Continuous shifts in the active set of spinal interneurons during changes in locomotor speed.

abstract：:Attention powerfully influences auditory perception, but little is understood about the mechanisms whereby attention sharpens responses to unattended sounds. We used high-resolution surface mapping techniques (using functional magnetic resonance imaging, fMRI) to examine activity in human auditory cortex during an int...

journal_title：Nature neuroscience

authors： Petkov CI,Kang X,Alho K,Bertrand O,Yund EW,Woods DL

更新日期：2004-06-01 00:00:00

abstract：:We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain endothelial cells. These animals showed no fever and no central prostaglandin (PG) E2 synthesis after peripheral injection of bacterial-wall lipopo...

journal_title：Nature neuroscience

authors： Engblom D,Saha S,Engström L,Westman M,Audoly LP,Jakobsson PJ,Blomqvist A

更新日期：2003-11-01 00:00:00

abstract：:As the neural network becomes wired, postsynaptic signaling molecules are thought to control the growth of dendrites and synapses. However, how these molecules are coordinated to sculpt postsynaptic structures is less well understood. We find that ephrin-B3, a transmembrane ligand for Eph receptors, functions postsyna...

journal_title：Nature neuroscience

authors： Xu NJ,Sun S,Gibson JR,Henkemeyer M

更新日期：2011-10-02 00:00:00

abstract：:Intrinsic signal imaging from inferotemporal (IT) cortex, a visual area essential for object perception and recognition, revealed that visually presented objects activated patches in a distributed manner. When visual features of these objects were partially removed, the simplified stimuli activated only a subset of th...

journal_title：Nature neuroscience

authors： Tsunoda K,Yamane Y,Nishizaki M,Tanifuji M

更新日期：2001-08-01 00:00:00

abstract：:T cells clear virus from the CNS and dynamically regulate brain functions, including spatial learning, through cytokine signaling. Here we determined whether hippocampal T cells that persist after recovery from infection with West Nile virus (WNV) or Zika virus (ZIKV) impact hippocampal-dependent learning and memory. ...

journal_title：Nature neuroscience

authors： Garber C,Soung A,Vollmer LL,Kanmogne M,Last A,Brown J,Klein RS

更新日期：2019-08-01 00:00:00

abstract：:The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant wo...

journal_title：Nature neuroscience

authors： Liu J,Ward A,Gao J,Dong Y,Nishio N,Inada H,Kang L,Yu Y,Ma D,Xu T,Mori I,Xie Z,Xu XZ

更新日期：2010-06-01 00:00:00

abstract：:Lis1 gene defects impair neuronal migration, causing the severe human brain malformation lissencephaly. Although much is known about its interactions with microtubules, microtubule-binding proteins such as CLIP-170, and with the dynein motor complex, the response of Lis1 to neuronal motility signals has not been eluci...

journal_title：Nature neuroscience

authors： Kholmanskikh SS,Koeller HB,Wynshaw-Boris A,Gomez T,Letourneau PC,Ross ME

更新日期：2006-01-01 00:00:00

abstract：:Dopamine is vital for coordinated motion and for association learning linked to behavioral reinforcement. Here we show that the precise overlap of striatal dopaminergic and cholinergic fibers underlies potent control of dopamine release by ongoing nicotinic receptor activity. In mouse striatal slices, nicotinic antago...

journal_title：Nature neuroscience

authors： Zhou FM,Liang Y,Dani JA

更新日期：2001-12-01 00:00:00

abstract：:Previous work has shown that human adolescents may be hypersensitive to rewards, but it is not known which aspect of reward processing is responsible for this. We separated decision value and prediction error signals and found that neural prediction error signals in the striatum peaked in adolescence, whereas neural d...

journal_title：Nature neuroscience

authors： Cohen JR,Asarnow RF,Sabb FW,Bilder RM,Bookheimer SY,Knowlton BJ,Poldrack RA

更新日期：2010-06-01 00:00:00

abstract：:Although de novo missense mutations have been predicted to account for more cases of autism than gene-truncating mutations, most research has focused on the latter. We identified the properties of de novo missense mutations in patients with neurodevelopmental disorders (NDDs) and highlight 35 genes with excess missens...

