing temporal sequences are mapp...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4151
更新日期：2015-12-01 00:00:00
abstract：:Breathing is a bilaterally synchronous behavior that relies on a respiratory rhythm generator located in the brainstem. An essential component of this generator is the preBötzinger complex (preBötC), which paces inspirations. Little is known about the developmental origin of the interneuronal populations forming the p...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2622
更新日期：2010-09-01 00:00:00
abstract：:Dysfunction in sensory information processing is a hallmark of many neurological disorders, including autism spectrum disorders, schizophrenia and Rett syndrome (RTT). Using mouse models of RTT, a monogenic disorder caused by mutations in MECP2, we found that the large-scale loss of MeCP2 from forebrain GABAergic inte...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3710
更新日期：2014-06-01 00:00:00
abstract：:We report on two brain-damaged subjects who exhibit the uncommon pattern of loss of object color knowledge, but spared color perception and naming. The subject P.C.O., as in previously reported patients, is also impaired in processing other perceptual and functional properties of objects. I.O.C., in contrast, is the f...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/88497
更新日期：2001-06-01 00:00:00
