Properly formed but improperly localized synaptic specializations in the absence of laminin alpha4.

abstract：:The amygdala is essential for fear learning and expression. The central amygdala (CeA), once viewed as a passive relay between the amygdala complex and downstream fear effectors, has emerged as an active participant in fear conditioning. However, the mechanism by which CeA contributes to the learning and expression of...

journal_title：Nature neuroscience

authors： Li H,Penzo MA,Taniguchi H,Kopec CD,Huang ZJ,Li B

更新日期：2013-03-01 00:00:00

abstract：:When sleep followed implicit training on a motor sequence, children showed greater gains in explicit sequence knowledge after sleep than adults. This greater explicit knowledge in children was linked to their higher sleep slow-wave activity and to stronger hippocampal activation at explicit knowledge retrieval. Our da...

journal_title：Nature neuroscience

authors： Wilhelm I,Rose M,Imhof KI,Rasch B,Büchel C,Born J

更新日期：2013-04-01 00:00:00

abstract：:The production of hippocampal granule neurons continues throughout adulthood but dramatically decreases in old age. Here we show that reducing corticosteroid levels in aged rats restored the rate of cell proliferation, resulting in increased numbers of new granule neurons. This result indicates that the neuronal precu...

journal_title：Nature neuroscience

authors： Cameron HA,McKay RD

更新日期：1999-10-01 00:00:00

abstract：:The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR...

journal_title：Nature neuroscience

authors： Costa-Mattioli M,Monteggia LM

更新日期：2013-11-01 00:00:00

abstract：:Neuroscientists increasingly analyze the joint activity of multineuron recordings to identify population-level structures believed to be significant and scientifically novel. Claims of significant population structure support hypotheses in many brain areas. However, these claims require first investigating the possibi...

journal_title：Nature neuroscience

authors： Elsayed GF,Cunningham JP

更新日期：2017-09-01 00:00:00

abstract：:It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to m...

journal_title：Nature neuroscience

authors： Kupchik YM,Brown RM,Heinsbroek JA,Lobo MK,Schwartz DJ,Kalivas PW

更新日期：2015-09-01 00:00:00

abstract：:Humans and other primates sample the visual environment using saccadic eye movements that shift a high-resolution fovea toward regions of interest to create a clear perception of a scene across fixations. Many mammals, however, like mice, lack a fovea, which raises the question of why they make saccades. Here we descr...

journal_title：Nature neuroscience

authors： Samonds JM,Geisler WS,Priebe NJ

更新日期：2018-11-01 00:00:00

abstract：:Axonal injury results in regenerative success or failure, depending on whether the axon lies in the peripheral or the CNS, respectively. The present study addresses whether epigenetic signatures in dorsal root ganglia discriminate between regenerative and non-regenerative axonal injury. Chromatin immunoprecipitation f...

journal_title：Nature neuroscience

authors： Palmisano I,Danzi MC,Hutson TH,Zhou L,McLachlan E,Serger E,Shkura K,Srivastava PK,Hervera A,Neill NO,Liu T,Dhrif H,Wang Z,Kubat M,Wuchty S,Merkenschlager M,Levi L,Elliott E,Bixby JL,Lemmon VP,Di Giovanni S

更新日期：2019-11-01 00:00:00

abstract：:The basis for differences in activity-dependent trafficking of AMPA receptors (AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C a...

journal_title：Nature neuroscience

authors： Groc L,Heine M,Cognet L,Brickley K,Stephenson FA,Lounis B,Choquet D

更新日期：2004-07-01 00:00:00

abstract：:Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and ...

journal_title：Nature neuroscience

authors： Land BB,Narayanan NS,Liu RJ,Gianessi CA,Brayton CE,Grimaldi DM,Sarhan M,Guarnieri DJ,Deisseroth K,Aghajanian GK,DiLeone RJ

更新日期：2014-02-01 00:00:00

abstract：:Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial re...