journal_title：Nature neuroscience

authors： Geisheker MR,Heymann G,Wang T,Coe BP,Turner TN,Stessman HAF,Hoekzema K,Kvarnung M,Shaw M,Friend K,Liebelt J,Barnett C,Thompson EM,Haan E,Guo H,Anderlid BM,Nordgren A,Lindstrand A,Vandeweyer G,Alberti A,Avola E,V

更新日期：2017-08-01 00:00:00

abstract：:Glycine receptors (GlyRs), together with GABA(A) and nicotinic acetylcholine (ACh) receptors, form part of the ligand-activated ion channel superfamily and regulate the excitability of the mammalian brain stem and spinal cord. Here we report that the ability of the neurotransmitter glycine to gate recombinant and nati...

journal_title：Nature neuroscience

authors： Yevenes GE,Peoples RW,Tapia JC,Parodi J,Soto X,Olate J,Aguayo LG

更新日期：2003-08-01 00:00:00

abstract：:Successfully navigating in physical or semantic space requires a neural representation of allocentric (map-based) vectors to boundaries, objects and goals. Cognitive processes such as path-planning and imagination entail the recall of vector representations, but evidence of neuron-level memory for allocentric vectors ...

journal_title：Nature neuroscience

authors： Poulter S,Lee SA,Dachtler J,Wills TJ,Lever C

更新日期：2020-12-21 00:00:00

abstract：:Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans res...

journal_title：Nature neuroscience

authors： Stoodley CJ,D'Mello AM,Ellegood J,Jakkamsetti V,Liu P,Nebel MB,Gibson JM,Kelly E,Meng F,Cano CA,Pascual JM,Mostofsky SH,Lerch JP,Tsai PT

更新日期：2017-12-01 00:00:00

abstract：:Polyamines are endogenous molecules involved in cell damage following neurological insults, although it is unclear whether polyamines reduce or exacerbate this damage. We used a developmental seizure model in which we exposed Xenopus laevis tadpoles to pentylenetetrazole (PTZ), a known convulsant. We found that, after...

journal_title：Nature neuroscience

authors： Bell MR,Belarde JA,Johnson HF,Aizenman CD

更新日期：2011-04-01 00:00:00

abstract：:The most critical attribute of human language is its unbounded combinatorial nature: smaller elements can be combined into larger structures on the basis of a grammatical system, resulting in a hierarchy of linguistic units, such as words, phrases and sentences. Mentally parsing and representing such structures, howev...

journal_title：Nature neuroscience

authors： Ding N,Melloni L,Zhang H,Tian X,Poeppel D

更新日期：2016-01-01 00:00:00

abstract：:In mammals, many daily cycles are driven by a central circadian clock, which is based on the cell-autonomous rhythmic expression of clock genes. It is not clear, however, how peripheral cells are able to interpret the rhythmic signals disseminated from this central oscillator. Here we show that cycling expression of t...

journal_title：Nature neuroscience

authors： von Gall C,Garabette ML,Kell CA,Frenzel S,Dehghani F,Schumm-Draeger PM,Weaver DR,Korf HW,Hastings MH,Stehle JH

更新日期：2002-03-01 00:00:00

abstract：:Deciphering the interneuronal circuitry is central to understanding brain functions, yet it remains a challenging task in neurobiology. Using simultaneous quadruple-octuple in vitro and dual in vivo whole-cell recordings, we found two previously unknown interneuronal circuits that link cortical layer 1-3 (L1-3) intern...

journal_title：Nature neuroscience

authors： Jiang X,Wang G,Lee AJ,Stornetta RL,Zhu JJ

更新日期：2013-02-01 00:00:00

abstract：:Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation has been implicated in a wide range of diseases. Here we demonstrate that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like recepto...

journal_title：Nature neuroscience

authors： Hess ME,Hess S,Meyer KD,Verhagen LA,Koch L,Brönneke HS,Dietrich MO,Jordan SD,Saletore Y,Elemento O,Belgardt BF,Franz T,Horvath TL,Rüther U,Jaffrey SR,Kloppenburg P,Brüning JC

更新日期：2013-08-01 00:00:00

abstract：:Striatal parvalbumin (PV) and cholinergic interneurons (CHIs) are poised to play major roles in behavior by coordinating the networks of medium spiny cells that relay motor output. However, the small numbers and scattered distribution of these cells have hindered direct assessment of their contribution to activity in ...

