Continuous shifts in the active set of spinal interneurons during changes in locomotor speed.


:The classic 'size principle' of motor control describes how increasingly forceful movements arise by the recruitment of motoneurons of progressively larger size and force output into the active pool. We explored the activity of pools of spinal interneurons in larval zebrafish and found that increases in swimming speed were not associated with the simple addition of cells to the active pool. Instead, the recruitment of interneurons at faster speeds was accompanied by the silencing of those driving movements at slower speeds. This silencing occurred both between and within classes of rhythmically active premotor excitatory interneurons. Thus, unlike motoneurons, there is a continuous shift in the set of cells driving the behavior, even though changes in the speed of the movements and the frequency of the motor pattern appear to be smoothly graded. We conclude that fundamentally different principles may underlie the recruitment of motoneuron and interneuron pools.


Nat Neurosci


Nature neuroscience


McLean DL,Masino MA,Koh IY,Lindquist WB,Fetcho JR




Has Abstract


2008-12-01 00:00:00














  • Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster.

    abstract::Synaptic stimulation activates signal transduction pathways, producing persistently active protein kinases. PKMzeta is a truncated, persistently active isoform of atypical protein kinase C-zeta (aPKCzeta), which lacks the N-terminal pseudosubstrate regulatory domain. Using a Pavlovian olfactory learning task in Drosop...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Drier EA,Tello MK,Cowan M,Wu P,Blace N,Sacktor TC,Yin JC

    更新日期:2002-04-01 00:00:00

  • Widespread RNA editing dysregulation in brains from autistic individuals.

    abstract::Transcriptomic analyses of postmortem brains have begun to elucidate molecular abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in synaptic development, RNA editing, has not yet been studied on a genome-wide scale. Here we profiled global patterns of adenosine-to-inosine (A-to-I) ed...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Tran SS,Jun HI,Bahn JH,Azghadi A,Ramaswami G,Van Nostrand EL,Nguyen TB,Hsiao YE,Lee C,Pratt GA,Martínez-Cerdeño V,Hagerman RJ,Yeo GW,Geschwind DH,Xiao X

    更新日期:2019-01-01 00:00:00

  • Function and developmental origin of a mesocortical inhibitory circuit.

    abstract::Midbrain ventral tegmental neurons project to the prefrontal cortex and modulate cognitive functions. Using viral tracing, optogenetics and electrophysiology, we found that mesocortical neurons in the mouse ventrotegmental area provide fast glutamatergic excitation of GABAergic interneurons in the prefrontal cortex an...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Kabanova A,Pabst M,Lorkowski M,Braganza O,Boehlen A,Nikbakht N,Pothmann L,Vaswani AR,Musgrove R,Di Monte DA,Sauvage M,Beck H,Blaess S

    更新日期:2015-06-01 00:00:00

  • Acute changes in short-term plasticity at synapses with elevated levels of neuronal calcium sensor-1.

    abstract::Short-term synaptic plasticity is a defining feature of neuronal activity, but the underlying molecular mechanisms are poorly understood. Depression of synaptic activity might be due to limited vesicle availability, whereas facilitation is thought to result from elevated calcium levels. However, it is unclear whether ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Sippy T,Cruz-Martín A,Jeromin A,Schweizer FE

    更新日期:2003-10-01 00:00:00

  • Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs.

    abstract::Temporal regulation of embryonic neurogenesis is controlled by hypostable transcription factors. The mechanism of the process is unclear. Here we show that the RNase III Drosha and DGCR8 (also known as Pasha), key components of the microRNA (miRNA) microprocessor, have important functions in mouse neurogenesis. Loss o...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Knuckles P,Vogt MA,Lugert S,Milo M,Chong MM,Hautbergue GM,Wilson SA,Littman DR,Taylor V

    更新日期:2012-06-17 00:00:00

  • Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons.

    abstract::Repeated cocaine administration increases the dendritic arborization of nucleus accumbens neurons, but the underlying signaling events remain unknown. Here we show that repeated exposure to cocaine negatively regulates the active form of Rac1, a small GTPase that controls actin remodeling in other systems. Further, we...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Dietz DM,Sun H,Lobo MK,Cahill ME,Chadwick B,Gao V,Koo JW,Mazei-Robison MS,Dias C,Maze I,Damez-Werno D,Dietz KC,Scobie KN,Ferguson D,Christoffel D,Ohnishi Y,Hodes GE,Zheng Y,Neve RL,Hahn KM,Russo SJ,Nestler EJ

    更新日期:2012-06-01 00:00:00

  • Male pheromone-stimulated neurogenesis in the adult female brain: possible role in mating behavior.

    abstract::The regulation of female reproductive behaviors may involve memories of male pheromone signatures, formed in part by neural circuitry involving the olfactory bulb and hippocampus. These neural structures are the principal sites of adult neurogenesis; however, previous studies point to their independent regulation by s...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Mak GK,Enwere EK,Gregg C,Pakarainen T,Poutanen M,Huhtaniemi I,Weiss S

