Abstract:
:The diseased brain hosts a heterogeneous population of myeloid cells, including parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne monocytes. To date, the different types of brain myeloid cells have been discriminated solely on the basis of their localization, morphology and surface epitope expression. However, recent data suggest that resident microglia may be functionally distinct from bone marrow- or blood-derived phagocytes, which invade the CNS under pathological conditions. During the last few years, research on brain myeloid cells has been markedly changed by the advent of new tools in imaging, genetics and immunology. These methodologies have yielded unexpected results, which challenge the traditional view of brain macrophages. On the basis of these new studies, we differentiate brain myeloid subtypes with regard to their origin, function and fate in the brain and illustrate the divergent features of these cells during neurodegeneration.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Prinz M,Priller J,Sisodia SS,Ransohoff RMdoi
10.1038/nn.2923subject
Has Abstractpub_date
2011-09-27 00:00:00pages
1227-35issue
10eissn
1097-6256issn
1546-1726pii
nn.2923journal_volume
14pub_type
杂志文章,评审abstract::Spillover of glutamate under physiological conditions has only been established as an adjunct to conventional synaptic transmission. Here we describe a pure spillover connection between the climbing fiber and molecular layer interneurons in the rat cerebellar cortex. We show that, instead of acting via conventional sy...
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pub_type: 评论,杂志文章
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journal_title:Nature neuroscience
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更新日期:2010-09-01 00:00:00
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pub_type: 已发布勘误
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