journal_title：Nature neuroscience

authors： Gritton HJ,Howe WM,Romano MF,DiFeliceantonio AG,Kramer MA,Saligrama V,Bucklin ME,Zemel D,Han X

更新日期：2019-04-01 00:00:00

abstract：:We used ultrasound image-guided injections of high-titer retroviral vectors to obtain widespread introduction of genes into the mouse nervous system in utero as early as embryonic day 8.5 (E8.5). The vectors used included internal promoters that substantially improved proviral gene expression in the ventricular zone o...

journal_title：Nature neuroscience

authors： Gaiano N,Kohtz JD,Turnbull DH,Fishell G

更新日期：1999-09-01 00:00:00

abstract：:Precise apposition of pre- to postsynaptic specializations is required for optimal function of chemical synapses, but little is known about how it is achieved. At the skeletal neuromuscular junction, active zones (transmitter release sites) in the nerve terminal lie directly opposite junctional folds in the postsynapt...

journal_title：Nature neuroscience

authors： Patton BL,Cunningham JM,Thyboll J,Kortesmaa J,Westerblad H,Edström L,Tryggvason K,Sanes JR

更新日期：2001-06-01 00:00:00

abstract：:An afterimage looks larger when one fixates on a distant than on a closer surface. We show that the retinotopic activity in the primary visual cortex (V1) associated with viewing an afterimage is modulated by perceived size, even when the size of the retinal image remains constant. This suggests that V1 has an importa...

journal_title：Nature neuroscience

authors： Sperandio I,Chouinard PA,Goodale MA

更新日期：2012-03-11 00:00:00

abstract：:Amyloid plaques are a hallmark of Alzheimer disease, but their importance in its pathogenesis is controversial. By neuronal labeling and transcranial two-photon imaging, we show in a transgenic mouse model of Alzheimer disease that dendrites passing through or near fibrillar amyloid deposits undergo spine loss and sha...

journal_title：Nature neuroscience

authors： Tsai J,Grutzendler J,Duff K,Gan WB

更新日期：2004-11-01 00:00:00

abstract：:Sensory neural systems use spatiotemporal coding mechanisms to represent stimuli. These time-varying response patterns sometimes outlast the stimulus. Can the temporal structure of a stimulus interfere with, or even disrupt, the spatiotemporal structure of the neural representation? We investigated this potential conf...

journal_title：Nature neuroscience

authors： Brown SL,Joseph J,Stopfer M

更新日期：2005-11-01 00:00:00

abstract：:The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A...

journal_title：Nature neuroscience

authors： He W,Lam TK,Obici S,Rossetti L

更新日期：2006-02-01 00:00:00

abstract：:Replay of hippocampal place cell sequences has been proposed as a fundamental mechanism of learning and memory. However, the standard interpretation of replay has been challenged by reports that similar activity is observed before experience ('preplay'). By the preplay account, pre-existing temporal sequences are mapp...

journal_title：Nature neuroscience

authors： Silva D,Feng T,Foster DJ

更新日期：2015-12-01 00:00:00

abstract：:From insects to mammals, olfactory receptor neurons (ORNs) expressing a common olfactory receptor target their axons to specific glomeruli with high precision. Here we show in Drosophila that the POU transcription factor Acj6 controls the axon targeting specificity of a subset of ORN classes, as defined by the olfacto...

journal_title：Nature neuroscience

authors： Komiyama T,Carlson JR,Luo L

更新日期：2004-08-01 00:00:00

abstract：:Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that...

journal_title：Nature neuroscience

authors： Lamprecht R,Farb CR,Rodrigues SM,LeDoux JE

更新日期：2006-04-01 00:00:00

abstract：:Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and h...

journal_title：Nature neuroscience

authors： Mato S,Chevaleyre V,Robbe D,Pazos A,Castillo PE,Manzoni OJ

更新日期：2004-06-01 00:00:00

abstract：:At glutamatergic synapses, calcium influx through NMDA receptors (NMDARs) is required for long-term potentiation (LTP); this is a proposed cellular mechanism underlying memory and learning. Here we show that in lateral amygdala pyramidal neurons, SK channels are also activated by calcium influx through synaptically ac...

journal_title：Nature neuroscience

authors： Faber ES,Delaney AJ,Sah P

更新日期：2005-05-01 00:00:00