    更新日期:2007-08-01 00:00:00

  • Circuit dissection of the role of somatostatin in itch and pain.

    abstract::Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Huang J,Polgár E,Solinski HJ,Mishra SK,Tseng PY,Iwagaki N,Boyle KA,Dickie AC,Kriegbaum MC,Wildner H,Zeilhofer HU,Watanabe M,Riddell JS,Todd AJ,Hoon MA

    更新日期:2018-05-01 00:00:00

  • Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells.

    abstract::Radial glial progenitor cells exhibit bidirectional cell cycle-dependent nuclear oscillations. The purpose and underlying mechanism of this unusual 'interkinetic nuclear migration' are poorly understood. We investigated the basis for this behavior by live imaging of nuclei, centrosomes and microtubules in embryonic ra...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Tsai JW,Lian WN,Kemal S,Kriegstein AR,Vallee RB

    更新日期:2010-12-01 00:00:00

  • Differential control over cocaine-seeking behavior by nucleus accumbens core and shell.

    abstract::Nucleus accumbens (NAc) dopamine is widely implicated in mediating the reinforcing effects of drugs of abuse. However, the precise function of the NAc itself in drug self-administration has been difficult to establish. Here we show a neural double-dissociation of the behavioral processes that underlie cocaine self-adm...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Ito R,Robbins TW,Everitt BJ

    更新日期:2004-04-01 00:00:00

  • NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity.

    abstract::Recent evidence suggests that presynaptic-acting NMDA receptors (preNMDARs) are important for neocortical synaptic transmission and plasticity. We found that unique properties of the NR3A subunit enable preNMDARs to enhance spontaneous and evoked glutamate release and that NR3A is required for spike timing-dependent l...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Larsen RS,Corlew RJ,Henson MA,Roberts AC,Mishina M,Watanabe M,Lipton SA,Nakanishi N,Pérez-Otaño I,Weinberg RJ,Philpot BD

    更新日期:2011-03-01 00:00:00

  • CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking.

    abstract::Increases in dopamine and glutamate transmission in the nucleus accumbens independently promote the reinstatement of cocaine seeking, an animal model of relapse. Here we have tested whether cocaine reinstatement in rats depends on interactions between accumbal dopamine and glutamate systems that are mediated by Ca(2+)...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Anderson SM,Famous KR,Sadri-Vakili G,Kumaresan V,Schmidt HD,Bass CE,Terwilliger EF,Cha JH,Pierce RC

    更新日期:2008-03-01 00:00:00

  • Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow.

    abstract::Blood flow into the brain is dynamically regulated to satisfy the changing metabolic requirements of neurons, but how this is accomplished has remained unclear. Here we demonstrate a central role for capillary endothelial cells in sensing neural activity and communicating it to upstream arterioles in the form of an el...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Longden TA,Dabertrand F,Koide M,Gonzales AL,Tykocki NR,Brayden JE,Hill-Eubanks D,Nelson MT

    更新日期:2017-05-01 00:00:00

  • Experience-dependent recovery of vision following chronic deprivation amblyopia.

    abstract::The shift in ocular dominance induced by brief monocular deprivation is greatest during a postnatal critical period and is thought to decline irreversibly thereafter. However, here we demonstrate that complete visual deprivation through dark exposure restores rapid ocular dominance plasticity in adult rats. In additio...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: He HY,Ray B,Dennis K,Quinlan EM

    更新日期:2007-09-01 00:00:00

  • NMDA receptor-independent long-term depression correlates with successful aging in rats.

    abstract::Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plastici...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Lee HK,Min SS,Gallagher M,Kirkwood A

    更新日期:2005-12-01 00:00:00

  • Regulation of T-type calcium channels by Rho-associated kinase.

    abstract::We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, wher...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Iftinca M,Hamid J,Chen L,Varela D,Tadayonnejad R,Altier C,Turner RW,Zamponi GW

    更新日期:2007-07-01 00:00:00

  • Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

    abstract::Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein causes neurodegeneration remain unknown. Here we show that lymphoblast mitochondria from patients with HD have a lower membrane potential and ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Panov AV,Gutekunst CA,Leavitt BR,Hayden MR,Burke JR,Strittmatter WJ,Greenamyre JT

    更新日期:2002-08-01 00:00:00

  • Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys.

    abstract::Many attempts to obtain reliable self-administration behavior by laboratory animals with delta-9-tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, have been unsuccessful. Because self-administration behavior has been demonstrated in laboratory animals for almost all other psychoactive drugs abused ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Tanda G,Munzar P,Goldberg SR

    更新日期:2000-11-01 00:00:00

  • Direction selectivity is computed by active dendritic integration in retinal ganglion cells.

    abstract::Active dendritic integration is thought to enrich the computational power of central neurons. However, a direct role of active dendritic processing in the execution of defined neuronal computations in intact neural networks has not been established. Here we used multi-site electrophysiological recording techniques to ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Sivyer B,Williams SR