journal_title：Nature neuroscience

authors： Murray AJ,Sauer JF,Riedel G,McClure C,Ansel L,Cheyne L,Bartos M,Wisden W,Wulff P

更新日期：2011-03-01 00:00:00

abstract：:Entorhinal grid cells in mammals fire as a function of animal location, with spatially periodic response patterns. This nonlocal periodic representation of location, a local variable, is unlike other neural codes. There is no theoretical explanation for why such a code should exist. We examined how accurately the grid...

journal_title：Nature neuroscience

authors： Sreenivasan S,Fiete I

更新日期：2011-09-11 00:00:00

abstract：:We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wild-type mice. DSBs occurred in multiple brain regions, were most abundant in the dentate gyrus, which is involved in learning and memory, and were repaired within 24 h. Increasing neu...

journal_title：Nature neuroscience

authors： Suberbielle E,Sanchez PE,Kravitz AV,Wang X,Ho K,Eilertson K,Devidze N,Kreitzer AC,Mucke L

更新日期：2013-05-01 00:00:00

abstract：:Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein) function, gene regulation and neuron survival. Calcium entry through synaptic NMDA receptors induced CREB activity and brain-derived neurotrophic factor (BDNF) gene...

journal_title：Nature neuroscience

authors： Hardingham GE,Fukunaga Y,Bading H

更新日期：2002-05-01 00:00:00

abstract：:Axon guidance cues contributing to the development of eye-specific visual projections to the lateral geniculate nucleus (LGN) have not previously been identified. Here we show that gradients of ephrin-As and their receptors (EphAs) direct retinal ganglion cell (RGC) axons from the two eyes into their stereotyped patte...

journal_title：Nature neuroscience

authors： Huberman AD,Murray KD,Warland DK,Feldheim DA,Chapman B

更新日期：2005-08-01 00:00:00

abstract：:The retina of warm-blooded vertebrates is believed to be incapable of neural regeneration. Here we provide evidence that the retina of postnatal chickens has the potential to generate new neurons. In response to acute damage, numerous Müller glia re-entered the cell cycle, and shortly thereafter, expressed CASH-1, Pax...

journal_title：Nature neuroscience

authors： Fischer AJ,Reh TA

更新日期：2001-03-01 00:00:00

abstract：:A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural conne...

journal_title：Nature neuroscience

authors： Saygin ZM,Osher DE,Koldewyn K,Reynolds G,Gabrieli JD,Saxe RR

更新日期：2011-12-25 00:00:00

abstract：:Dopamine signaling is implicated in reinforcement learning, but the neural substrates targeted by dopamine are poorly understood. We bypassed dopamine signaling itself and tested how optogenetic activation of dopamine D1 or D2 receptor–expressing striatal projection neurons influenced reinforcement learning in mice. S...

journal_title：Nature neuroscience

authors： Kravitz AV,Tye LD,Kreitzer AC

更新日期：2012-06-01 00:00:00

abstract：:We elucidated the intrinsic circuitry of the medial prefrontal cortex and its role in regulating fear extinction, using neuronal tracing and optogenetic stimulation in vitro and in vivo. We show that pyramidal neurons in layer 5/6 of the prelimbic medial prefrontal cortex project to pyramidal cells in layer 5/6 of the...

journal_title：Nature neuroscience

authors： Marek R,Xu L,Sullivan RKP,Sah P

更新日期：2018-05-01 00:00:00

abstract：:Brain circuitry processes information by rapidly and selectively engaging functional neuronal networks. The dynamic formation of networks is often evident in rhythmically synchronized neuronal activity and tightly correlates with perceptual, cognitive and motor performances. But how synchronized neuronal activity cont...

journal_title：Nature neuroscience

authors： Womelsdorf T,Valiante TA,Sahin NT,Miller KJ,Tiesinga P

更新日期：2014-08-01 00:00:00

abstract：:The excitability of individual dendritic branches is a plastic property of neurons. We found that experience in an enriched environment increased propagation of dendritic Na(+) spikes in a subset of individual dendritic branches in rat hippocampal CA1 pyramidal neurons and that this effect was mainly mediated by local...

