Abstract：
:In the nose, odorants are detected on the cilia of olfactory sensory neurons (OSNs), where a cAMP-mediated signaling pathway transforms odor stimulation into electrical responses. Phosphodiesterase (PDE) activity in OSN cilia has long been thought to account for rapid response termination by degrading odor-induced cAMP. Two PDEs with distinct cellular localization have been found in OSNs: PDE1C in the cilia and PDE4A throughout the cell but absent from the cilia. We disrupted both of these genes in mice and carried out electro-olfactogram analysis. Unexpectedly, eliminating PDE1C did not prolong response termination. Prolonged termination occurred only in mice that lacked both PDEs, suggesting that cAMP degradation by PDE1C in cilia is not a rate-limiting factor for response termination in wild-type mice. Pde1c(-/-) OSNs instead showed reduced sensitivity and attenuated adaptation to repeated stimulation, suggesting that PDE1C may be involved in regulating sensitivity and adaptation. Our observations provide new perspectives on the regulation of olfactory transduction.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Cygnar KD,Zhao Hdoi
10.1038/nn.2289subject
Has Abstractpub_date
2009-04-01 00:00:00pages
454-62issue
4eissn
1097-6256issn
1546-1726pii
nn.2289journal_volume
12pub_type
杂志文章abstract：:Humans have ~400 intact odorant receptors, but each individual has a unique set of genetic variations that lead to variation in olfactory perception. We used a heterologous assay to determine how often genetic polymorphisms in odorant receptors alter receptor function. We identified agonists for 18 odorant receptors a...
journal_title：Nature neuroscience
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更新日期：2010-02-01 00:00:00
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pub_type： 已发布勘误
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更新日期：2011-09-27 00:00:00
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更新日期：2003-08-01 00:00:00
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更新日期：2002-08-01 00:00:00
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更新日期：2007-02-01 00:00:00
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更新日期：1998-05-01 00:00:00
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