Abstract：
:Selective attention filters information to limit what is encoded and maintained in working memory. Although the prefrontal cortex (PFC) is central to both selective attention and working memory, the underlying neural processes that link these cognitive abilities remain elusive. Using functional magnetic resonance imaging to guide repetitive transcranial magnetic stimulation with electroencephalographic recordings in humans, we perturbed PFC function at the inferior frontal junction in participants before they performed a selective-attention, delayed-recognition task. This resulted in diminished top-down modulation of activity in posterior cortex during early encoding stages, which predicted a subsequent decrement in working memory accuracy. Participants with stronger fronto-posterior functional connectivity displayed greater disruptive effects. Our data further suggests that broad alpha-band (7-14 Hz) phase coherence subserved this long-distance top-down modulation. These results suggest that top-down modulation mediated by the prefrontal cortex is a causal link between early attentional processes and subsequent memory performance.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Zanto TP,Rubens MT,Thangavel A,Gazzaley Adoi
10.1038/nn.2773subject
Has Abstractpub_date
2011-05-01 00:00:00pages
656-61issue
5eissn
1097-6256issn
1546-1726pii
nn.2773journal_volume
14pub_type
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