journal_title：Nature neuroscience

authors： Makara JK,Losonczy A,Wen Q,Magee JC

更新日期：2009-12-01 00:00:00

abstract：:Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT. Our models suggest ...

journal_title：Nature neuroscience

authors： Beuming T,Kniazeff J,Bergmann ML,Shi L,Gracia L,Raniszewska K,Newman AH,Javitch JA,Weinstein H,Gether U,Loland CJ

更新日期：2008-07-01 00:00:00

abstract：:Animals strategically scan the environment to form an accurate perception of their surroundings. Here we investigated the neuronal representations that mediate this behavior. Ca2+ imaging and selective optogenetic manipulation during an active sensing task reveals that layer 5 pyramidal neurons in the vibrissae cortex...

journal_title：Nature neuroscience

authors： Ranganathan GN,Apostolides PF,Harnett MT,Xu NL,Druckmann S,Magee JC

更新日期：2018-11-01 00:00:00

abstract：:We used high-level configural aftereffects induced by adaptation to realistic faces to investigate visual representations underlying complex pattern perception. We found that exposure to an individual face for a few seconds generated a significant and precise bias in the subsequent perception of face identity. In the ...

journal_title：Nature neuroscience

authors： Leopold DA,O'Toole AJ,Vetter T,Blanz V

更新日期：2001-01-01 00:00:00

abstract：:Exposures to cocaine and morphine produce similar adaptations in nucleus accumbens (NAc)-based behaviors, yet produce very different adaptations at NAc excitatory synapses. In an effort to explain this paradox, we found that both drugs induced NMDA receptor-containing, AMPA receptor-silent excitatory synapses, albeit ...

journal_title：Nature neuroscience

authors： Graziane NM,Sun S,Wright WJ,Jang D,Liu Z,Huang YH,Nestler EJ,Wang YT,Schlüter OM,Dong Y

更新日期：2016-07-01 00:00:00

abstract：:At glutamatergic synapses, calcium influx through NMDA receptors (NMDARs) is required for long-term potentiation (LTP); this is a proposed cellular mechanism underlying memory and learning. Here we show that in lateral amygdala pyramidal neurons, SK channels are also activated by calcium influx through synaptically ac...

journal_title：Nature neuroscience

authors： Faber ES,Delaney AJ,Sah P

更新日期：2005-05-01 00:00:00

abstract：:Nucleus HVc of the avian song system is a forebrain structure critical in song production, perception and learning. Here we show that most HVc neurons that respond to auditory stimuli under anesthesia show no responses to the same stimulus in the awake, unrestrained bird. This suppression of auditory responses in awak...

journal_title：Nature neuroscience

authors： Schmidt MF,Konishi M

更新日期：1998-10-01 00:00:00

abstract：:Trial-to-trial variability in the blood oxygen level-dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity accou...

journal_title：Nature neuroscience

authors： Fox MD,Snyder AZ,Zacks JM,Raichle ME

更新日期：2006-01-01 00:00:00

abstract：:Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most resisting the development of neuropsychiatric disorders. Over the past 5 years, there has been increasing interest in the active, adaptive coping mechanisms of resilience; however, in humans, most published work focuses on correl...

journal_title：Nature neuroscience

authors： Russo SJ,Murrough JW,Han MH,Charney DS,Nestler EJ

更新日期：2012-11-01 00:00:00

abstract：:Rhythmic movements, such as walking, chewing or scratching, are phylogenetically old motor behaviors found in many organisms, ranging from insects to primates. In contrast, discrete movements, such as reaching, grasping or kicking, are behaviors that have reached sophistication primarily in younger species, particular...

journal_title：Nature neuroscience

authors： Schaal S,Sternad D,Osu R,Kawato M

更新日期：2004-10-01 00:00:00