Abstract：
:Animals strategically scan the environment to form an accurate perception of their surroundings. Here we investigated the neuronal representations that mediate this behavior. Ca2+ imaging and selective optogenetic manipulation during an active sensing task reveals that layer 5 pyramidal neurons in the vibrissae cortex produce a diverse and distributed representation that is required for mice to adapt their whisking motor strategy to changing sensory cues. The optogenetic perturbation degraded single-neuron selectivity and network population encoding through a selective inhibition of active dendritic integration. Together the data indicate that active dendritic integration in pyramidal neurons produces a nonlinearly mixed network representation of joint sensorimotor parameters that is used to transform sensory information into motor commands during adaptive behavior. The prevalence of the layer 5 cortical circuit motif suggests that this is a general circuit computation.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Ranganathan GN,Apostolides PF,Harnett MT,Xu NL,Druckmann S,Magee JCdoi
10.1038/s41593-018-0254-6subject
Has Abstractpub_date
2018-11-01 00:00:00pages
1583-1590issue
11eissn
1097-6256issn
1546-1726pii
10.1038/s41593-018-0254-6journal_volume
21pub_type
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