    更新日期:2013-12-01 00:00:00

  • A small number of open Ca2+ channels trigger transmitter release at a central GABAergic synapse.

    abstract::To determine the number of open Ca(2+) channels necessary for transmitter release at the inhibitory basket cell-granule cell synapse in rat hippocampus, we combined presynaptic Ca(2+) imaging, recording of postsynaptic currents and modeling. We found that that the opening of three or fewer Ca(2+) channels triggered tr...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Bucurenciu I,Bischofberger J,Jonas P

    更新日期:2010-01-01 00:00:00

  • Attentional modulation of human auditory cortex.

    abstract::Attention powerfully influences auditory perception, but little is understood about the mechanisms whereby attention sharpens responses to unattended sounds. We used high-resolution surface mapping techniques (using functional magnetic resonance imaging, fMRI) to examine activity in human auditory cortex during an int...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Petkov CI,Kang X,Alho K,Bertrand O,Yund EW,Woods DL

    更新日期:2004-06-01 00:00:00

  • Multimodal population brain imaging in the UK Biobank prospective epidemiological study.

    abstract::Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Miller KL,Alfaro-Almagro F,Bangerter NK,Thomas DL,Yacoub E,Xu J,Bartsch AJ,Jbabdi S,Sotiropoulos SN,Andersson JL,Griffanti L,Douaud G,Okell TW,Weale P,Dragonu I,Garratt S,Hudson S,Collins R,Jenkinson M,Matthews PM,

    更新日期:2016-11-01 00:00:00

  • The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations.

    abstract::During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Nery S,Fishell G,Corbin JG

    更新日期:2002-12-01 00:00:00

  • A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing.

    abstract::Cell type-specific expression of optogenetic molecules allows temporally precise manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2-tdTomato and ChR2-EYFP, halorhodopsin eNpHR3.0 and archaerhodopsi...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Madisen L,Mao T,Koch H,Zhuo JM,Berenyi A,Fujisawa S,Hsu YW,Garcia AJ 3rd,Gu X,Zanella S,Kidney J,Gu H,Mao Y,Hooks BM,Boyden ES,Buzsáki G,Ramirez JM,Jones AR,Svoboda K,Han X,Turner EE,Zeng H

    更新日期:2012-03-25 00:00:00

  • Laminar differences in the orientation selectivity of geniculate afferents in mouse primary visual cortex.

    abstract::It has been debated whether orientation selectivity in mouse primary visual cortex (V1) is derived from tuned lateral geniculate nucleus (LGN) inputs or computed from untuned LGN inputs. However, few studies have measured orientation tuning of LGN axons projecting to V1. We measured the response properties of mouse LG...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Kondo S,Ohki K

    更新日期:2016-02-01 00:00:00

  • Why pictures look right when viewed from the wrong place.

    abstract::A picture viewed from its center of projection generates the same retinal image as the original scene, so the viewer perceives the scene correctly. When a picture is viewed from other locations, the retinal image specifies a different scene, but we normally do not notice the changes. We investigated the mechanism unde...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Vishwanath D,Girshick AR,Banks MS

    更新日期:2005-10-01 00:00:00

  • Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation.

    abstract::Chondroitinase ABC treatment promotes spinal cord plasticity. We investigated whether chondroitinase-induced plasticity combined with physical rehabilitation promotes recovery of manual dexterity in rats with cervical spinal cord injuries. Rats received a C4 dorsal funiculus cut followed by chondroitinase ABC or penic...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: García-Alías G,Barkhuysen S,Buckle M,Fawcett JW

    更新日期:2009-09-01 00:00:00

  • Transmitter release at the hair cell ribbon synapse.

    abstract::Neurotransmitters are released continuously at ribbon synapses in the retina and cochlea. Notably, a single ribbon synapse of inner hair cells provides the entire input to each cochlear afferent fiber. We investigated hair cell transmitter release in the postnatal rat cochlea by recording excitatory postsynaptic curre...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Glowatzki E,Fuchs PA

    更新日期:2002-02-01 00:00:00

  • Species-specific calls activate homologs of Broca's and Wernicke's areas in the macaque.

    abstract::The origin of brain mechanisms that support human language-whether these originated de novo in humans or evolved from a neural substrate that existed in a common ancestor-remains a controversial issue. Although the answer is not provided by the fossil record, it is possible to make inferences by studying living specie...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Gil-da-Costa R,Martin A,Lopes MA,Muñoz M,Fritz JB,Braun AR

    更新日期:2006-08-01 00:00:00

  • Bidirectional plasticity of cortical pattern recognition and behavioral sensory acuity.

    abstract::Learning to adapt to a complex and fluctuating environment requires the ability to adjust neural representations of sensory stimuli. Through pattern completion processes, cortical networks can reconstruct familiar patterns from degraded input patterns, whereas pattern separation processes allow discrimination of even ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章


    authors: Chapuis J,Wilson DA

    更新日期:2011-11-20 00:00:00